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Jun 23, 2025Open    Access

Pharmacogenomic Approaches to Predicting Susceptibility to Neuroleptic Malignant Syndrome and Severe Anticholinergic Adverse Effects: A Multi-Modal Explainable AI Framework

Rocco de Filippis,Abdullah Al Foysal
Neuroleptic Malignant Syndrome (NMS) and severe anticholinergic adverse drug reactions (ADRs) are rare but life-threatening complications associated with antipsychotic pharmacotherapy. These conditions often arise unpredictably, posing significant challenges in psychiatric clinical practice. Current risk stratification approaches lack the granularity to account for complex interplays between genetic predispositions, pharmacological profiles, and individual patient characteristics. In this study,...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113517


Jun 23, 2025Open    Access

Effects of Language Barriers and Social Integration on Academic Achievement of International Students

JohnPaul Chika Okoli,Gabriel Elochukwu Nweke
This study examines the impact of language proficiency on social integration and academic achievement among non-native speakers in educational settings. Utilizing a sample of 200 participants, the research explores how varying levels of language skills influence students’ grades, sense of belonging, and perceived helpfulness of institutional language support programs. Findings indicate a strong correlation (0.95) between high language proficiency and improved academic performance, with “Very Pro...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113542


Jun 23, 2025Open    Access

The Mystery of the Five Flavors Growth-Transformation in the System of Fu Xing Jue Zang Fu Yong Yao Fa Yao

Tao Yang,Yimin Lin,Canjian Wang
The chart of Tang Ye Jing recorded in Fu Xing Jue Zang Fu Yong Yao Fa Yao holds significant academic value for analyzing the formula compatibility principles in Shang Han Lun. The authors constructed the chart of Tang Ye Jing principle Zang Fu Yong Yao Fa Yao based on Tang Ye Jing to systematically elucidate the intrinsic correlations among physicochemical properties, therapeutic functions, and flavor transformations of medicinal substances, and condu...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113606


Jun 23, 2025Open    Access

Innovative Research and Practice of “Hand Art” Intangible Cultural Heritage Study in Jiangnan Cultural Context
—Taking Wuzhou Tie-Dye as an Example

Lu Zhang,Xiaotong Huang
The integration of intangible cultural heritage (ICH) inheritance and educational research is a crucial direction for cultural protection and quality education in the new era. However, existing courses still suffer from issues such as “touring without learning” and low participation. This paper aims to explore innovative pathways for ICH research courses using Wuzhou tie-dyeing as a case study. It seeks to build a curriculum system that combines educational value with practicality. Through liter...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113615


Jun 20, 2025Open    Access

The Illusion of Gender Equality and Participation of Women in Post-Conflict Somalia (2012-2022)

Antonetta Lovejoy Hamandishe,Samuel Kale Ewusi
This study reveals the gap between constitutional guarantees of gender equality and the systemic exclusion of women in practice in post-conflict Somalia (2012-2022). Employing a critical feminist lens, this study deconstructs the hegemony of hybrid governance systems that weaponize legal ambiguity to sustain patriarchal exclusion. Through an intersectional analysis of clan-based political economies, this study examined how informal power structures subvert formal gender quotas and constitutional...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113344


Jun 20, 2025Open    Access

Type 1 Diabetes and Helicobacter pylori in 10-Years-Old Girl: Clinical Case Report

Merlin Wawa Botuli,Christophe Ntalu,Aldophine Nkuadiolando,Christian Kinsiona,Aimé Mupuala,Esther Ekolo,Justin Mbala
Background: Diabetes is one of the most widespread metabolic diseases worldwide and is responsible for approximately 4 million deaths per year in 2010. The global prevalence among adults was estimated at 4.6% affecting around 285 million people. This number rose to 371 million in 2012 and is projected to reach 552 million by 2030. Among the various factors that may influence the incidence of diabetes, infection with Helicobacter pylori has been increasingly studied for ...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113474


Jun 20, 2025Open    Access

From Passive Recipients to Active Thinkers: Taboo Strategy in ELT

Yuanyuan Zhu
This article investigates the implementation of a thinking skills strategy, Taboo strategy, among first-year non-English majors at a university in China. Through the classroom observation and a student survey, the research exemplifies the stages of implementing Taboo and explores how Taboo influences pedagogy and shifts classroom dynamics from passive towards active interactions. Findings indicate significant improvements in students’ engagement in discussions (reported by 92.1% of participants)...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113568


Jun 19, 2025Open    Access

Research on Coordinated Control Strategy of Fuel Cell Anode Pressure and Flow Based on Deep Reinforcement Learning

Wei Lu
In view of the control problem of hydrogen pressure and flow coupling in the anode subsystem of the Proton Exchange Membrane Fuel Cell (PEMFC) under dynamic load conditions, this paper proposes an intelligent control framework based on the deep deterministic policy gradient (DDPG) algorithm. Firstly, a dynamic model of the fuel cell anode system is established to transform the multivariable coupling control problem into a reinforcement learning state space; secondly, a multi-objective reward fun...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113537


Jun 18, 2025Open    Access

Nasolabial Cyst: A Rare Cause of Nasal Obstruction—A Case Report

Fatima Ezzahra Farouq,Dounia Sardi,Ihssan BenYahya
Nasolabial cysts are rare non-odontogenic, soft-tissue, developmental cysts typically found in the sublabial area and anterior maxillary region. These cysts present as slowly enlarging, asymptomatic, and non-painful swellings, often causing effacement of the nasolabial fold and occasionally nasal obstruction. The diagnosis is primarily clinical, with radiological findings being non-specific. However, computed tomography may provide further details. Surgical removal through a sublabial approach i...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113397


Jun 16, 2025Open    Access

A Rare Case of Ameloblastic Fibroma: Association of Central and Peripheral Clinical Forms

Sofia Haitami,Oumaima Fahim,Wafae Mahfoud,Elyas Sabir,Ihsane Ben Yahya
Background: An ameloblastic fibroma (AF) is a rare benign mixed odontogenic tumor, that commonly occurs during the first and the second decade of life, which is why it’s often called a neoplasm of childhood and adolescence. It is composed of both epithelial and mesenchymal components, without any formation of calcified dental structure, and it can present in two clinical forms: a central (intraosseous) and a peripheral (extraosseous) variant. Aim: The aim of thi...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113520


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