OALib Journal
  OALib Journal is an all-in-one open access journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721). It accepts a manuscript for the peer-review processing, typesetting, publication and then allocated to one of the 322 subject areas. The article processing charge for publishing in OALib journal is Only $99. For more details, please contact service@oalib.com. Submit now
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May 24, 2024Open    Access

Xeroderma Pigmentosum and Acute Lymphoblastic Leukemia: A Case Report

Hasnae Elhaddadi,Ayyad Ghanam,Aziza Elouali,Abdeladim Babakhouya,Maria Rkain,Noufissa Benajiba
Background: Xeroderma pigmentosum (XP) is a group of rare diseases resulting in most cases from a dysfunction of nucleotide excision repair (NER). It is characterized by extreme hypersensitivity to ultraviolet rays and predisposes to malignant skin tumors that can appear as early as childhood. XP is rarely associated with internal neoplasms such as acute lymphoblastic leukemia. Case Report: A 5-year-old Moroccan Girl, a xeroderma pigmentosum patient, was diagnos...
Open Access Library J.   Vol.11, 2024

Jul 21, 2023Open    Access

Atopic Dermatitis Related to RNF31 Genetic Variant

César Daniel Alonso-Bello, Sonia del Carmen Chávez-Ocana, Carol Vivian Moncayo-Coello, María Isabel Rojo-Gutierrez
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Open Access Library J.   Vol.10, 2023

Aug 20, 2021Open    Access

Prediction of the Active Ingredients and Mechanism of ASH against Liver Cancer Based on Network Pharmacology and Molecular Docking

Wenhua Guo, Kun Zhang, Luhong Yang
The network pharmacology and molecular docking technology were used to elucidate the mechanism of Artemisiae scopariae Herba (ASH) against liver cancer (LC). TCMSP and UniProt database were used to collect the active ingredients of ASH and predict their potential targets. The targets of LC were screened by GeneCards, OMIM and TTD database. The intersections of drug and disease targets were obtained by online software Venny 2.1, and the intersection targets were imported into R software (v3.6.3) ...
Open Access Library J.   Vol.8, 2021

Mar 05, 2021Open    Access

Comparative Studies on the Effects of High Sound Levels on the Haematological Parameters and Antioxidant Levels of Wistar Albino Rats

Chinedu P. Nwuke, Ibeh Bartholomew, Chibuike Daniel Peter
This is a detailed experimental and comparative study evaluating the harmful effects of graded loud noise on hematological and antioxidant in Wistar albino rats. Wistar albino rats were divided into a control group (those kept away from the noise due to a generator set), groups 1 (exposed to varied, 85 - 105 db levels of loud noise from a generator) and groups 2 (exposed to less, 40 - 55 db levels of loud noise from generator set) and exposed to way off fumes from electrical generator sounds at ...
Open Access Library J.   Vol.8, 2021

Sep 22, 2020Open    Access

The Fundamentals to Minimize the Culture Failure in Hematological Malignancies

Sumithra Martinovic, Bhanu Prakash Lalkota, Mithua Ghosh, Belagutty Jayappa Srinivasa, Prasanna Kumari
Cytogenetics plays a major role in Cancer studies, as some abnormalities aid in the correct categorizing of leukemia and lymphomas, and additionally provides important prognostic information. Though every laboratory follows SOP’s, there is always a chance of culture failure. We processed and analyzed 36 BMA (Bone marrow aspirate) and 31 PB samples (Peripheral blood) with referral reasons: Acute lymphoblastic leukemia (ALL) n = 37, Chronic lymphocytic leukemia (CLL) n = 7, Acute myeloid leukemia ...
Open Access Library J.   Vol.7, 2020

Sep 30, 2019Open    Access

Case Report-Huge Lipoma in the Right Groin

Abdulla Mohammed Megally, M. A. Al-Katta, Z. A. Mejalli, Hadi Mohammed Mujlli
Lipoma is the most common soft tissue tumor, considered the universal tumor in the body. The differential diagnosis of a lipoma in the groin will include groin hernias, safina varex, lymphadenopathy, hydrocele and sarcoma. Due to the similarity of clinical symptoms and signs, the differentiation between inguinal, femoral hernias and groin lipoma is difficult. To avoid the high risk of intraoperative complica
Open Access Library J.   Vol.6, 2019

Jun 30, 2017Open    Access

Chinese Acupuncture in Treatment of Bell’s Palsy Clinical Study

Hadi Mohammed Mujlli, Abdulraman Sallam Alkubaty
Objective: To observe the therapeutic effects of acupuncture for treatment of different stages of Acute Bell’s palsy, and its relationship to age and sex. Patients and Methods: 152 patients of Bell’s palsy, were acute cases in different grade of paralysis. Following up with combined drugs and acupuncture therapy for one month, which were diagnosed clinically and proved by electromyography EMG, these cases of acu
Open Access Library J.   Vol.4, 2017

Nov 25, 2016Open    Access

The Association between the KLF14 rs4731702 SNP and the Lipid Profile in Type 2 Diabetes Mellitus Patients: A Study in San Luis City, San Luis, Argentina

Micaela Fernanda álvarez, Miriam Ester Vásquez Gómez, Irma Inés González, Gustavo Fernández, Susana Siewert
The single nucleotide polymorphism (SNP) rs4731702 in the KLF14 transcription factor gene has been associated with type 2 diabetes mellitus (T2DM) and HDL-c concentrations. The aim of the present study was to determine the distribution of KLF14 rs4731702 SNP and evaluate the association betwee
Open Access Library J.   Vol.3, 2016

Oct 23, 2014Open    Access

FABP-2 and PPAR-γ Haplotype as Risk Factors for Dyslipidemia in a Type 2 Diabetes Mellitus Population of Santa Rosa del Conlara, San Luis, Argentina

Susana Siewert, María Florencia Olmos Nicotra, Irma Ines Gonzalez, Gustavo Fernandez, Marta Susana Ojeda
Introduction: Type 2 Diabetes Mellitus (T2DM) is a complex disorder caused by the interaction between genetic predisposition and environmental factors. Genetics plays an important role on lipid homeostasis. Many genes are involved in the lipid metabolism, such as FABP-2 and PPAR-γ. Aim: To evaluate the association between specific SNPs and haplotypes of the FABP-2 and PPAR-γ genes with T2DM and lipid profile in an Argentinean population. Methods: The FABP-2 (rs1799883) and PPAR-...
Open Access Library J.   Vol.1, 2014

Jun 18, 2014Open    Access

Identifying the Roles of Interleukin-13 in Childhood Asthma

Kamleshun Ramphul
Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow obstruction and airway hyperresponsiveness. While recent research has mapped several genes as possible factors predisposing to asthma, interleukin-13 remains one of the most commonly found genes in various populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause an increase in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness and s...
Open Access Library J.   Vol.1, 2014


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