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Jan 08, 2025Open    Access

Advancement in Nanoparticle-Based NIRF Probes for Precision Visualization in Oncology

Michael Adeniyi
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1112471


Sep 04, 2024Open    Access

The Regulation of Slow-Wave Sleep on Growth Hormone Secretion and Homeostatic Aging: A Pure Model in Man

Zi-Jian Cai
Introduction: It is complicated for regulation of growth hormone (GH) secretion. Herein, it is considered the effects of slow-wave sleep (SWS) on GH secretion and related homeostatic aging, and their implications to other complicated GH secretions. Methods: It was best and most convincing to integratively review the literatures in various fields, especially the relationship among GH, SWS, aging, evolution, etc., and then discuss and summarize to deal with such a...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112041


Oct 30, 2023Open    Access

Exploring the Recognition of Dogs as Sentient Beings: Understanding the Evolution of Dog Psychology

Jessica Torrance
Dogs have a profound history of companionship with humans, evolving from utilitarian tools to cherished sentient beings deserving empathy and consideration. This study explores the transformation of society's perception of dogs from historical, scientific, and philosophical viewpoints. Objectives: This study sought to achieve three main objectives: 1) explore historical and cultural perspectives on dog sentience, 2) analyse scientific evidence supporting the concept of dog sentience, and 3) inve...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110780


Jun 17, 2022Open    Access

Somite and Brain Nociceptive Coupling in Evolution of Nociceptive-Sympathetic Coupling for Pain Sensations by NBA

Zi-Jian Cai
In May 2016, it was proposed by the US athletes of the National Basketball Association (NBA) on television that the nociceptive-sympathetic coupling be required for pain sensations. Later, it was demonstrated that, via the activation of sympathetic outputs directly by the nociceptive neurons in laminae I and V of the dorsal spinal horn as well as those in periaqueductal grey (PAG) of brain, it was completed the nociceptive-sympathetic coupling in vertebrates. In this article, for the evolutionar...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108867


Aug 25, 2021Open    Access

Uncharted Territory—Rehabilitation Potential in a Prolonged COVID-19 ICU Stay Complicated by PRES

Samuel Moody, Vinay Parambil, Fayez Morcos
The long-term complications of COVID-19 and its management, and rehabilitation potential post-recovery remain poorly understood. Here we describe the case of posterior reversible encephalopathy syndrome and subsequent neuro-rehabilitation outcome of a patient following an extended ICU stay with COVID-19 infection (and complications). Rehabilitation potential and mirroring research are discussed.
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107627


Jul 01, 2021Open    Access

The Dopaminergic and Acetylcholinergic Supplements to Freudian Structural Theory of Psychoanalysis

Zi-Jian Cai
For the Freudian topographic theory of psychoanalysis, it has recently been supplemented the reticular noradrenergic (NA), serotonergic (5-HT) and acetylcholinergic (ACh) systems to demonstrate the differential regulation of unconscious/preconscious/conscious in waking and sleep, applicable to depression and anxiety. For the Freudian structural theory of id/ego/super-ego, it is keen to depict the personal social psychology with selfishness, applicable to schizophrenia. Herein, it is analogously ...
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107603


May 11, 2021Open    Access

Another Train Paradox: May the Myelin Be with You!

Bernard Delalande, Hirohisa Tamagawa, Vladimir Matveev
For more than 70 years, biologists and biophysicists have been trying to unravel the mystery surrounding the saltatory conduction of so-called myelinated neurons. This conduction is indeed very different and faster than for fibres “without” myelin. Many theories have been developed. Albert Einstein used the metaphor of the train to explain the theory of relativity. It is also possible to use a similar metaphor to better understand this transient functioning of the neuron: the transmission of the...
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107379


Dec 25, 2020Open    Access

From Nernst to Bernstein and Beyond

Bernard Delalande, Hirohisa Tamagawa, Vladimir Matveev
Man has always been interested in animal electricity, which seems to be measured in every living cell. He has been fascinated by trying to elucidate the mechanisms by which this potential is created and maintained. Biology is the science that seeks to explain this mystery. Biology is based on basic sciences such as physics or chemistry. The latter, in turn, make systematic use of mathematics to measure, evaluate and predict certain phenomena and to develop “laws” and models that are as general a...
Open Access Library J.   Vol.7, 2020
Doi:10.4236/oalib.1107047


Aug 14, 2020Open    Access

Achieving Functional Independence of Children with Cerebral Palsy at the Mainstream School: An Overview

Md Mahmudul Hasan, Tamjidul Islam
The functional independence of children with cerebral palsy at the mainstream school involves both academic and non-academic activities within the school environment. In order to perform these activities without anyone’s support, proficiency such as literacy, cognition, language, social and physical skills is required to achieve at the individual level and the surrounding environment should be compatible according to the student with cerebral palsy needs. An inclusive educational setting in the ...
Open Access Library J.   Vol.7, 2020
Doi:10.4236/oalib.1106597


Oct 08, 2019Open    Access

The Neural Pathways for the Hypothetic Nociceptive-Sympathetic Coupling of NBA for Pain Sensation

Zi-Jian Cai
In May 2016, it was suggested by the US athletes playing games of National Basketball Association (NBA) in television that the pain sensation might result from the post-sensory nociceptive-sympathetic coupling. In this re-view, it is attempted to newly delineate the underlying neural pathways for this post-sensory nociceptive-sympathetic coupling. Based on the con-temporary feedback neural circuits of pain transmission in spinal c
...
Open Access Library J.   Vol.6, 2019
Doi:10.4236/oalib.1105780


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