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Jun 11, 2020Open Access
The study investigated the protective and curative effects of unripe palm kernel seeds on monosodium glutamate-induced uterine fibroid in rats. The rats were in eight experimental groups according to the time of administration of the unripe palm kernel seeds: the first four groups investigated protective effects of UPK for 28 days and the last four groups investigated the curative effects of UPK after treatment with MSG for 28 days. MSG was administered to the animals by oral gavage at a dose of...
May 08, 2020Open Access
Rosa damascena or Damask rose is an aromatic shrub-like plant which has been originated from Damascus region. This flower has been used in traditional medicine and traditional cuisine for centuries. Different extracts have been prepared from its flowers as essential oils, rose water or jams. Very recently, UNESCO has inscribed the element of the Damascus rose or Rosa damascena and associated heritage practices and craftsmanship on the UNESCO Intangible Cultural Heritage of Humanity list for its ...
Mar 05, 2018Open Access
The bioactive compounds in
methanol extract of Xylopia aethiopica fruits were determined using a combination of gas chromatography and mass
spectrometry (GC-MS). The compound identification was based on the molecular
structure, molecular mass and calculated fragments. Interpretation on mass
spectrum of GC-MS analyzer (Hewlett Packard GC-MS system) was done using ...
Feb 28, 2018Open Access
Over several decades, poly
(lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and
Nano-carriers of therapeutic agents for drug delivery applications. However,
encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs)
necessitates a defined step to understand the effects and interactions of
parameters involved in production process. In pharmaceutics formulations, compared
to ...
Jul 26, 2016Open Access
The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been ...
Mar 31, 2016Open Access
In the recent work, a series of novel pyran and pyridine and thiophene
derivatives were designed and synthesized starting from 2-benzylidenecyclopentanone. The reactivity of these derivatives
towards different chemical reagent was studied. The antitumor evaluations of
the newly synthesized products were measured and the results showed that some
of the synthesized products showed high cytotoxicity.
Sep 22, 2015Open Access
The tunable nature of the solubility of various compounds, including
molecules of pharmaceutical and biological interest, in supercritical fluids
(SCFs) makes SCF extraction technology attractive for many separation and purification
processes. Among the different influencing parameters, the most important one
in the supercritical based processes is the knowledge of solubility of model
solute. But, experimental measurement of the solubility of all pharmaceuticals
in wide ranges of temperature and...
Nov 26, 2014Open Access
Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or
ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f.
The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3- b]pyridine, thieno[2,3- c]pyrimidine and coumarin derivatives
was studied. The anti-tumor evaluation of the newly synthesized compounds
against the three human tumor cells lines namely breast adenocarcinoma (MCF-7),
non-small cell lung cancer (NCI-H460) a...
Sep 10, 2014Open Access
Metronidazole is a derivative of benzimidazole. It
is being used widely for the treatment of amoebiasis. An efficient, simple and
least time consuming spectrophotometric method for the assay of metronidazole
has been developed. Comparison of assay of three different brands of metroni-da- zole has also been available in public medical stores of Karachi, Pakistan. The assay is based on
the ultraviolet UV absorbance maxima at about 340 nm wavelength of
metronidazole using water as solvent. A sample...
Aug 19, 2014Open Access
The
objective of this study is to develop the degradation studies of different
brands of glimepiride available in market. Forced degradation is a powerful
tool used routinely in pharmaceutical development in order to develop stability-indicating
methods that lead to quality stability data and to understand the degradation pathways of the drug substances and drugs.
Glimepiride is a medium- to long-acting sulfonylurea antidiabetic drug
as it is the most prescribed oral antih ...
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