Objective: The aim of the present study is to assess the role of the level of change in gene expression of the HOTAIR molecule in breast cancer patients. Methods: An assay was conducted for the level of gene expression of the HOTAIR molecule in the plasma of 30 patients and 10 healthy controls, by performing the reverse transcription reaction RT-qPCR, gene expression was evaluated using the Livak equation, tumor characteristics (grade, HER2 receptors, hormonal (...

Cell Biology  Oncology  Biochemistry 

Background: Glioblastoma is the most prevalent and aggressive primary malignant brain tumor, known for its rapid growth and local invasion. While it predominantly remains within the central nervous system, extracranial metastasis is extremely rare, involving the liver, lymph nodes, thorax, spleen, and bones. Thoracic involvement is often associated with the worst prognosis. Aim: This paper presents a unique case of lung metastasis from glioblastoma, highlighting...

Neurology  Oncology  Surgery & Surgical Specialties 

Background: Renal metastases from non-small cell lung cancer (NSCLC) are rare, treatment guidelines for renal metastases from NSCLC are unclear, mostly based on clinical case reports. Data on the effectiveness of osimertinib in the group of patients with renal metastatic NSCLC who have epidermal growth factor receptor (EGFR) mutations del19 or L858R is still incomplete. Purpose: In this study, we report a case of the bilateral renal metastatic NSCLC who was treated by the first...

Oncology 

Background: Cerebellopontine (CP) angle in adults may harbor a number of tumors. The most common tumors in this location include schwannoma, meningioma, and epidermoid tumor followed by metastatic lesions. Cerebellopontine angle (CPA) is an atypical site for adult medulloblastoma (MB) with only 13 cases reported in pure extra-axial location. Cases Présentations: We report a case of 22-year-old male, both presented with headache, vomiting, ataxia Magnetic resonan...

Neurology  Oncology 

Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...

Neuroscience  Biological Materials  Pharmacology  Nanometer Materials  Drugs & Devices  Molecular Biology  Toxicology  Organic Polymer Materials  Medicinal Chemistry  Clinical Medicine  Bioengineering  Biotechnology  Biological Engineering  Cell Biology  Oncology  Synthetic Biology  Radiology & Medical Imaging  Diagnostics 

Objective: To assess the value of MRI in the diagnosis of brain metastases due to the main primary tumours in patients who have undergone MRI at the CNSS. Methods: This is a retrospective, descriptive study of 3 years and 7 months duration from January 2019 to July 2023 involving 24 cases. We included in our study, all records of patients whose brain MRI was interpreted as being in favour of brain metastases. The examinations were performed using a TOSHIBA (CANO...

Oncology 

Sarcomatoid carcinoma is a rare and aggressive tumor that can occur in various organs, including the stomach. We aim to present a case of metastatic gastric sarcomatoid carcinoma and highlight the challenges in its diagnosis and treatment. We report the case of a 72-year-old female patient with metastatic gastric sarcomatoid carcinoma. The patient presented with intractable nausea, vomiting, abdominal pain, and significant weight loss. Imaging studies revealed a large tumor in the antropyloric r...

Oncology 

Research background: The FAST FORWARD protocol is a hypo-fractionated treatment regimen for early breast cancer, generally involving fewer sessions with higher doses per fraction compared to traditional regimens. Application of DIBH minimize radiation exposure to the heart and lungs during treatment of left-sided breast cancer. Research objectives: The aim of the present study, was to compare the dosimetric goals properties of the restricted tangential Intensity...

Oncology 

This study compares logit and probit regression models to analyze the likelihood of lung cancer occurrence based on patient data and lifestyle factors. The results reveal significant associations between lung cancer and patients’ age, gender, smoking status, yellow finger, anxiety, chronic disease, fatigue, allergy, wheezing, alcohol consumption, coughing, shortness of breath, swallowing difficulty, and chest pain. The result shows that the probit model better predicts lung cancer based on the f...

Gastroenterology & Hepatology  Oncology 

We report the case of a mucinous colloid carcinoma of the breast. We managed a 63-year-old woman with a right retroareolar lesion, clinically classified as cT2 N0 M0 and radiologically suspicious. Histological analysis (biopsy) concluded it was a grade I mucinous colloid carcinoma of the breast according to the Scarff-Bloom-Richardson (SBR) grading system. Additional treatments included partial mastectomy, lymph node dissection, radiotherapy, and hormone therapy. Colloid carcinoma is rare, accou...

Oncology