High-Dose-Rate (HDR) brachytherapy with an Iridium (Ir)-192 source remains a cornerstone in the management of locally advanced cervical cancer. However, the accuracy of dose delivery depends critically on precise source positioning within the applicator geometry. This study aims to investigate the dosimetric impact of small positional deviations of a radioactive source within a 26-mm diameter ring applicator and assess how such deviations influence target coverage and doses to surrounding Organs...

Oncology 

Introduction: Prostate cancer (PC) is a malignant proliferation of prostate cells. Common screening methods, such as digital rectal examination and prostate-specific antigen (PSA) testing, lack accuracy. Magnetic resonance imaging (MRI) improves the detection, localization, and assessment of can-cer progression. The objective was to document the contribution of MRI in prostate cancer screening at the Imaging and Diagnostic Center of the Nation-al Social Security Fund (CNSS) in Guinea. Methods: D...

Oncology 

Uterine Adenomatoid Tumor (AT) is a rare benign mesothelial neoplasm, usually small and incidental. Large cystic presentations are exceptional and can mimic adnexal or uterine malignancy. The Leiomyoadenomatoid Tumor (LAT) variant combines mesothelial and smooth-muscle components, adding diagnostic difficulty. The Leiomyoadenomatoid Tumor (LAT) is a rare benign uterine lesion characterized by a proliferation of interlacing smooth muscle fibers admixed with glandular elements and fibrous tissue, ...

Oncology 

Adenoid cystic carcinoma (ACC) is a rare malignant neoplasm that primarily arises from the salivary glands. It accounts for approximately 10% of all salivary gland tumors and is the most common malignancy affecting the minor salivary glands. Nearly 50% of cases occur in intraoral sites, with a marked predilection for the hard palate. The parotid gland is the second most common location, followed by the submandibular gland. ACC typically affects individuals between the fourth and sixth decades of...

Dentistry  Oncology  Pathology 

Uterine smooth muscle tumors of uncertain malignant potential (STUMP) are rare tumors with histologic features of both benign leiomyoma and leiomyosarcoma. Due to this, their clinical behavior is unpredictable, and long-term outcomes of progressing into malignant leiomyosarcoma should be closely investigated. We present the case of a 42-year-old woman diagnosed with STUMP following laparoscopic-assisted myomectomy. Despite total abdominal hysterectomy and negative initial follow-up, she develope...

Gynecology & Obstetrics  Oncology  Women’s Health 

Background: The association of seminoma with malignant hypercalcemia is extremely rare. Case findings: We present a 32-year-old male with hypercalcemia. Subsequently, a metastatic seminoma was discovered according to computed tomography and biopsy testing. Elevated 1,25-dihydroxyvitamin D levels were identified as the cause of hypercalcemia. Conclusion: Hypercalcemia is a rare but possible scenario in seminoma and therefore it is important to consider this uncommon cause in the differential diag...

Oncology 

Accurate characterization of small radiation fields is essential for high-precision radiotherapy techniques such as Stereotactic Radiosurgery (SRS). This study evaluates the effectiveness of Full Width at Half Maximum (FWHM) analysis as a method for validating a Treatment Planning System (TPS), particularly for detector-dependent variations in small-field dosimetry. Beam profiles and percent depth dose (PDD) data were collected for field sizes ranging from 1 × 1 cm² to 4 × 4...

Oncology 

Male breast cancer (MBC) is a rare but impactful condition, constituting approximately 1% of all breast cancer cases. Due to its rarity, MBC often goes undiagnosed until later stages, and affected individuals face significant psychological and social challenges compounded by public misconceptions and a lack of tailored support. This study explores the emotional, psychological, and social impacts of MBC through a survey of 47 diagnosed male patients using validated assessment tools (HADS, IES-R, ...

Psychiatry & Psychology  Oncology 

Objective: The aim of the present study is to assess the role of the level of change in gene expression of the HOTAIR molecule in breast cancer patients. Methods: An assay was conducted for the level of gene expression of the HOTAIR molecule in the plasma of 30 patients and 10 healthy controls, by performing the reverse transcription reaction RT-qPCR, gene expression was evaluated using the Livak equation, tumor characteristics (grade, HER2 receptors, hormonal (...

Cell Biology  Oncology  Biochemistry 

Background: Glioblastoma is the most prevalent and aggressive primary malignant brain tumor, known for its rapid growth and local invasion. While it predominantly remains within the central nervous system, extracranial metastasis is extremely rare, involving the liver, lymph nodes, thorax, spleen, and bones. Thoracic involvement is often associated with the worst prognosis. Aim: This paper presents a unique case of lung metastasis from glioblastoma, highlighting...

Neurology  Oncology  Surgery & Surgical Specialties