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Jan 08, 2025Open Access
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...
Jul 26, 2024Open Access
Fucoxanthin, a compound with anti-cancer, antioxidant, anti-diabetic, and anti-obesity properties, can be produced in Isochrysis zhanjiangensis, a microalga. A key rate-limiting enzyme in MEP pathway for fucoxanthin biosynthesis is 1-deoxy-D-xylulose-5-phosphate synthase (IzDXS). This study aims to investigate the characteristics of IzDXS gene and protein and provide methods to enhance fucoxanthin yield considering its wide potential applications. Bioinformatic analysis, phylogenic analysis, and...
Jun 28, 2024Open Access
Introduction: The last few decades have seen considerable progress in the diagnosis and medical management of infectious diseases. Among these diseases, urogenital infections caused by Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae and Streptococcus spp. remain a major cause of morbidity and mortality in Ouagadougou (Burkina Faso). The aim of this study was to evaluate the performance of the Bac Multi-Screen-Real- TMkit com...
May 10, 2024Open Access
Citrobacter are Gram-negative bacteria that give public health challenges due to their zoonotic infections. Diarrheal diseases and antimicrobial resistance are global concerns that increase the burden of implementing infectious disease monitoring, especially in poor economic countries. This study was conducted to determine the prevalence and antimicrobial susceptibility and assess the risk factors of diarrheal diseases caused by bacteria from drinking water wells in the Urban West Regio...
Jun 28, 2023Open Access
We performed aurora kinase gene expression analysis, in combination with FISH and micronucleus test, in buccal mucosa cells isolated from agricultural workers to better understand the dynamics of genomic instability in these groups of professionals. Two out of a total of 97 agricultural workers who consented to participate in the study (39 men and 58 women) reported a history of cancer based on a previously applied questionnaire. The participants were 28.4 years on average and were categorized i...
Apr 28, 2023Open Access
The transcription factors of the bZIP (basic leucine zipper) family are involved in the regulation of molecular analysis in fruit development, plant architecture, and response to environmental factors. Here, we performed transcription of the SlbZIP39 gene in various tissues and fruit developmental stages. However, they revealed that the different transcription levels of tomato tissues were expressed by floral parts and immature green stages. We observed that SlbZIP39 was ind...
Aug 20, 2021Open Access
The network pharmacology and molecular docking technology were used to elucidate the mechanism of Artemisiae scopariae Herba (ASH) against liver cancer (LC). TCMSP and UniProt database were used to collect the active ingredients of ASH and predict their potential targets. The targets of LC were screened by GeneCards, OMIM and TTD database. The intersections of drug and disease targets were obtained by online software Venny 2.1, and the intersection targets were imported into R software (v3.6.3) ...
May 07, 2021Open Access
The hallmarks of cancer are determined by cancer-associated gene expression pattern that is determined by cancer-associated chromatin configuration (CACC). Using non-carcinogenic genotoxic drugs (NCGDs) to alter CACC could change cancer-associated gene expression pattern, which in turn, might cause disappearance of some or whole hallmarks of cancer and as a result, cancer cells could be killed by either apoptosis or immune destruction. Therefore, cancer could be prevented and treated by administ...
Feb 26, 2021Open Access
In 99 of the top 100 male professional boxers enrolled in the present study, weight division midpoints are linked by 1) an average strength correlation with the number of non-knockout wins; 2) weak correlations with the number of all wins pooled together, the number of knockout wins as well as with the number of draws; and 3) strong correlations with the number of all losses pooled together, the number of knockout losses, as well as the number of non-knockout losses. Wins arithmetic mean values ...
Jul 08, 2020Open Access
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
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