Objective: The aim of the present study is to assess the role of the level of change in gene expression of the HOTAIR molecule in breast cancer patients. Methods: An assay was conducted for the level of gene expression of the HOTAIR molecule in the plasma of 30 patients and 10 healthy controls, by performing the reverse transcription reaction RT-qPCR, gene expression was evaluated using the Livak equation, tumor characteristics (grade, HER2 receptors, hormonal (HR) receptors) were also studied in the Pathological Anatomy Department and compared between patients. Results: The results of the study showed that there was a significant difference (P ＜ 0.05) in the level of change in gene expression between the patients and controls. There was a correlation between the level of change in gene expression and tumor grade, positivity for HER2 receptors and negativity for HR receptors. Conclusion: It was found that the gene expression level of HOTAIR molecule may have a prognostic significance in the diagnosis of breast cancer and the characteristics of the tumor responsible for increasing tumor virulence and poor prognosis.
Cite this paper
Redwan, F. , Abdullaa, N. , Alshatti, E. and Abdullah, A. (2025). The Predictive Role of LncRNA Molecules (HOTAIR) in Breast Cancer Prognosis. Open Access Library Journal, 12, e2993. doi: http://dx.doi.org/10.4236/oalib.1112993.
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