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Feb 26, 2021Open AccessArticle
In 99 of the top 100 male professional boxers enrolled in the present study, weight division midpoints are linked by 1) an average strength correlation with the number of non-knockout wins; 2) weak correlations with the number of all wins pooled together, the number of knockout wins as well as with the number of draws; and 3) strong correlations with the number of all losses pooled together, the number of knockout losses, as well as the number of non-knockout losses. Wins arithmetic mean values ...
Jul 08, 2020Open AccessArticle
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
May 15, 2020Open AccessArticle
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Jan 14, 2020Open AccessArticle
With the increase of the action time and dosing concentration, the proliferation of HepG2 cell was inhibited and its vitality gradually decreased. FCM showed that, with the increase of PN action time, the MMP gradually decreased; calcium ions flowed inwards; the cell cycle was arrested in phase G1; the cell apoptosis rate, especially late apoptosis and necrotic cells, increased. The shear expression of apoptosis-related proteins c ...
Jun 28, 2019Open AccessArticle
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin configuration is associated with cell potency and has an advantage over inflexible one in regulating genome related activities, such as DNA replication, DNA tra ...
Feb 28, 2019Open AccessArticle
More than 30 years ago, we published a hypothesis in which the 3-dimen- sional structure of entire chromatin fibres in a eukaryotic cell is named as chromatin configuration that determines the pattern of gene expression in each type of cell. Based on this hypothesis, cell differentiation is the process in which different types of cells are endowed with different chromatin configura-tions. Therefore, this chrom ...
Feb 01, 2019Open AccessArticle
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented. ...
Oct 31, 2018Open AccessArticle
The individual comes from a fertilized egg, indicating that the individual’s producer, namely the hereditary material, must be in the egg. “Modern genetics” includes the belief that genes are the hereditary material. Thus, the claim that “synthetic life” was created using a man-made genome has been made. However, molecular biology has proven that genes are only templates for individuals. The template has the controlling product’s ...
Jun 07, 2018Open AccessArticle
The understanding of the unique replication facts of living things helps us to discover the basic law of the life world: the law of self-replication. This law re-veals the root causes of life arising and lays the foundation stone for life sci-ence. From now on, what is a living thing, what does life mean? There has been a standard (the definition).
May 29, 2018Open AccessArticle
The basis of genetics
should be the hereditary material which should be able to produce the
individual. DNA (Genes) is ever regarded as the producer of the individual. However,
DNA being lack of producing force can not produce the individual. So, this
paper’s task is to look for another element, producing force, which along with
genes (DNA) forms the hereditary material. And finally the paper ...
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