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PLOS ONE

ISSN Print: 1932-6203

ISSN Online:

主页: http://www.plosone.org/

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Phase I Study of Cetuximab, Irinotecan, and Vandetanib (ZD6474) as Therapy for Patients with Previously Treated Metastastic Colorectal Cancer

Jeffrey A. Meyerhardt, Marek Ancukiewicz, Thomas A. Abrams, Deborah Schrag, Peter C. Enzinger, Jennifer A. Chan, Matthew H. Kulke, Brian M. Wolpin, Michael Goldstein, Lawrence Blaszkowsky, Andrew X. Zhu, Meaghan Elliott, Eileen Regan, Rakesh K. Jain, Dan G. Duda

The Lambeosaurine Dinosaur Magnapaulia laticaudus from the Late Cretaceous of Baja California, Northwestern Mexico

Albert Prieto-Márquez, Luis M. Chiappe, Shantanu H. Joshi

Pyrosequencing of Bacterial Symbionts within Axinella corrugata Sponges: Diversity and Seasonal Variability

James R. White, Jignasa Patel, Andrea Ottesen, Gabriela Arce, Patricia Blackwelder, Jose V. Lopez

Clustering by Plasma Lipoprotein Profile Reveals Two Distinct Subgroups with Positive Lipid Response to Fenofibrate Therapy

Kees van Bochove, Dani？l B. van Schalkwijk, Laurence D. Parnell, Chao-Qiang Lai, José M. Ordovás, Albert A. de Graaf, Ben van Ommen, Donna K. Arnett

Habitat Selection in a Rocky Landscape: Experimentally Decoupling the Influence of Retreat Site Attributes from That of Landscape Features

Benjamin M. Croak, David A. Pike, Jonathan K. Webb, Richard Shine

Eggs in the Freezer: Energetic Consequences of Nest Site and Nest Design in Arctic Breeding Shorebirds

Ingrid Tulp, Hans Schekkerman, Joep de Leeuw

Identifying Highly Connected Counties Compensates for Resource Limitations when Evaluating National Spread of an Invasive Pathogen

Sweta Sutrave, Caterina Scoglio, Scott A. Isard, J. M. Shawn Hutchinson, Karen A. Garrett

Evidence for Female-Biased Dispersal in the Protandrous Hermaphroditic Asian Seabass, Lates calcarifer

Gen Hua Yue, Jun Hong Xia, Feng Liu, Grace Lin

Contrasted Effects of Diversity and Immigration on Ecological Insurance in Marine Bacterioplankton Communities

Thierry Bouvier, Patrick Venail, Thomas Pommier, Corinne Bouvier, Claire Barbera, Nicolas Mouquet

A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway

Sebastián Zamorano, Diego Rojas-Rivera, Fernanda Lisbona, Valentina Parra, Felipe A. Court, Rosario Villegas, Emily H. Cheng, Stanley J. Korsmeyer, Sergio Lavandero, Claudio Hetz

Novel Strategy to Evaluate Infectious Salmon Anemia Virus Variants by High Resolution Melting

Dagoberto Sepúlveda, Constanza Cárdenas, Marisela Carmona, Sergio H. Marshall

A Highly Scalable Peptide-Based Assay System for Proteomics

Igor A. Kozlov, Elliot R. Thomsen, Sarah E. Munchel, Patricia Villegas, Petr Capek, Austin J. Gower, Stephanie J. K. Pond, Eugene Chudin, Mark S. Chee

Maternal Melatonin Programs the Daily Pattern of Energy Metabolism in Adult Offspring

Danilo S. Ferreira, Fernanda G. Amaral, Caroline C. Mesquita, Ana Paula L. Barbosa, Camilo Lellis-Santos, Ariane O. Turati, Laila R. Santos, Carolina S. Sollon, Patricia R. Gomes, Juliana A. Faria, José Cipolla-Neto, Silvana Bordin, Gabriel F. Anhê

Social Inequalities of Functioning and Perceived Health in Switzerland–A Representative Cross-Sectional Analysis

Jan D. Reinhardt, Erik von Elm, Christine Fekete, Johannes Siegrist

Water-Borne Cues of a Non-Indigenous Seaweed Mediate Grazer-Deterrent Responses in Native Seaweeds, but Not Vice Versa

Hee Young Yun, Aschwin H. Engelen, Rui O. Santos, Markus Molis

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

Deirdre M. Fuller, Minghua Zhu, Xiaohua Song, Chih-wen Ou-Yang, Sarah A. Sullivan, James C. Stone, Weiguo Zhang

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson’s Disease

Oi Wan Wan, Kenny K. K. Chung

Factors Associated with the Performance of a Blood-Based Interferon-γ Release Assay in Diagnosing Tuberculosis

Sally Banfield, Elaine Pascoe, Aesen Thambiran, Aris Siafarikas, David Burgner

Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients

Raquel Catarino, Ana Coelho, António Araújo, Mónica Gomes, Augusto Nogueira, Carlos Lopes, Rui Medeiros

An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud

Dolrudee Jumlongras, Salil A. Lachke, Daniel J. O’Connell, Anton Aboukhalil, Xiao Li, Sung E. Choe, Joshua W. K. Ho, Annick Turbe-Doan, Erin A. Robertson, Bjorn R. Olsen, Martha L. Bulyk, Brad A. Amendt, Richard L. Maas

Oxytocin and Vasopressin Are Dysregulated in Williams Syndrome, a Genetic Disorder Affecting Social Behavior

Li Dai, C. Sue Carter, Jian Ying, Ursula Bellugi, Hossein Pournajafi-Nazarloo, Julie R. Korenberg

Intrinsic Noise Analyzer: A Software Package for the Exploration of Stochastic Biochemical Kinetics Using the System Size Expansion

Philipp Thomas, Hannes Matuschek, Ramon Grima

Association of Polymorphisms in Oxidative Stress Genes with Clinical Outcomes for Bladder Cancer Treated with Bacillus Calmette-Guérin

Hua Wei, Ashish Kamat, Meng Chen, Hung-Lung Ke, David W. Chang, Jikai Yin, H. Barton Grossman, Colin P. Dinney, Xifeng Wu

Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation

Brante P. Sampey, Alex J. Freemerman, Jimmy Zhang, Pei-Fen Kuan, Joseph A. Galanko, Thomas M. O'Connell, Olga R. Ilkayeva, Michael J. Muehlbauer, Robert D. Stevens, Christopher B. Newgard, Heather A. Brauer, Melissa A. Troester, Liza Makowski

Ca2+ Regulates the Drosophila Stoned-A and Stoned-B Proteins Interaction with the C2B Domain of Synaptotagmin-1

Carolina Soekmadji, Clement Angkawidjaja, Leonard E. Kelly

Multi-Label Multi-Kernel Transfer Learning for Human Protein Subcellular Localization

Suyu Mei

Association of Sedentary Time with Mortality Independent of Moderate to Vigorous Physical Activity

Annemarie Koster, Paolo Caserotti, Kushang V. Patel, Charles E. Matthews, David Berrigan, Dane R. Van Domelen, Robert J. Brychta, Kong Y. Chen, Tamara B. Harris

Are Farm-Reared Quails for Game Restocking Really Common Quails (Coturnix coturnix)?: A Genetic Approach

Ines Sanchez-Donoso, Carles Vilà, Manel Puigcerver, Dalius Butkauskas, José Ramón Caballero de la Calle, Pablo Antonio Morales-Rodríguez, José Domingo Rodríguez-Teijeiro

Functional Remineralization of Dentin Lesions Using Polymer-Induced Liquid-Precursor Process

Anora K. Burwell, Taili Thula-Mata, Laurie B. Gower, Stefan Habeliz, Michael Kurylo, Sunita P. Ho, Yung-Ching Chien, Jing Cheng, Nancy F. Cheng, Stuart A. Gansky, Sally J. Marshall, Grayson W. Marshall

Associations between Ionomic Profile and Metabolic Abnormalities in Human Population

Liang Sun, Yu Yu, Tao Huang, Peng An, Danxia Yu, Zhijie Yu, Huaixing Li, Hongguang Sheng, Lu Cai, Jun Xue, Miao Jing, Yixue Li, Xu Lin, Fudi Wang

Implementation and Conduct of Therapeutic Hypothermia for Perinatal Asphyxial Encephalopathy in the UK – Analysis of National Data

Denis Azzopardi, Brenda Strohm, Louise Linsell, Anna Hobson, Edmund Juszczak, Jennifer J. Kurinczuk, Peter Brocklehurst, A. David Edwards, on behalf of the UK TOBY Cooling Register

Domestic Work and Psychological Distress？What Is the Importance of Relative Socioeconomic Position and Gender Inequality in the Couple Relationship?

Lisa Harryson, Mattias Strandh, Anne Hammarstr？m

Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers

Erhan Bilal, Kristen Vassallo, Deborah Toppmeyer, Nicola Barnard, Inga H. Rye, Vanessa Almendro, Hege Russnes, Anne-Lise B？rresen-Dale, Arnold J. Levine, Gyan Bhanot, Shridar Ganesan

The Structure of the Oligomerization Domain of Lsr2 from Mycobacterium tuberculosis Reveals a Mechanism for Chromosome Organization and Protection

Emma L. Summers, Kathrin Meindl, Isabel Usón, Alok K. Mitra, Mazdak Radjainia, Roberto Colangeli, David Alland, Vickery L. Arcus

Regulation of Classical Cadherin Membrane Expression and F-Actin Assembly by Alpha-Catenins, during Xenopus Embryogenesis

Sumeda Nandadasa, Qinghua Tao, Amanda Shoemaker, Sang-wook Cha, Christopher Wylie

Characterizing Interdisciplinarity of Researchers and Research Topics Using Web Search Engines

Hiroki Sayama, Jin Akaishi

Do Bat Gantries and Underpasses Help Bats Cross Roads Safely?

Anna Berthinussen, John Altringham

Cognitive Profile of Students Who Enter Higher Education with an Indication of Dyslexia

Maaike Callens, Wim Tops, Marc Brysbaert

The Adenomatous Polyposis Coli Protein Contributes to Normal Compaction of Mitotic Chromatin

Dina Dikovskaya, Guennadi Khoudoli, Ian P. Newton, Gaganmeet S. Chadha, Daniel Klotz, Ashwat Visvanathan, Angus Lamond, Jason R. Swedlow, Inke S. N？thke

Correlates of Poor Health among Orphans and Abandoned Children in Less Wealthy Countries: The Importance of Caregiver Health

Nathan Thielman, Jan Ostermann, Kathryn Whetten, Rachel Whetten, Karen O’Donnell, the Positive Outcomes for Orphans (POFO) Research Team

A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level

Jin Tian, Wenbao Qi, Xiaokang Li, Jun He, Peirong Jiao, Changhui Zhang, Guo-Qian Liu, Ming Liao

FRET-Based Localization of Fluorescent Protein Insertions Within the Ryanodine Receptor Type 1

Shweta A. Raina, Jeffrey Tsai, Montserrat Samsó, James D. Fessenden

Walking but Not Barking Improves Verb Recovery: Implications for Action Observation Treatment in Aphasia Rehabilitation

Paola Marangolo, Susanna Cipollari, Valentina Fiori, Carmela Razzano, Carlo Caltagirone

Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans

Daniel T. Omura, Damon A. Clark, Aravinthan D. T. Samuel, H. Robert Horvitz

Ectopic Expression of Neurogenin 2 Alone is Sufficient to Induce Differentiation of Embryonic Stem Cells into Mature Neurons

Eva C. Thoma, Erhard Wischmeyer, Nils Offen, Katja Maurus, Anna-Leena Sirén, Manfred Schartl, Toni U. Wagner

Stereological Analysis of Neuron, Glial and Endothelial Cell Numbers in the Human Amygdaloid Complex

María García-Amado, Lucía Prensa

The Physiology and Proteomics of Drought Tolerance in Maize: Early Stomatal Closure as a Cause of Lower Tolerance to Short-Term Dehydration?

Monika Bene？ová, Dana Holá, Luká？ Fischer, Petr L. Jedelsky, Franti？ek Hnili？ka, Na？a Wilhelmová, Olga Rothová, Marie Ko？ová, Dagmar Procházková, Jana Honnerová, Lenka Fridrichová, Helena Hnili？ková

Protein Sequence Alignment Analysis by Local Covariation: Coevolution Statistics Detect Benchmark Alignment Errors

Russell J. Dickson, Gregory B. Gloor

Effect of Recombinant Cytokines on the Expression of Natural Killer Cell Receptors from Patients with TB or/and HIV Infection

Venkata Ramana Rao Parasa, Rajasekaran Sikhamani, Alamelu Raja

Survival Analysis of Patients with Heart Failure: Implications of Time-Varying Regression Effects in Modeling Mortality

Suely Ruiz Giolo, José Eduardo Krieger, Alfredo José Mansur, Alexandre Costa Pereira

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