全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

The Association between the KLF14 rs4731702 SNP and the Lipid Profile in Type 2 Diabetes Mellitus Patients: A Study in San Luis City, San Luis, Argentina

DOI: 10.4236/oalib.1103188, PP. 1-14

Subject Areas: Medical Genetics

Keywords: KLF14, Single Nucleotide Polymorphism, Type 2 Diabetes Mellitus, Lipid Profile, Dyslipidemia

Full-Text   Cite this paper   Add to My Lib

Abstract

The single nucleotide polymorphism (SNP) rs4731702 in the KLF14 transcription factor gene has been associated with type 2 diabetes mellitus (T2DM) and HDL-c concentrations. The aim of the present study was to determine the distribution of KLF14 rs4731702 SNP and evaluate the association between this SNP and serum lipid profile in T2DM patients in a patient population at San Luis province, Argentina. A total of 73 volunteers (26 T2DM patients and 47 healthy age-matched controls) were genotyped for KLF14 rs4731702 SNP by Tetra Primer ARMS-PCR. The KLF14 genotypes distribution among study groups was not significantly different. In T2DM patients, there was a difference in HDL-c values and TC/HDL-c ratio, with T carriers of the rs4731702 SNP (non C/C) having higher HLD-c and lower TC/HDL-c ratio values than C/C homozygotes (p = 0.0047 and 0.0041, respectively). HDL-c levels were higher in diabetic patients, without dyslipidemia, carrying the genotype non- C/C (p = 0.023). Conversely, TC and LDL-c levels were lower in diabetic patients, without dyslipidemia, in non-C/C carriers (p < 0.001). The results of the current study showed that T2DM is characterized by dyslipidemia, and that the alterations observed in the lipoprotein might be related to lower KLF14 activity in diabetic patients as a consequence of C/C genotype and insulin resistance.

Cite this paper

álvarez, M. F. , Gómez, M. E. V. , González, I. I. , Fernández, G. and Siewert, S. (2016). The Association between the KLF14 rs4731702 SNP and the Lipid Profile in Type 2 Diabetes Mellitus Patients: A Study in San Luis City, San Luis, Argentina. Open Access Library Journal, 3, e3188. doi: http://dx.doi.org/10.4236/oalib.1103188.

References

[1]  Scully, T. (2012) Diabetes in Numbers. Nature, 485, S2-S3.
https://doi.org/10.1038/485S2a
[2]  Lusis, A.J., Attie, A.D. and Reue, K. (2008) Metabolic Syndrome: From Epidemiology to Systems Biology. Nature Reviews Genetics, 9, 819-830.
https://doi.org/10.1038/nrg2468
[3]  Chasman, D.I., Paré, G., Mora, S., Hopewell, J.C., Peloso, G., Clarke, R., et al. (2009) Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis. PLoS Genetics, 5, e1000730.
https://doi.org/10.1371/journal.pgen.1000730
[4]  Teslovich, T.M., Musunuru, K., Smith, A.V., Edmondson, A.C., Stylianou, I.M., Koseki, M., et al. (2010) Biological, Clinical and Population Relevance of 95 Loci for Blood Lipids. Nature, 466, 707-713.
https://doi.org/10.1038/nature09270
[5]  Chen, X., Li, S., Yang, Y., Yang, X., Liu, Y., Liu, Y., et al. (2012) Genome-Wide Association Study Validation Identifies Novel Loci for Atherosclerotic Cardiovascular Disease. Journal of Thrombosis and Haemostasis, 10, 1508-1514.
https://doi.org/10.1111/j.1538-7836.2012.04815.x
[6]  Huang, P., Yin, R.X., Huang, K.K., Zeng, X.N., Guo, T., Lin, Q.Z., et al. (2013) Association of the KLF14 rs4731702SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations. BioMed Research International, 2013, Article ID: 231515.
https://doi.org/10.1155/2013/231515
[7]  de Assuncao, T.M., Lomberk, G., Cao, S., Yaqoob, U., Mathison, A., Simonetto, D.A., et al. (2014) New Role for Kruppel-Like Factor 14 as a Transcriptional Activator Involved in the Generation of Signaling Lipids. Journal of Biological Chemistry, 289, 15798-15809.
https://doi.org/10.1074/jbc.M113.544346
[8]  McConnell, B.B. and Yang, V.W. (2010) Mammalian Kruppel Like Factors in Health and Diseases. Physiological Reviews, 90, 1337-1381.
https://doi.org/10.1152/physrev.00058.2009
[9]  Small, K.S., Hedman, A.K., Grundberg, E., Nica, A.C., Thorleifsson, G., Kong, A., et al. (2011) Identification of an Imprinted Master Trans Regulator at the KLF14 Locus Related to Multiple Metabolic Phenotypes. Nature Genetics, 43, 561-564.
https://doi.org/10.1038/ng.833
[10]  Voight, B.F., Scott, L.J., Steinthorsdottir, V., Morris, A.P., Dina, C., Welch, R.P., et al. (2010) Twelve Type 2 Diabetes Susceptibility Loci Identified through Large-Scale Association Analysis. Nature Genetics, 42, 579-589.
https://doi.org/10.1038/ng.609
[11]  Kong, A., Steinthorsdottir, V., Masson, G., Thorleifsson, G., Sulem, P. and Besenbacher, S. (2009) Parental Origin of Sequence Variants Associated with Complex Diseases. Nature, 462, 868-874.
https://doi.org/10.1038/nature08625
[12]  Seino, Y., Nanjo, K., Tajima, N., Kadowaki, T., Kashiwagi, A., Araki, E., et al. (2010) Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus. Journal of Diabetes Investigation, 1, 212-228.
https://doi.org/10.1007/s13340-010-0006-7
[13]  Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (1998) The Evidence Report. National Institutes of Health. Obesity Research, 6, 51S-209S.
[14]  Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972) Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, without Use of the Preparative Ultracentrifuge. Clinical Chemistry, 18, 499-502.
[15]  Expert Panel on Detection (2001) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults: Executive Summary of the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel I II). Journal of the American Medical Association, 285, 2486-2497.
https://doi.org/10.1001/jama.285.19.2486
[16]  American Diabetes Association (2003) Management of Dyslipidemia in Adults With Diabetes. Diabetes Care, 26, s83-s86.
https://doi.org/10.2337/diacare.26.2007.S83
[17]  Rye, K.A. and Barter, P.J. (2004) Formation and Metabolism of Prebeta Migrating, Lipid Poor Apolipoprotein A-I. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 421-428.
https://doi.org/10.1161/01.ATV.0000104029.74961.f5
[18]  Steiner, G. and Vranic, M. (1982) Hyperinsulinemia and Hypertriglyceridemia a Vicious Cycle with Atherogenic Potential. International Journal of Obesity, 6, 117-124.
[19]  Li, N., Fu, J., Koonen, D.P., Kuivenhoven, J.A., Snieder, H. and Hofker, M.H. (2014) Are Hypertriglyceridemia and Low HDL Causal Factors in the Development of Insulin Resistance? Atherosclerosis, 233, 130-138.
https://doi.org/10.1016/j.atherosclerosis.2013.12.013
[20]  Kontush, A. and Chapman, M.J. (2006) Functionally Defective HDL: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation and Atherosclerosis. Pharmacological Reviews, 58,342-374.
https://doi.org/10.1124/pr.58.3.1
[21]  McLaughlin, T., Reaven, G., Abbasi, F., Lamendola, C., Saad, M., Waters, D., et al. (2005) Is There a Simple Way to Identify Insulin-Resistant Individuals at Increased Risk of Cardiovascular Disease? American Journal of Cardiology, 96, 399-404.
https://doi.org/10.1016/j.amjcard.2005.03.085
[22]  Civelek, M. and Lusis, A.J. (2011) Conducting the Metabolic Syndrome Orchestra. Nature Genetics, 43, 506-508.
https://doi.org/10.1038/ng.842
[23]  Guo, Y., Fan, Y., Zhang, J., Lomberk, G.A., Zhou, Z., Sun, L., et al. (2015) Perhexiline Activates KLF14 and Reduces Atherosclerosis by Modulating ApoA-I Production. Journal of Clinical Investigation, 125, 3819-3830.
https://doi.org/10.1172/JCI79048
[24]  Yang, M., Ren, Y., Lin, Z., Tang, C., Jia, Y., Lai, Y., et al. (2015) Krüppel-Like Factor 14 Increases Insulin Sensitivity through Activation of PI3K/Akt Signal Pathway. Cell Signaling, 27, 2201-2208.
https://doi.org/10.1016/j.cellsig.2015.07.019
[25]  Amatruda, J.M., Newmeyer, H.W. and Chang, C.L. (1982) Insulin-Induced Alterations in Insulin Binding and Insulin Action in Primary Cultures of Rat Hepatocytes, Diabetes, 31, 145-148.
https://doi.org/10.2337/diab.31.2.145

Full-Text


comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413