All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

DOI: 10.4236/oalib.1103813, PP. 1-9

Subject Areas: Allergy & Clinical Immunology

Keywords: Allergic Rhinitis, Vitamin D Deficiency, Indonesia

Full-Text   Cite this paper   Add to My Lib


Background: Vitamin D deficiency has been targeted as a cause of the increased incidence of allergic rhinitis. Many factors, including sun exposure, influence vitamin D levels. Indonesia is a country with abundant sunshine exposure throughout the year; therefore, Indonesian residents are not expected to have inadequate vitamin D levels. Objective: This study aimed to investigate whether vitamin D deficiency levels are correlated with disease spectrum among allergic rhinitis patients. Material and Method: A cross-sectional study was conducted in the Rhino-Allergy ORL-HNS Clinic at Dr. Hasan Sadikin General Hospital in Bandung, Indonesia, from March-June 2016. All subjects underwent skin prick tests and serum 25-hydroxy vitamin D levels examination. To measure the association between vitamin D deficiency level and severity of allergic rhinitis, a Rank-Spearman correlation test was used and significant level was determined when the p-value is <0.05. Results: A total of 46 allergic rhinitis patients (19 males, 27 females, aged 28.3 ± 6 years) were included in this study. 63% of allergic rhinitis patients had a severe vitamin D deficiency and 50% of them classified as having persistent moderate-severe based on ARIA-WHO classification. Vitamin D deficiency was found to be significantly correlated with severity of allergic rhinitis status (rs = ?0.321; p = 0.005). Conclusion: We found vitamin D deficiency was correlated with allergic rhinitis classification and a significant proportion of allergic rhinitis patients showed a severe vitamin D deficiency.

Cite this paper

Sudiro, M. , Lestari, B. W. , Madiadipoera, T. , Setiabudiawan, B. and Boesoirie, T. S. (2017). Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis. Open Access Library Journal, 4, e3813. doi:


[1]  Bousquet, J., Khaltaev, N., Cruz, A.A., Denburg, J., Fokkens, W.J., Togias, A., et al. (2008) Allergic Rhinitis and Its Impact on Asthma (ARIA) 2008 Update (in Collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 63, 8-160.
[2]  Pawankar, R., Bunnag, C., Khaltaev, N. and Bousquet, J. (2012) Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008. World Allergy Organization Journal, 5, S212-S217.
[3]  Moeis, R.M., Sudiro, M. and Herdiningrat, S. (2014) Allergic Rhinitis Patient Charactheristics in dr Hasan Sadikin General Hospital Bandung Indonesia. Althea Medical Journal, 1, 75-80.
[4]  Pawankar, R., Mori, S., Ozu, C. and Kimura, S. (2011) Overview on the Pathomechanisms of Allergic Rhinitis. Asia Pacific Allergy, 1, 157-167.
[5]  Sin, B. and Togias, A. (2011) Pathophysiology of Allergic and Nonallergic Rhinitis. Proceedings of the American Thoracic Society, 8, 106-114.
[6]  Hewison, M. (2012) Vitamin D and Immune Function: An Overview. The Proceedings of the Nutrition Society, 71, 50-61.
[7]  Cantorna, M.T., Snyder, L., Lin, Y.D. and Yang, L. (2015) Vitamin D and 1,25(OH)2D Regulation of T Cells. Nutrients, 7, 3011-3021.
[8]  Hewison, M. (2011) Vitamin D and Innate and Adaptive Immunity. Vitamins and Hormones, 86, 23-62.
[9]  Mirzakhani, H., Al-Garawi, A., Weiss, S.T. and Litonjua, A.A. (2015) Vitamin D and the Development of Allergic Disease: How Important Is It? Clinical & Experimental Allergy, 45, 114-125.
[10]  Setiati, S. (2008) Vitamin D Status among Indonesian Elderly Women Living in Institutionalized Care Units. Acta Medica Indonesiana, 40, 78-83.
[11]  Bikle, D. (2000) Vitamin D: Production, Metabolism, and Mechanisms of Action. In: De Groot, L.J., Chrousos, G., Dungan, K., et al., Eds., Endotext,, Inc., South Dartmouth.
[12]  Puri, S., Marwaha, R.K., Agarwal, N., Tandon, N., Agarwal, R., Grewal, K., et al. (2008) Vitamin D Status of Apparently Healthy Schoolgirls from Two Different Socioeconomic Strata in Delhi: Relation to Nutrition and Lifestyle. British Journal of Nutrition, 99, 876-882.
[13]  Yenigun, A., Dadaci, Z. and Oncel, M. (2015) Plasma Vitamin D Levels of Patients with Allergic Rhino-Conjunctivitis with Positive Skin Prick Test. The American Journal of Rhinology & Allergy, 29, e46-e49.
[14]  Vatankhah, V., Lotfizadeh, M., Iranpoor, H., Jafari, F. and Khazraei, H. (2016) Comparison Vitamin D Serum Levels in Allergic Rhinitis Patients with Normal Population. Revue Francaise d’Allergologie, 56, 539-543.
[15]  Kalayci, O., Yorgancioglu, A., Kalyoncu, F., Khaltaev, A.N. and Bousquet, J. (2008) Allergic Rhinitis and Its Impact on Asthma Update (ARIA 2008): The Turkish Perspective. The Turkish Journal of Pediatrics, 50, 307-312.
[16]  Modh, D., Katarkar, A., Thakkar, B., Jain, A., Shah, P. and Joshi, K. (2014) Role of Vitamin D Supplementation in Allergic Rhinitis. Indian Journal of Allergy, Asthma and Immunology, 28, 580-590.
[17]  Kim, Y.H., Kim, K.W., Kim, M.J., Sol, I.S., Yoon, S.H., Ahn, H.S., et al. (2016) Vitamin D Levels in Allergic Rhinitis: A Systematic Review and Meta-Analysis. Pediatric Allergy and Immunology, 27, 580-590.
[18]  Tham, E.H., Lee, A.J. and Bever, H.V. (2016) Aeroallergen Sensitization and Allergic Disease Phenotypes in Asia. Asian Pacific Journal of Allergy and Immunology, 34, 181-189.
[19]  Bikle, D.D. (2014) Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. Chemistry & Biology, 21, 319-329.
[20]  Oren, E., Banerji, A. and Camargo, C.A. (2008) Vitamin D and Atopic Disorders in an Obese Population Screened for Vitamin D Deficiency. Journal of Allergy and Clinical Immunology, 121, 533-534.
[21]  Wjst, M. and Hypponen, E. (2007) Vitamin D Serum Levels and Allergic Rhinitis. Allergy, 62, 1085-1086.


comments powered by Disqus

Contact Us


WhatsApp +8615387084133

WeChat 1538708413