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PLOS ONE

ISSN Print: 1932-6203

ISSN Online:

主页: http://www.plosone.org/

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Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

Alessandro Spadaro, Matthias Negri, Sandrine Marchais-Oberwinkler, Emmanuel Bey, Martin Frotscher

A Low-Cost GPS GSM/GPRS Telemetry System: Performance in Stationary Field Tests and Preliminary Data on Wild Otters (Lutra lutra)

Lorenzo Quaglietta, Bruno Herlander Martins, Addy de Jongh, António Mira, Luigi Boitani

Impedance Responses Reveal β2-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles

Wayne Stallaert, Jonas F. Dorn, Emma van der Westhuizen, Martin Audet, Michel Bouvier

Isotropic 3D Nuclear Morphometry of Normal, Fibrocystic and Malignant Breast Epithelial Cells Reveals New Structural Alterations

Vivek Nandakumar, Laimonas Kelbauskas, Kathryn F. Hernandez, Kelly M. Lintecum, Patti Senechal, Kimberly J. Bussey, Paul C. W. Davies, Roger H. Johnson, Deirdre R. Meldrum

Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner

Christine W. Duarte, Christopher D. Willey, Degui Zhi, Xiangqin Cui, Jacqueline J. Harris, Laura Kelly Vaughan, Tapan Mehta, Raymond O. McCubrey, Nikolai N. Khodarev, Ralph R. Weichselbaum, G. Yancey Gillespie

Quantifying the Dynamics of Coupled Networks of Switches and Oscillators

Matthew R. Francis, Elana J. Fertig

Testing in Mice the Hypothesis That Melanin Is Protective in Malaria Infections

Michael Waisberg, Brandi K. Vickers, Stephanie B. Yager, Christina K. Lin, Susan K. Pierce

Large-Scale Pathway-Based Analysis of Bladder Cancer Genome-Wide Association Data from Five Studies of European Background

Idan Menashe, Jonine D. Figueroa, Montserrat Garcia-Closas, Nilanjan Chatterjee, Nuria Malats, Antoni Picornell, Dennis Maeder, Qi Yang, Ludmila Prokunina-Olsson, Zhaoming Wang, Francisco X. Real, Kevin B. Jacobs, Dalsu Baris, Michael Thun, Demetrius Albanes, Mark P. Purdue, Manolis Kogevinas, Amy Hutchinson, Yi-Ping Fu, Wei Tang, Laurie Burdette, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Josep Lloreta, Alison Johnson, Molly Schwenn, Alan Schned, Gerald Andriole, Amanda Black, Eric J. Jacobs, Ryan W. Diver, Susan M. Gapstur, Stephanie J. Weinstein, Jarmo Virtamo, Neil E. Caporaso, Maria Teresa Landi, Joseph F. Fraumeni, Stephen J. Chanock, Debra T. Silverman, Nathaniel Rothman

Depletion of B2 but Not B1a B Cells in BAFF Receptor-Deficient ApoE？/？ Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation

Tin Kyaw, Christopher Tay, Hamid Hosseini, Peter Kanellakis, Tahlia Gadowski, Fabeinne MacKay, Peter Tipping, Alex Bobik, Ban-Hock Toh

The Dopamine Augmenter L-DOPA Does Not Affect Positive Mood in Healthy Human Volunteers

John Liggins, Robert O. Pihl, Chawki Benkelfat, Marco Leyton

HIV Pol Inhibits HIV Budding and Mediates the Severe Budding Defect of Gag-Pol

Xin Gan, Stephen J. Gould

Profiling of Differentially Expressed Genes Using Suppression Subtractive Hybridization in an Equine Model of Chronic Asthma

Jean-Pierre Lavoie, Josiane Lefebvre-Lavoie, Mathilde Leclere, Anouk Lavoie-Lamoureux, Annie Chamberland, Catherine Laprise, Jacques Lussier

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation

Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Ziliang Ao, Lieping Chen, Dawei Ou, C. Bruce Verchere, Alice Mui, Garth L. Warnock

CATCHprofiles: Clustering and Alignment Tool for ChIP Profiles

Fiona G. G. Nielsen, Kasper Galschi？t Markus, Rune M？llegaard Friborg, Lene Monrad Favrholdt, Hendrik G. Stunnenberg, Martijn Huynen

Enhanced Fatty Acid Oxidation and FATP4 Protein Expression after Endurance Exercise Training in Human Skeletal Muscle

Jacob Jeppesen, Andreas B. Jordy, Kim A. Sj？berg, Joachim Füllekrug, Andreas Stahl, Lars Nybo, Bente Kiens

The Complete Mitochondrial Genome and Novel Gene Arrangement of the Unique-Headed Bug Stenopirates sp. (Hemiptera: Enicocephalidae)

Hu Li, Hui Liu, Aimin Shi, Pavel ？tys, Xuguo Zhou, Wanzhi Cai

IPET and FETR: Experimental Approach for Studying Molecular Structure Dynamics by Cryo-Electron Tomography of a Single-Molecule Structure

Lei Zhang, Gang Ren

Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

Antu K. Dey, Brian Burke, Yide Sun, Klara Sirokman, Avishek Nandi, Karin Hartog, Ying Lian, Anthony R. Geonnotti, David Montefiori, Michael Franti, Grégoire Martin, Andrea Carfi, Pascal Kessler, Lo？c Martin, Indresh K. Srivastava, Susan W. Barnett

Crosstalk between Virulence Loci: Regulation of Salmonella enterica Pathogenicity Island 1 (SPI-1) by Products of the std Fimbrial Operon

Javier López-Garrido, Josep Casadesús

Spread of Epidemic MRSA-ST5-IV Clone Encoding PVL as a Major Cause of Community Onset Staphylococcal Infections in Argentinean Children

Claudia Sola, Hugo Paganini, Ana L. Egea, Alejandro J. Moyano, Analia Garnero, Ines Kevric, Catalina Culasso, Ana Vindel, Study Group of CA-MRSA in Children, Argentina-2007 , Horacio Lopardo, José L. Bocco

Genomic and SNP Analyses Demonstrate a Distant Separation of the Hospital and Community-Associated Clades of Enterococcus faecium

Jessica Galloway-Pe？a, Jung Hyeob Roh, Mauricio Latorre, Xiang Qin, Barbara E. Murray

Facemasks, Hand Hygiene, and Influenza among Young Adults: A Randomized Intervention Trial

Allison E. Aiello, Vanessa Perez, Rebecca M. Coulborn, Brian M. Davis, Monica Uddin, Arnold S. Monto

TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

Jesus Segovia, Ahmed Sabbah, Victoria Mgbemena, Su-Yu Tsai, Te-Hung Chang, Michael T. Berton, Ian R. Morris, Irving C. Allen, Jenny P.-Y. Ting, Santanu Bose

Y Chromosome Lineages in Men of West African Descent

Jada Benn Torres, Menahem B. Doura, Shomarka O. Y. Keita, Rick A. Kittles

Isolation and Characterization of Intestinal Epithelial Cells from Normal and SIV-Infected Rhesus Macaques

Diganta Pan, Arpita Das, David Liu, Ronald S. Veazey, Bapi Pahar

Information Transmission in Cercal Giant Interneurons Is Unaffected by Axonal Conduction Noise

Zane N. Aldworth, John A. Bender, John P. Miller

Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat

Kazunori Takahashi, Hiroki Mizukami, Kosuke Kamata, Wataru Inaba, Noriaki Kato, Chihiro Hibi, Soroku Yagihashi

Influence of Antipsychotic Drugs on Human Endogenous Retrovirus (HERV) Transcription in Brain Cells

Olivia Diem, Marisa Sch？ffner, Wolfgang Seifarth, Christine Leib-M？sch

A Model for the Ultrastructure of Bone Based on Electron Microscopy of Ion-Milled Sections

Elizabeth A. McNally, Henry P. Schwarcz, Gianluigi A. Botton, A. Larry Arsenault

Comparing Statistical Methods for Constructing Large Scale Gene Networks

Jeffrey D. Allen, Yang Xie, Min Chen, Luc Girard, Guanghua Xiao

c-MET Protects Breast Cancer Cells from Apoptosis Induced by Sodium Butyrate

Bo Sun, Rui Liu, Zhong-Dang Xiao, Xuan Zhu

Immunological Evaluation of Lipopeptide Group A Streptococcus (GAS) Vaccine: Structure-Activity Relationship

Mehfuz Zaman, Abu-Baker M. Abdel-Aal, Yoshio Fujita, Karen S. M. Phillipps, Michael R. Batzloff, Michael F. Good, Istvan Toth

Paternity and Dominance Loss in Male Breeders: The Cost of Helpers in a Cooperatively Breeding Mammal

Sophie Lardy, Aurélie Cohas, Emmanuel Desouhant, Marion Tafani, Dominique Allainé

The Mycobacterial LysR-Type Regulator OxyS Responds to Oxidative Stress and Negatively Regulates Expression of the Catalase-Peroxidase Gene

Yuqing Li, Zheng-Guo He

Cord Blood Derived CD4+CD25high T Cells Become Functional Regulatory T Cells upon Antigen Encounter

Elisabeth Mayer, Christina Bannert, Saskia Gruber, Sven Klunker, Andreas Spittler, Cezmi A. Akdis, Zsolt Szépfalusi, Thomas Eiwegger

The Fitness Cost of Antibiotic Resistance in Streptococcus pneumoniae: Insight from the Field

M. Cyrus Maher, Wondu Alemayehu, Takele Lakew, Bruce D. Gaynor, Sara Haug, Vicky Cevallos, Jeremy D. Keenan, Thomas M. Lietman, Travis C. Porco

Dominant-Negative Androgen Receptor Inhibition of Intracrine Androgen-Dependent Growth of Castration-Recurrent Prostate Cancer

Mark A. Titus, Brian Zeithaml, Boris Kantor, Xiangping Li, Karin Haack, Dominic T. Moore, Elizabeth M. Wilson, James L. Mohler, Tal Kafri

The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures

Ashwini Kamath-Loeb, Lawrence A. Loeb, Michael Fry

Is There a Seamount Effect on Microbial Community Structure and Biomass? The Case Study of Seine and Sedlo Seamounts (Northeast Atlantic)

Ana Mendon？a,Javier Arístegui,Juan Carlos Vilas,Maria Fernanda Montero,Alicia Ojeda,Minerva Espino,Ana Martins

Reactive Oxygen Species Stimulate Insulin Secretion in Rat Pancreatic Islets: Studies Using Mono-Oleoyl-Glycerol

Marylana Saadeh, Thomas C. Ferrante, Ada Kane, Orian Shirihai, Barbara E. Corkey, Jude T. Deeney

14-3-3ζ Interacts with Stat3 and Regulates Its Constitutive Activation in Multiple Myeloma Cells

Jia Zhang,Fangjin Chen,Wenliang Li,Qian Xiong,Mingkun Yang,Peng Zheng,Chongyang Li,Jianfeng Pei,Feng Ge

A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

Fahd Al-Mulla,Milad S. Bitar,Jingwei Feng,Sungdae Park,Kam C. Yeung

Comparative Genomics and Drug Resistance of a Geographic Variant of ST239 Methicillin-Resistant Staphylococcus aureus Emerged in Russia

Tatsuo Yamamoto,Tomomi Takano,Wataru Higuchi,Yasuhisa Iwao,Olga Singur,Ivan Reva,Yuta Otsuka,Toru Nakayashiki,Hirotada Mori,Galina Reva,Vladimir Kuznetsov,Vladimir Potapov

Population-Based Incidence of Typhoid Fever in an Urban Informal Settlement and a Rural Area in Kenya: Implications for Typhoid Vaccine Use in Africa

Robert F. Breiman,Leonard Cosmas,Henry Njuguna,Allan Audi,Beatrice Olack,John B. Ochieng,Newton Wamola,Godfrey M. Bigogo,George Awiti,Collins W. Tabu,Heather Burke,John Williamson,Joseph O. Oundo,Eric D. Mintz,Daniel R. Feikin

Inhibition of Akt Activity and Calcium Channel Function Coordinately Drive Cell-Cell Fusion in the BeWO Choriocarcinoma Placental Cell Line

Manu Vatish,Lydia Tesfa,Dimitris Grammatopoulos,Eijiro Yamada,Claire C. Bastie,Jeffrey E. Pessin

Autocrine Prostaglandin E2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma

Agnes Rasmuson,Anna Kock,Ole Martin Fuskev？g,Bj？rn Kruspig,Jaione Simón-Santamaría,Vladimir Gogvadze,John Inge Johnsen,Per Kogner,Baldur Sveinbj？rnsson

RNA-Seq Based Transcriptional Map of Bovine Respiratory Disease Pathogen “Histophilus somni 2336”

Ranjit Kumar, Mark L. Lawrence, James Watt, Amanda M. Cooksey, Shane C. Burgess, Bindu Nanduri

Whom and Where Are We Not Vaccinating? Coverage after the Introduction of a New Conjugate Vaccine against Group A Meningococcus in Niger in 2010

Sung Hye Kim, Lorenzo Pezzoli, Harouna Yacouba, Tiekoura Coulibaly, Mamoudou H. Djingarey, William A. Perea, Thomas F. Wierzba

DNA Barcoding Bromeliaceae: Achievements and Pitfalls

Vitor Hugo Maia, Camila Souza da Mata, Luciana Ozório Franco, M？nica Aires Cardoso, Sérgio Ricardo Sodré Cardoso, Adriana Silva Hemerly, Paulo Cavalcanti Gomes Ferreira

Curcumin-Arteether Combination Therapy of Plasmodium berghei-Infected Mice Prevents Recrudescence Through Immunomodulation

Palakkod G. Vathsala, Chaitanya Dende, Viswanathan Arun Nagaraj, Debapriya Bhattacharya, Gobardhan Das, Pundi N. Rangarajan, Govindarajan Padmanaban

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