Aneurysm of the vein of Galen is a pseudo-aneurysmal dilation of the ampulla of Galen with one or more arteriovenous fistulas, discovered ante or postnatally. We report two cases for which the diagnoses of aneurysm of the vein of Galen were made in the neonatal period at 5 and 17 days of life in front of clinical signs of heart failure and an intracranial murmur. Cardiac ultrasound remains a tool that can guide the diagnosis objectifying the ascending diastolic flow at the level of the arch of t...

Oncology 

Introduction: A combination of chemotherapy regimen and biologics in patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) resulted in improvements in survival. However, the optimal choice of initial biologic therapy in previously untreated patients remains challenging. Aim: The objective of this study is to compare the efficacy and safety outcomes of first-line epidermal growth factor receptor (EGFR) inhibitors versus vascular endothelial growth factor (VEGF) inhibitors in patien...

Oncology 

This study aims to compare 3DCRT & IMRT plans for two groups of prostate cancer patients i.e. “Prostate Only (PO) group” means the planning target volume includes the prostate & a margin of 1 cm from all sides except 0.6 cm from the posterior side & “Prostate Seminal Vesicles (PSV) group” means the PTV includes Prostate & Seminal Vesicles surrounded with a margin of 1 cm from all sides except 0.6 cm from the posterior side. Total of 17 patients has been studied. Among them, 9 patients belong t...

Oncology 

Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a po...

Cell Biology  Oncology 

Breast cancer is the most common and deadliest cancer in women. The association of breast cancer and pregnancy is relatively rare and has a poor prognosis due to often late diagnosis and a high potential for lymphatic dissemination. It poses many diagnostic, therapeutic, prognostic and psychological problems. We report a case of ductal carcinoma of the breast associated with pregnancy in a 27-year-old patient. The diagnosis was late as well as the care which began 4 weeks after delivery. Obstetr...

Gynecology & Obstetrics  Oncology  Women’s Health 

Background: Salivary duct carcinoma (SDC) is one of the most aggressive malignant salivary gland tumors resembling high-grade mammary ductal carcinoma, with frequent local recurrence and regional lymph node and distant metastasis. SDC is often the absence of estrogen receptor and progesterone receptor, and Her2/neu overexpression. Treatment with molecular targeted therapy correlated well with long-term survival and therapeutic response in SDC patients. Purpose: We presented the clinicopathologic...

Oncology 

Neuroendocrine carcinoma (NEC) is a malignant tumor with a poor prognosis and can grow at many different sites in the body, but the colon is a very rare site. Clinical Case: We report a case of a 62-year-old man operated on for a tumor of the cecum, which was diagnosed as a high-grade neuroendocrine carcinoma. An immunohistochemical study showed positive marking with synaptophysin. No cancer metastasis was found. Postoperative chemotherapy was applied but the patient died after ...

Oncology  Surgery & Surgical Specialties 

Pott’s puffy tumour is a subperiosteal abscess of the frontal bone with osteomyelitis which has become rare because of the widespread use of antibiotics [1]. It is usually seen as a complication of frontal sinusitis [2]. Here we report a case of Pott’s puffy tumour (PPT) in a 71-year-old man who visited the accident & emergency department with painful swelling of the forehead but with no reported antecedent history of any symptoms of rhinitis or sinusitis. The application of a high index of clin...

Oncology 

Choledochal cyst is a rare pathological condition, which represents 1% of benign diseases of the biliary tract. It is seen with significant frequency in childhood, with a higher prevalence in females. Diagnosis is primarily based on clinical suspicion. Its symptoms are variable and its treatment, depending on the type, is surgical. Case Report: A 5-year-old female childhood, weighing 20 kg presented with a two weeks history of upper abdominal pain, jaundice and low-grade fever for 8 days, accomp...

Oncology  Surgery & Surgical Specialties 

Lipomas are ubiquitous soft tissue swellings that can be found in any part of the body. They are the commonest non-malignant tumours of the fatty tissue with varying sizes. When they are more than 10 cm in size along any dimension or weigh more than 1000 g, they are described as giant lipomas. I present a case of giant lipoma of the scalp, managed in Jonex Hospital, Aba, Nigeria. After clinical and relevant radiological investigations to characterize and ascertain the extent of the scalp lesion,...

Oncology