Warfarin remains a widely prescribed oral anticoagulant despite its narrow therapeutic index and its association with life-threatening bleeding events. This systematic review examined the impact of clinical risk factors on international normalized ratio (INR) control in patients receiving Warfarin therapy. Following the PRISMA-P guidelines, we searched four electronic databases (PubMed, SCOPUS, Embase, and Web of Science) using Medical Subject Headings to identify eligible cohort studies publish...

Pharmacology 

Background: Prior studies have established that ACL graft healing is a prolonged process, which often lasts up to two years, with the MRI signal intensity ratio (SIR) serving as a key indicator of graft maturity. However, the factors influencing delayed healing, particularly anatomical variation, remain poorly understood. Purpose: To analyze magnetic resonance imaging changes in graft healing 2 years after anterior cruciate ligament reconstruction and identify independent factors associated with...

Radiology & Medical Imaging 

Objective: To describe the clinical manifestations, anatomopathology and therapeutic management of patients. Methodology: This was a retrospective prospective descriptive and analytical study of ten (10) patients followed from November 2017 to September 2024 in the nephrology department of the Centre Hospitalier South Francilien for GNEC. All patients who underwent renal puncture-biopsy with confirmation of extracapillary glomerulonephritis (ECG) were included. Results: During the course of our ...

Nephrology 

Introduction: Heart failure (HF) is a significant public health issue. The objective of this study was to investigate acute kidney injury in the cardiology department. Material and Methods: We conducted a cohort study in the cardiology department over a period of 6 months, from January 1 to June 30, 2024. We included all patients hospitalized for decompensated heart failure (HF) whose diagnosis of acute kidney injury (AKI) was confirmed by a sudden increase in creatinine associated with a urinar...

Nephrology 

Psychological predicates describe mental states and cognitive capacities, reflecting a subject’s internal experiences, emotional states, and cognitive processes, with their degree semantics exhibiting multi-layered distinctions (high, medium, low). Compared with Mandarin, the degree category of psychological predicates in the Yimeng dialect of Shandong exhibits distinct regional characteristics. Based on field investigations, this study systematically examines the semantic representations of deg...

Linguistics 

Against the backdrop of the digital economy’s rapid evolution, the digital transformation of small and medium-sized enterprises (SMEs)—a pivotal driver of China’s economic growth, employment stability, and GDP contribution—has emerged as an imperative agenda. This study employs a questionnaire-based methodology to examine the current landscape and inherent challenges pertaining to the digital transformation of SMEs in China. The survey instrument encompasses 11 items, addressing domains such as ...

Business Management 

This study investigates the effectiveness of formative assessment in senior high school English writing teaching, with a focus on its impact on students’ writing competence and their attitudinal acceptance. Adopting a quasi-experimental design, the research selected two second-year classes from a provincial high school in Z Province in China as participants. The experimental group underwent a one-month formative assessment intervention in writing instruction, while the control group maintained c...

Pedagogy 

Background: Infectious processes are the leading cause of pediatric consultation, and recurrent or severe infections may indicate primary immunodeficiencies (PIDs), which comprise more than 484 rare diseases affecting the immune response. The nature and severity of infections depend on the component of the immune system affected, with defects in humoral immunity being a frequent cause of severe respiratory infections. Evaluation of blood immunoglobulin (Ig) levels is essential for the identifica...

Microbiology  Infectious Diseases  Biochemistry  Immunology  Pediatrics 

This article aims to address the problems encountered in the teaching of the course “Fundamentals of Cloud and Precipitation Physics and Lightning Science” by improving and optimizing classroom content, teaching methods, experimental methods, and assessment methods. The goal is to enrich teaching content, enhance teaching effectiveness, stimulate students’ interest, and cultivate comprehensive talents for the field of atmospheric science through curriculum reform (especially including knowledge ...

Atmospheric Sciences 

Breast milk is crucial for an infant’s nutrition and immunity, especially in the first six months. When direct breastfeeding is not possible, expressing milk becomes essential, yet many mothers face challenges due to limited awareness. The study aimed to assess awareness and attitude on storage and feeding of expressed breast milk among postnatal mothers attending a tertiary hospital, Pokhara. A descriptive cross-sectional study was conducted among 335 postnatal...

Gastroenterology & Hepatology  Women’s Health