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Feb 26, 2021Open    AccessArticle

Boxing Match Decisions as Influenced by the Practitioner Body Weight

André Mukala Nsengu Tshibangu
In 99 of the top 100 male professional boxers enrolled in the present study, weight division midpoints are linked by 1) an average strength correlation with the number of non-knockout wins; 2) weak correlations with the number of all wins pooled together, the number of knockout wins as well as with the number of draws; and 3) strong correlations with the number of all losses pooled together, the number of knockout losses, as well as the number of non-knockout losses. Wins arithmetic mean values ...
Open Access Library J. Vol.8, 2021
Doi:10.4236/oalib.1107159


Jul 08, 2020Open    AccessArticle

Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19

Gao-De Li
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106536


May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106340


Jan 14, 2020Open    AccessArticle

ROS-Dependent Cell Death Induced by Parthenolide in Human Hepatoma Cell HepG2

Weihua Xu, Keli Ge, Yunliang Guo, Wenhao Zhu, Liping Liu, Yonghong Zhou
With the increase of the action time and dosing concentration, the proliferation of HepG2 cell was inhibited and its vitality gradually decreased. FCM showed that, with the increase of PN action time, the MMP gradually decreased; calcium ions flowed inwards; the cell cycle was arrested in phase G1; the cell apoptosis rate, especially late apoptosis and necrotic cells, increased. The shear expression of apoptosis-related proteins c
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Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106025


Jun 28, 2019Open    AccessArticle

Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure

Gao-De Li
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin configuration is associated with cell potency and has an advantage over inflexible one in regulating genome related activities, such as DNA replication, DNA tra
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105531


Feb 28, 2019Open    AccessArticle

Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis

Gao-De Li
More than 30 years ago, we published a hypothesis in which the 3-dimen- sional structure of entire chromatin fibres in a eukaryotic cell is named as chromatin configuration that determines the pattern of gene expression in each type of cell. Based on this hypothesis, cell differentiation is the process in which different types of cells are endowed with different chromatin configura-tions. Therefore, this chrom
...
Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105246


Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.
...
Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105185


Oct 31, 2018Open    AccessArticle

Mendel Actually Wants to Say: Genes Are Only One Element of the Hereditary Material

Muying Zhou
The individual comes from a fertilized egg, indicating that the individual’s producer, namely the hereditary material, must be in the egg. “Modern genetics” includes the belief that genes are the hereditary material. Thus, the claim that “synthetic life” was created using a man-made genome has been made. However, molecular biology has proven that genes are only templates for individuals. The template has the controlling product’s
...
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104941


Jun 07, 2018Open    AccessArticle

The Law of Self-Replication and the Birth of Life Science

Muying Zhou
The understanding of the unique replication facts of living things helps us to discover the basic law of the life world: the law of self-replication. This law re-veals the root causes of life arising and lays the foundation stone for life sci-ence. From now on, what is a living thing, what does life mean? There has been a standard (the definition).
Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104644


May 29, 2018Open    AccessArticle

The Answer to the “First Question” in Genetics: The Hereditary Material

Muying Zhou
The basis of genetics should be the hereditary material which should be able to produce the individual. DNA (Genes) is ever regarded as the producer of the individual. However, DNA being lack of producing force can not produce the individual. So, this paper’s task is to look for another element, producing force, which along with genes (DNA) forms the hereditary material. And finally the paper
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104645


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