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Jul 21, 2023Open    Access

Atopic Dermatitis Related to RNF31 Genetic Variant

César Daniel Alonso-Bello, Sonia del Carmen Chávez-Ocana, Carol Vivian Moncayo-Coello, María Isabel Rojo-Gutierrez
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110339


Apr 28, 2022Open    Access

Trends and Hotspots of microRNAs in Epilepsy: A 10-Year Cross-Sectional Study

Shenglin Wang, Guohui Jiang
miRNAs regulate a variety of target proteins and signaling pathways associated with epilepsy. We conducted a cross-sectional study of publications associated with microRNA in epilepsy in the past 10 years using bibliometric methods. Our results showed that the number of publications elevated gradually, peaking in 2020. Countries/institutions collaboration network showed that extensive international cooperation between countries existed and China published the most of papers in this field. USA, I...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108650


Mar 18, 2022Open    Access

Febuxostat: Successful Desensitization Protocol

Cesar Daniel Alonso-Bello, Mayra Matías-Carmona, Victoria Isabel Castaneda-ávila, Evelyn Aranda-Cano, María Isabel Castrejón-Vázquez
Hyperuricemia is defined as the increase in uric acid when it exceeds its solubility limit, about 6.8 mg/dl. Persistent hyperuricemia causes diseases such as gouty arthritis, arthropathy, urolithiasis, and nephropathy. We present the clinical case of a 46-year-old patient with gout and persistent hyperuricemia; he presented cutaneous hypersensitivity to allopurinol and febuxostat and, for this reason, the patient stopped the treatment. After undergoing a 5-day new febuxostat desensitization prot...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108481


Jun 04, 2021Open    Access

Aneurysmal Carotid Cavernous Fistula (ACCF), Management and Outcome: Case Report and Review of the Literature

Adil Belhachmi, Yao Christian Hugues Dokponou, Miloud Gazzaz
Carotid cavernous fistula is an abnormal communication between the cavernous portion of the carotid artery and the venous bed of cavernous sinus with secondary increased pressure in the cavernous sinus leading to clinical presentations depending on the vascular and/or nervous structures involved in this injury process. The patient may present in the emergency room with proptosis, cranial nerve palsy, increased intraocular pressure, diplopia, decreased vision, and sometimes blindness in case of a...
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107335


Jan 14, 2020Open    Access

Phenocopies: Mimics of Inborn Errors of Immunity

Cesar Daniel Alonso-Bello, Sara Elva Espinosa-Padilla, Mariano Daniel Temix-Delfin, Fernando Lozano-Patino, Victoria Isabel Castaneda-Avila, Maria Eugenia Vargas-Camano, María Isabel Castrejón-Vázquez
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are ca
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Open Access Library J.   Vol.7, 2020
Doi:10.4236/oalib.1106041


May 20, 2019Open    Access

Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians

García-López Carlos Alberto, Alcázar-Casarín Emmanuel, Ynga-Durand Mario Alberto, Alonso-Bello César Daniel, Lozano-Patino Fernando, Vargas-Camano María Eugenia, Espinosa-Padilla Sara Elva, González-Serrano Maria Edith, Castrejón-Vázquez María Isabel
Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in or
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Open Access Library J.   Vol.6, 2019
Doi:10.4236/oalib.1105419


Aug 15, 2017Open    Access

Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

Melati Sudiro, Bony Wiem Lestari, Teti Madiadipoera, Budi Setiabudiawan, Thaufiq Siddiq Boesoirie
Background: Vitamin D deficiency has been targeted as a cause of the increased incidence of allergic rhinitis. Many factors, including sun exposure, influence vitamin D levels. Indonesia is a country with abundant sunshine exposure throughout the year; therefore, Indonesian residents are not expected to have inadequate vitamin D levels. Objective: This study aimed to investigate whether vitamin D deficiency
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Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1103813


Jun 09, 2017Open    Access

Severe Allergic Reaction to Oral Artesunate-Amodiaquine Combination Treatment for Malaria: Case Report in the Democratic Republic of Congo

Edouard Kawawa Swana, Christian Katshiza, Oscar Numbi Luboya, Michael J. Bangs
Background: In 2012-2013, a pilot study on implementation of community-based case malaria management by trained community health workers was implemented in southern Katanga Province in the Democratic Republic of Congo (DRC). We report one case of severe adverse reaction that was linked to artesunate-amodiaquine (ASAQ). Case summary: An apparent healthy, 15-year-old Congolese female with a positive rapid diagnostic test for
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Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1103676


Mar 28, 2017Open    Access

Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General Hospital

Chaw Su Naing, Yong Yeow Chong
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed classes of drugs and are easily accessible as over-the-counter anti-inflammatory drugs in Singapore. NSAIDs hypersensitivity is the second most common referral to allergy clinic in a tertiary referral centre. Methods: Referred patients with history of NSAID intolerance were underwent open challenge with 1) putative NSAID to confirm the diagnosis
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Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1103435


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