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PLOS ONE  2012 

Quantifying the Dynamics of Coupled Networks of Switches and Oscillators

DOI: 10.1371/journal.pone.0029497

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Abstract:

Complex network dynamics have been analyzed with models of systems of coupled switches or systems of coupled oscillators. However, many complex systems are composed of components with diverse dynamics whose interactions drive the system's evolution. We, therefore, introduce a new modeling framework that describes the dynamics of networks composed of both oscillators and switches. Both oscillator synchronization and switch stability are preserved in these heterogeneous, coupled networks. Furthermore, this model recapitulates the qualitative dynamics for the yeast cell cycle consistent with the hypothesized dynamics resulting from decomposition of the regulatory network into dynamic motifs. Introducing feedback into the cell-cycle network induces qualitative dynamics analogous to limitless replicative potential that is a hallmark of cancer. As a result, the proposed model of switch and oscillator coupling provides the ability to incorporate mechanisms that underlie the synchronized stimulus response ubiquitous in biochemical systems.

References

[1]  Glass L, Kauffman S (1973) The logical analysis of continuous, non-linear biochemical control networks. Journal of Theoretical Biology 39: 103–129.
[2]  Hopfield JJ (1982) Neural networks and physical systems with emergent collective computational abilities. Proc Natl Acad Sci U S A 79: 2554–8.
[3]  Shmulevich I, Dougherty ER, Zhang W (2002) From boolean to probabilistic boolean networks as models of genetic regulatory networks. Proceedings of the IEEE 90: 1778–1792.
[4]  Kuramoto Y (1975) International Symposium on Mathematical Problems in Theoretical Physics, volume 39 of Lecture Notes in Physics. Springer. 420 p.
[5]  Strogatz SH (2003) Sync: the emerging science of spontaneous order. New York: Hyperion, 1st ed edition. 338 p.
[6]  Garcia-Ojalvo J, Elowitz MB, Strogatz SH (2004) Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing. Proc Natl Acad Sci U S A 101: 10955–60.
[7]  Danino T, Mondrag?n-Palomino O, Tsimring L, Hasty J (2010) A synchronized quorum of genetic clocks. Nature 463: 326–30.
[8]  Tu BP, Kudlicki A, Rowicka M, McKnight SL (2005) Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Science 310: 1152–8.
[9]  Klevecz RR, Li CM, Marcus I, Frankel PH (2008) Collective behavior in gene regulation: the cell is an oscillator, the cell cycle a developmental process. FEBS J 275: 2372–84.
[10]  Huang S, Eichler G, Bar-Yam Y, Ingber D (2005) Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett 94: 128701.
[11]  Peskin C (1975) Mathematical Aspects of Heart Physiology. 278 p. Courant Institute Lecture Notes. Courant Institute of Mathematical Sciences.
[12]  Breakspear M, Heitmann S, Daffertshofer A (2010) Generative models of cortical oscillations: neurobiological implications of the kuramoto model. Front Hum Neurosci 4: 190.
[13]  Strogatz SH (1987) Human sleep and circadian rhythms: a simple model based on two coupled oscillators. J Math Biol 25: 327–47.
[14]  Fox JJ, Jayaprakash C, Wang D, Campbell SR (2001) Synchronization in relaxation oscillator networks with conduction delays. Neural Comput 13: 1003–21.
[15]  Cumin D, Unsworth C (2007) Generalizing the Kuramoto model for the study of neuronal synchronization in the brain. Physica D 226: 181–196.
[16]  Wang Q, Duan Z, Perc M, Chen G (2008) Synchronization transitions on small-world neuronal networks: Effects of information transmission delay and rewiring probability. EPL 83: 50008.
[17]  Pérez T, Garcia GC, Eguíluz VM, Vicente R, Pipa G, et al. (2011) Effect of the topology and delayed interactions in neuronal networks synchronization. PLoS One 6: e19900.
[18]  Kunysz A, Shrier A, Glass L (1997) The challenge of complex dynamics for theoretical models of cardiac activity. Journal of Theoretical Medicine 1: 79–90.
[19]  Chang HS, Staras K, Gilbey MP (2000) Multiple oscillators provide metastability in rhythm generation. J Neurosci 20: 5135–43.
[20]  Sato D, Xie LH, Sovari AA, Tran DX, Morita N, et al. (2009) Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias. Proc Natl Acad Sci U S A 106: 2983–8.
[21]  Zahanich I, Sirenko SG, Maltseva LA, Tarasova YS, Spurgeon HA, et al. (2011) Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and ca cycling. J Mol Cell Cardiol 50: 66–76.
[22]  Tiana-Alsina J, Garcia-Lopez JH, Torrent M, Garcia-Ojalvo J (2011) Dual-lag synchronization between coupled chaotic lasers due to path-delay interference. Chaos 21: 043102.
[23]  Mondal A, Sinha S, Kurths J (2008) Rapidly switched random links enhance spatiotemporal regularity. Phys Rev E Stat Nonlin Soft Matter Phys 78: 066209.
[24]  Sorrentino F, Ott E (2008) Adaptive synchronization of dynamics on evolving complex networks. Phys Rev Lett 100: 114101.
[25]  Jiang M, Ma P (2009) Coherence resonance induced by rewiring in complex networks. Chaos 19: 013115.
[26]  Volman V, Perc M (2010) Fast random rewiring and strong connectivity impair fast random rewiring and strong connectivity impair subthreshold signal detection in excitable networks. New Journal of Physics 12: 043013.
[27]  Adhikari BM, Prasad A, Dhamala M (2011) Time-delay-induced phase-transition to synchrony in coupled bursting neurons. Chaos 21: 023116.
[28]  G?omez-Gardees J, G?mez S, Arenas A, Moreno Y (2011) Explosive synchronization transitions in scale-free networks. Phys Rev Lett 106: 128701.
[29]  Martens E, Barreto E, Strogatz S, Ott E, So P, et al. (2009) Exact results for the kuramoto model with a bimodal frequency distribution. Phys Rev E 79: 026204.
[30]  Taylor D, Ott E, Restrepo JG (2010) Spontaneous synchronization of coupled oscillator systems with frequency adaptation. Phys Rev E Stat Nonlin Soft Matter Phys 81: 046214.
[31]  Ermentrout B, Ko TW (2009) Delays and weakly coupled neuronal oscillators. Philos Transact A Math Phys Eng Sci 367: 1097–115.
[32]  Wang Q, Perc M, Duan Z, Chen G (2009) Synchronization transitions on scale-free neuronal networks due to finite information transmission delays. Phys Rev E Stat Nonlin Soft Matter Phys 80: 026206.
[33]  Wang Q, Chen G, Perc M (2011) Synchronous bursts on scale-free neuronal networks with attractive and repulsive coupling. PLoS One 6: e15851.
[34]  Alon U (2007) Network motifs: theory and experimental approaches. Nat Rev Genet 8: 450–461.
[35]  Novak B, Tyson JJ (2008) Design principles of biochemical oscillators. Nat Rev Mol Cell Biol 9: 981–991.
[36]  Milo R, Shen-Orr S, Itzkovitz S, Kashtan N, Chklovskii D, et al. (2002) Network motifs: simple building blocks of complex networks. Science 298: 824–7.
[37]  Shen-Orr SS, Milo R, Mangan S, Alon U (2002) Network motifs in the transcriptional regulation network of escherichia coli. Nat Genet 31: 64–8.
[38]  Rao CV, Arkin AP (2001) Control motifs for intracellular regulatory networks. Annu Rev Biomed Eng 3: 391–419.
[39]  Prill RJ, Iglesias PA, Levchenko A (2005) Dynamic properties of network motifs contribute to biological network organization. PLoS Biol 3: e343.
[40]  Csikász-Nagy A, Novák B, Tyson JJ (2008) Reverse engineering models of cell cycle regulation. Adv Exp Med Biol 641: 88–97.
[41]  Purcell O, Savery NJ, Grierson CS, di Bernardo M (2010) A comparative analysis of synthetic genetic oscillators. J R Soc Interface 7: 1503–24.
[42]  Taylor D, Restrepo JG (2011) Network connectivity during mergers and growth: optimizing the addition of a module. Phys Rev E Stat Nonlin Soft Matter Phys 83: 066112.
[43]  Kim JR, Yoon Y, Cho KH (2008) Coupled feedback loops form dynamic motifs of cellular networks. Biophys J 94: 359–65.
[44]  Tyson JJ, Chen KC, Novak B (2003) Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15: 221–231.
[45]  Strogatz SH (2000) From Kuramoto to Crawford: exploring the onset of synchronization in populations of coupled oscillators. Physica D 143: 1–20.
[46]  Edwards R (2000) Analysis of continuous-time switching networks. Physica D 146: 165–199.
[47]  Tyson JJ, Chen K, Novak B (2001) Network dynamics and cell physiology. Nat Rev Mol Cell Biol 2: 908.
[48]  Hanahan D, Weinberg R (2000) The hallmarks of cancer. Cell 100: 57–70.
[49]  Restrepo JG, Ott E, Hunt B (2005) Onset of synchronization in large networks of coupled oscillators. Phys Rev E 71: 036151.
[50]  Restrepo JG, Ott E, Hunt B (2005) Synchronization in large directed networks of coupled phase oscillators. Chaos 16: 015107.
[51]  Restrepo JG, Ott E, Hunt B (2006) Emergence of coherence in complex networks of heterogeneous dynamical systems. Phys Rev Lett 96: 254103.
[52]  Restrepo JG, Ott E, Hunt B (2006) Emergence of synchronization in complex networks of interacting dynamical systems. Physica D 224: 114–122.
[53]  Barabási AL, Oltvai ZN (2004) Network biology: understanding the cell's functional organization. Nat Rev Genet 5: 101–13.
[54]  Pikovsky A, Zaikin A, de la Casa MA (2002) System size resonance in coupled noisy systems and in the ising model. Phys Rev Lett 88: 050601.
[55]  Dorogovtsev S (2010) Lectures on Complex Networks. Oxford University Press. 144 p.
[56]  Kaern M, Elston TC, Blake WJ, Collins JJ (2005) Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet 6: 451–464.
[57]  Stein RB, Gossen ER, Jones KE (2005) Neuronal variability: noise or part of the signal? Nat Rev Neurosci 6: 389–97.
[58]  Faisal AA, Selen LPJ, Wolpert DM (2008) Noise in the nervous system. Nat Rev Neurosci 9: 292–303.
[59]  Gillespie DT (2007) Stochastic simulation of chemical kinetics. Annu Rev Phys Chem 58: 35–55.
[60]  Fertig EJ, Danilova LV, Favorov AV, Ochs MF (2011) Hybrid modeling of cell signaling and transcriptional reprogramming and its application in c. elegans development. Frontiers in Bioinformatics and Computational Biology 2: 77.

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