OALib Journal
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Jun 11, 2020Open    AccessArticle

Evaluating the Protective and Ameliorative Potential of Unripe Palm Kernel Seeds on Monosodium Glutamate-Induced Uterine Fibroids

Orinamhe Godwin Agbadua, Lilian Etinosa Idusogie, Amadi Samuel Chukwuebuka, Chukwu Sunday Nnamdi, Samuel Sylvester
The study investigated the protective and curative effects of unripe palm kernel seeds on monosodium glutamate-induced uterine fibroid in rats. The rats were in eight experimental groups according to the time of administration of the unripe palm kernel seeds: the first four groups investigated protective effects of UPK for 28 days and the last four groups investigated the curative effects of UPK after treatment with MSG for 28 days. MSG was administered to the animals by oral gavage at a dose of...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106461


May 08, 2020Open    AccessArticle

Evaluation of Antimicrobial Activities and Bioactive Compounds of Different Extracts Related to Syrian Traditional Products of Damask Rose (Rosa damascena)

Nasser Thallaj, Mohamed Isam Hasan Agha, Abdul Hakim Nattouf, Chadi Khatib, Ahmad Karaali, Aoula Moustapha, Louay Labban
Rosa damascena or Damask rose is an aromatic shrub-like plant which has been originated from Damascus region. This flower has been used in traditional medicine and traditional cuisine for centuries. Different extracts have been prepared from its flowers as essential oils, rose water or jams. Very recently, UNESCO has inscribed the element of the Damascus rose or Rosa damascena and associated heritage practices and craftsmanship on the UNESCO Intangible Cultural Heritage of Humanity list for its ...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106302


Mar 05, 2018Open    AccessArticle

Bioactive Constituents of Methanol Extract of Xylopia aethiopica (UDA) Fruits from Nsukka, Enugu State, Nigeria

Innocent Uzochukwu Okagu, Uchenna Ekpereamaka Ngwu, Chinyere Jane Odenigbo
The bioactive compounds in methanol extract of Xylopia aethiopica fruits were determined using a combination of gas chromatography and mass spectrometry (GC-MS). The compound identification was based on the molecular structure, molecular mass and calculated fragments. Interpretation on mass spectrum of GC-MS analyzer (Hewlett Packard GC-MS system) was done using
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104230


Feb 28, 2018Open    AccessArticle

Ciprofloxacin Hydrochloride Encapsulated into PLGA Nanoparticles for Drug Delivery Application: Fractional Factorial Design

Tajudeen Adebileje, Sikiru Adebileje, P. O. Aye
Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and Nano-carriers of therapeutic agents for drug delivery applications. However, encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs) necessitates a defined step to understand the effects and interactions of parameters involved in production process. In pharmaceutics formulations, compared to
...
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104294


Jul 26, 2016Open    AccessArticle

Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety

Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash
The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been
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Open Access Library J. Vol.3, 2016
Doi:10.4236/oalib.1102876


Mar 31, 2016Open    AccessArticle

The Uses of Cyclopentanone for the Synthesis of Biologically Active Pyran, Pyridine and Thiophene Derivatives

Eman M. Samir
In the recent work, a series of novel pyran and pyridine and thiophene derivatives were designed and synthesized starting from 2-benzylidenecyclopentanone. The reactivity of these derivatives towards different chemical reagent was studied. The antitumor evaluations of the newly synthesized products were measured and the results showed that some of the synthesized products showed high cytotoxicity.
Open Access Library J. Vol.3, 2016
Doi:10.4236/oalib.1102532


Sep 22, 2015Open    AccessArticle

Comparison between Modeling of Cetirizine Solubility Using Different Approaches: Semi-Empirical Density Based Correlations vs. Peng-Robinson EoS

Mostafa Lashkarbolooki, Ali Zeinolabedini Hezave
The tunable nature of the solubility of various compounds, including molecules of pharmaceutical and biological interest, in supercritical fluids (SCFs) makes SCF extraction technology attractive for many separation and purification processes. Among the different influencing parameters, the most important one in the supercritical based processes is the knowledge of solubility of model solute. But, experimental measurement of the solubility of all pharmaceuticals in wide ranges of temperature and...
Open Access Library J. Vol.2, 2015
Doi:10.4236/oalib.1101715


Nov 26, 2014Open    AccessArticle

New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity

Rafat M. Mohareb, Sherif M. Sherif, Wagnat W. Wardakhan, Amr S. Abouzied
Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) a...
Open Access Library J. Vol.1, 2014
Doi:10.4236/oalib.1101089


Sep 10, 2014Open    AccessArticle

Simple UV Spectrophotometric Assay of Metronidazole

Safila Naveed, Fatima Qamar
Metronidazole is a derivative of benzimidazole. It is being used widely for the treatment of amoebiasis. An efficient, simple and least time consuming spectrophotometric method for the assay of metronidazole has been developed. Comparison of assay of three different brands of metroni-da- zole has also been available in public medical stores of Karachi, Pakistan. The assay is based on the ultraviolet UV absorbance maxima at about 340 nm wavelength of metronidazole using water as solvent. A sample...
Open Access Library J. Vol.1, 2014
Doi:10.4236/oalib.1100615


Aug 19, 2014Open    AccessArticle

Effect of Acid, Base and Time on Different Brands of Glimepiride

Safila Naveed, Hina Qamar, Wardha Jawaid, Urooj Bokhari

The objective of this study is to develop the degradation studies of different brands of glimepiride available in market. Forced degradation is a powerful tool used routinely in pharmaceutical development in order to develop stability-indicating methods that lead to quality stability data and to understand the degradation pathways of the drug substances and drugs. Glimepiride is a medium- to long-acting sulfonylurea antidiabetic drug as it is the most prescribed oral antih

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Open Access Library J. Vol.1, 2014
Doi:10.4236/oalib.1100744


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