The Association between the KLF14 rs4731702 SNP and the Lipid Profile in Type 2 Diabetes Mellitus Patients: A Study in San Luis City, San Luis, Argentina
The
single nucleotide polymorphism (SNP) rs4731702 in the KLF14 transcription factor gene has
been associated with type 2 diabetes mellitus (T2DM) and HDL-c concentrations. The aim of the present study was to
determine the distribution of KLF14
rs4731702 SNP and evaluate the association between this SNP and serum lipid
profile in T2DM patients in a patient population at San Luis province,
Argentina. A total of 73 volunteers (26 T2DM
patients and 47 healthy age-matched controls)were genotyped for KLF14 rs4731702 SNP by Tetra Primer
ARMS-PCR. The KLF14 genotypes
distribution among study groups was not significantly different. In T2DM
patients, there was a difference in HDL-c values and TC/HDL-c ratio, with T
carriers of the rs4731702 SNP (non C/C)
having higher HLD-c and lower TC/HDL-c ratio values than C/C homozygotes (p = 0.0047 and 0.0041, respectively). HDL-c levels were higher in diabetic patients, without
dyslipidemia, carrying the genotype non- C/C (p = 0.023). Conversely, TC and LDL-c levels were lower in diabetic patients, without dyslipidemia, in non-C/C
carriers (p < 0.001). The results of the current study showed that T2DM is characterized by dyslipidemia, and that the
alterations observed in the lipoprotein might be related to lower KLF14 activity in diabetic patients as a
consequence of C/C genotype and insulin resistance.
Cite this paper
álvarez, M. F. , Gómez, M. E. V. , González, I. I. , Fernández, G. and Siewert, S. (2016). The Association between the KLF14 rs4731702 SNP and the Lipid Profile in Type 2 Diabetes Mellitus Patients: A Study in San Luis City, San Luis, Argentina. Open Access Library Journal, 3, e3188. doi: http://dx.doi.org/10.4236/oalib.1103188.
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