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Aug 29, 2023Open Access
Impurities, particularly those associated with the API (active pharmaceutical ingredient) and causing deterioration or interaction, may lower a drug’s quality, safety, and efficacy. The successful reduction and control of impurities in pharmaceuticals rely on safety-based impurity limits. Many methods have been developed to define a practically safe dosage of impurities, with an emphasis on daily exposure limitations. They include permissible daily exposure (PDE), acceptable intake (AI), the thr...
Aug 22, 2023Open Access
The use of fruits both domestically and industrially generates waste from their discarded peels which may lead to environmental pollution and contamination. This work aims at evaluating the effects of chemical pre-treatment of biomass on the physicochemical properties and the effects of process parameters on the production of ethanol via solid-state fermentation. The biomass was dried, ground and subjected to chemical pretreatment using H 2SO 4 and NaOH. pH, total Titratable ...
Jul 21, 2022Open Access
Legumes have played an important role in traditional diets in various regions of the world because they meet the recommended dietary guidelines for healthy eating. The present study aimed to determine and evaluate the mineral composition of legumes consumed in the municipality of Vitória da Conquista-BA using optical emission spectrometry with inductively coupled plasma. Minerals, calcium, magnesium, potassium, iron, manganese and zinc were determined in samples of chickpeas, soybeans, peas and ...
May 16, 2022Open Access
Due to the potential threats of nitrite to public health and safety, in this work, we proposed, for the first time, the application of PhotoMetrix ® software for the detection of nitrite in meat products. Nitrite monitoring in food matrices has been carried out by expensive analytical methods. Aiming mainly speed and cost reduction, colorimetric analysis software has been developed using digital imaging. Among them, the PhotoMetrix ®, a free software based on template...
Apr 12, 2022Open Access
Aloe barbadensis Miller ( A. barbadensis) has been reported for use in the traditional management of malaria in Kenya. Aloin (an anthraquinone-C-gly-coside) is one of the therapeutic molecules in Aloe species that is responsible for their antimalarial effect. However, there is no report on the aloin content of A. barbadensis leaves latex and gel from Kenya. This study, therefore, isolated and quantified aloin levels in Phosphate Buffered Saline (PBS) extracts of A. ...
Mar 21, 2022Open Access
Pesticide residues cause different health hazards when they are present in primary as well as secondary agricultural products. In this manuscript, an analytical method was developed and validated for the assessment of pesticide residues present in various vegetables and fruits most commonly consumed in Pakistan. Seven samples of various fresh fruits and vegetables were processed and analyzed for the detection and identification of different pesticides by using the quick easy cheap effective rugg...
Jan 26, 2022Open Access
Physicochemical analysis and fatty acid content of chemical and traditional extracted shea kernel ( Vitellaria paradoxa) from Kwara State Nigeria have been studied. The extraction of shea butter from shea kernel using chemical and traditional techniques as well as its physicochemical analysis reveals that both the chemical extracted shea butter (CSB) and the traditional extracted shea butter (TSB) are very similar in properties save for the odor (slightly choking nutty odor for CSB and sli...
Dec 16, 2021Open Access
Competitive adsorption of Fe 2 , Ni 2 , Pb 2 , Cu 2 and Zn 2 in a multi-element solution was compared with the adsorption of the same in individual element solutions using cation exchange resins developed from modified peanut testa extract (PTE) as adsorbents. Modified PTE-polyphenols cation exchangers were prepared by first crosslinking with phosphorus oxychloride (POCl3) before functionalizing with chlorosulphonic acid (CSA). In another insta...
Oct 09, 2021Open Access
Based on the principle that DNA ligation reaction mediates hydrolysis of the dumbbell probe (DP), a novel label-free strategy for sensitive detection of DNA ligase was developed. DNA ligase ligated the nick on DP to generate a fully closed dumbbell DNA structure, which could prevent the hydrolysis of exonuclease, after combining with SYBR Green I (SG I), a strong fluorescent signal was obtained. In the absence of DNA ligase, DP was hydrolyzed into single nucleotides by exonuclease, resulting in ...
Aug 05, 2021Open Access
The proton transfer reaction of Ethyl 3,5-dinitrosalicylate, ethyl ester of 3,5-dinitrosalicylic acid (DNS), and ethylenediamine has been investigated. The reaction stoichiometry was 1:1 giving a molecular salt namely 2-Ami- noethanaminium 2-(ethoxycarbonyl)-4,6-dinitrophenolate (AED). The single crystals were grown by the slow solvent evaporation technique using DMF- water as a solvent at room temperature and found in a dimeric form. The structure was confirmed by single crystal X-ray diffracti...
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