OALib Journal
  OALib Journal is an all-in-one open access journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721). It accepts a manuscript for the peer-review processing, typesetting, publication and then allocated to one of the 322 subject areas. The article processing charge for publishing in OALib journal is Only $99. For more details, please contact service@oalib.com. Submit now
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Jan 18, 2023Open    AccessArticle

Vein of Galen Aneurysm as a Possible Cause of Congestive Heart Failure in the Neonatal Period: About 2 New Cases

Aliou Mar Coundoul, Sadio Konate, Modou Gueye, Amadou Lamine Fall, Amadou Sow, Papa Moctar Faye, Guilaye Diagne, Aminata Mbaye, Awa Kane, Mohameth Mbodj, Khadim Bop, Serigne Tawa Ndiaye, Papa Souleye Sow, Ndeye Fatou Sow, Mame Aita Seck, Mohamed Fattah, Ousmane Ndiaye
Aneurysm of the vein of Galen is a pseudo-aneurysmal dilation of the ampulla of Galen with one or more arteriovenous fistulas, discovered ante or postnatally. We report two cases for which the diagnoses of aneurysm of the vein of Galen were made in the neonatal period at 5 and 17 days of life in front of clinical signs of heart failure and an intracranial murmur. Cardiac ultrasound remains a tool that can guide the diagnosis objectifying the ascending diastolic flow at the level of the arch of t...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1108697


Jan 17, 2023Open    AccessArticle

Efficacy of Bevacizumab versus Epidermal Growth Factor Receptor Inhibitors for Ras Wild Type Metastatic Colorectal Cancer: A Real-World Data Analysis from a Tertiary Care Institution

Lamiae Amaadour, Soumia Berrad, Ibtissam El Harch, Karima Oualla, Samia Arifi, Karima El Ghazi, Laila Chbani, Zineb Benbrahim, Nawfel Mellas
Introduction: A combination of chemotherapy regimen and biologics in patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) resulted in improvements in survival. However, the optimal choice of initial biologic therapy in previously untreated patients remains challenging. Aim: The objective of this study is to compare the efficacy and safety outcomes of first-line epidermal growth factor receptor (EGFR) inhibitors versus vascular endothelial growth factor (VEGF) inhibitors in patien...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109293


Dec 31, 2022Open    AccessArticle

Dosimetric Evaluation of Treatment Plans of 3DCRT & IMRT in Prostate Cancer EBRT

Abdur Rehman, Muhammad Kamran Rasheed Nasir, Nouman Amjad, Babar Hussain
This study aims to compare 3DCRT & IMRT plans for two groups of prostate cancer patients i.e. “Prostate Only (PO) group” means the planning target volume includes the prostate & a margin of 1 cm from all sides except 0.6 cm from the posterior side & “Prostate Seminal Vesicles (PSV) group” means the PTV includes Prostate & Seminal Vesicles surrounded with a margin of 1 cm from all sides except 0.6 cm from the posterior side. Total of 17 patients has been studied. Among them, 9 patients belong t...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109591


Dec 23, 2022Open    AccessArticle

The Role of Autophagy in Acute Myeloid Leukemia

Siyu Zhou, Yu Wu, Yili Cai, Zecheng Yu, Ruirui Li, Chunwei Yan, Fangwei Dai, Wei Han
Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a po...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109476


Oct 21, 2022Open    AccessArticle

Breast Cancer during Pregnancy: A Case Report and Literature Review

Hamidou Soumana Diaouga, Maimouna Chaibou Yacouba, Madeleine Garba Rahamatou, Nafiou Idi, Madi Nayama
Breast cancer is the most common and deadliest cancer in women. The association of breast cancer and pregnancy is relatively rare and has a poor prognosis due to often late diagnosis and a high potential for lymphatic dissemination. It poses many diagnostic, therapeutic, prognostic and psychological problems. We report a case of ductal carcinoma of the breast associated with pregnancy in a 27-year-old patient. The diagnosis was late as well as the care which began 4 weeks after delivery. Obstetr...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109387


Aug 19, 2022Open    AccessArticle

The Breast Enriched HER2 Molecular Subtype-Like Salivary Duct Carcinoma: A Good Response to Novel Targeted Therapy in Two Advanced Disease Cases

Kien Hung Do, Tu Anh Do, Duc Thanh Le, Tai Van Nguyen, Chu Van Nguyen
Background: Salivary duct carcinoma (SDC) is one of the most aggressive malignant salivary gland tumors resembling high-grade mammary ductal carcinoma, with frequent local recurrence and regional lymph node and distant metastasis. SDC is often the absence of estrogen receptor and progesterone receptor, and Her2/neu overexpression. Treatment with molecular targeted therapy correlated well with long-term survival and therapeutic response in SDC patients. Purpose: We presented the clinicopathologic...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109089


Jun 29, 2022Open    AccessArticle

Neuroendocrine Carcinoma of the Cecum

Hicham Krimou, Nizar Errabi, Mohammed Cisse, Abdessamad El Kaoukabi, Adil Boudhas, Belhamidi Said, Mohammed Menfaa, Samir Hasbi, Fouad Sakit, Abdelkarim Choho
Neuroendocrine carcinoma (NEC) is a malignant tumor with a poor prognosis and can grow at many different sites in the body, but the colon is a very rare site. Clinical Case: We report a case of a 62-year-old man operated on for a tumor of the cecum, which was diagnosed as a high-grade neuroendocrine carcinoma. An immunohistochemical study showed positive marking with synaptophysin. No cancer metastasis was found. Postoperative chemotherapy was applied but the patient died after ...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108902


Jun 22, 2022Open    AccessArticle

Presentation of Pott’s Puffy Tumour in a 71-Year-Old Man wth Atypical History

Sapna Shivdas, Andrew Beynon Philips
Pott’s puffy tumour is a subperiosteal abscess of the frontal bone with osteomyelitis which has become rare because of the widespread use of antibiotics [1]. It is usually seen as a complication of frontal sinusitis [2]. Here we report a case of Pott’s puffy tumour (PPT) in a 71-year-old man who visited the accident & emergency department with painful swelling of the forehead but with no reported antecedent history of any symptoms of rhinitis or sinusitis. The application of a high index of clin...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108734


Feb 21, 2022Open    AccessArticle

Choledochal Cysts Diagnosis and Treatments: Case Report

Mohamed Noaman Al-Ba’adani, Saleh Ahmed Alammari, Najwa Aziz Jumman
Choledochal cyst is a rare pathological condition, which represents 1% of benign diseases of the biliary tract. It is seen with significant frequency in childhood, with a higher prevalence in females. Diagnosis is primarily based on clinical suspicion. Its symptoms are variable and its treatment, depending on the type, is surgical. Case Report: A 5-year-old female childhood, weighing 20 kg presented with a two weeks history of upper abdominal pain, jaundice and low-grade fever for 8 days, accomp...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1107382


Oct 12, 2021Open    AccessArticle

Giant Lipoma of the Scalp in Aba, South East Nigeria: A Case Report

Ndukauba Eleweke
Lipomas are ubiquitous soft tissue swellings that can be found in any part of the body. They are the commonest non-malignant tumours of the fatty tissue with varying sizes. When they are more than 10 cm in size along any dimension or weigh more than 1000 g, they are described as giant lipomas. I present a case of giant lipoma of the scalp, managed in Jonex Hospital, Aba, Nigeria. After clinical and relevant radiological investigations to characterize and ascertain the extent of the scalp lesion,...
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107898


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