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Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety

DOI: 10.4236/oalib.1102876, PP. 1-7

Subject Areas: Organic Chemistry, Medicinal Chemistry

Keywords: Synthesis, Thieno[2,3-d]Pyrimidine, Thiosemicarbazides, Anticancer Agents

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Abstract

The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been elucidated on the basis of elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR and MS). The in vitro cytotoxic activity of the synthesized derivatives was evaluated against two human cell lines: prostate cancer (PC-3) and colon cancer (HCT-116).

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Salib, S. B. , Khalil, O. M. , Kamel, M. M. and El-Dash, Y. (2016). Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety. Open Access Library Journal, 3, e2876. doi: http://dx.doi.org/10.4236/oalib.1102876.

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