OALib Journal
  OALib Journal is an all-in-one open access journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721). It accepts a manuscript for the peer-review processing, typesetting, publication and then allocated to one of the 322 subject areas. The article processing charge for publishing in OALib journal is Only $99. For more details, please contact service@oalib.com. Submit now
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Dec 23, 2022Open    AccessArticle

The Role of Autophagy in Acute Myeloid Leukemia

Siyu Zhou, Yu Wu, Yili Cai, Zecheng Yu, Ruirui Li, Chunwei Yan, Fangwei Dai, Wei Han
Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a po...
Open Access Library J.   Vol.9, 2022

Aug 25, 2021Open    AccessArticle

Telomere Length Inheritance throughout Generations: Role of Germ Cell Mortality

Alyaa Rakha
Telomere is a structure of the repetitive DNA sequence TTAGGG and protein complex, found in vertebrates. This protein complex is known as the shelterin complex. It is localized at the end of each chromosome to protect them from deterioration or fusion with other chromosomes. Although as being part of a chromosome, the telomere is inherited from parents to their offspring, its mode of inheritance is a crucial part of the genetic transmission process. Theoretically, germ cells are thought to be im...
Open Access Library J.   Vol.8, 2021

May 07, 2021Open    AccessArticle

A Novel Strategy for Preventing and Treating Cancer: Alteration of Cancer-Associated Chromatin Configuration

Gao-De Li
The hallmarks of cancer are determined by cancer-associated gene expression pattern that is determined by cancer-associated chromatin configuration (CACC). Using non-carcinogenic genotoxic drugs (NCGDs) to alter CACC could change cancer-associated gene expression pattern, which in turn, might cause disappearance of some or whole hallmarks of cancer and as a result, cancer cells could be killed by either apoptosis or immune destruction. Therefore, cancer could be prevented and treated by administ...
Open Access Library J.   Vol.8, 2021

Feb 26, 2021Open    AccessArticle

Natural Killer Cell-Based Immunotherapy against Solid Cancer

Pinlei Lv, Wenrui Li, Ruoyu Wang, Guojun Huang, Yi Zhu, Qiqiang Tao
As a kind of important innate lymphocytes in vivo, Natural killer (NK) cells have a rapid and efficient capacity to recognize and destroy tumor cells, senescent cells and virus-infected cells. In the past decades, NK cells have been widely applied in the treatment of hematological malignancies in clinic, even solid tumors. Successful results have been made against hematological malignancies (NCT00697671, NCT00990717, NCT00145626), but also a number of considerable challenges have been encountere...
Open Access Library J.   Vol.8, 2021

Jul 08, 2020Open    AccessArticle

Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19

Gao-De Li
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
Open Access Library J.   Vol.7, 2020

May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Open Access Library J.   Vol.7, 2020

Mar 11, 2020Open    AccessArticle

Neonatal Screening for Lubumbashi Drepacytosis: Feasibility and Suitable Performance

Tina Katamea, Criss Koba Mjumbe, Maguy Ngongo Omoy, Dieudonné Bafwafwa, Matthieu Ngombe, Lydie Kasongo, Gautier Mutoba, Dieudonné Ngwej Tshikwej, Amir Assumani N’Simbo, Oscar Luboya Numbi, Léon Tshilolo, Sanislas Wembonyama
Sickle cell anemia is a blood disorder linked to an abnormality in the structure of hemoglobin. The objective of this study was to determine the frequency of the sickle cell gene on the basis of early detection of hemoglobin using the isoelectric focusing technique in maternities in Lubumbashi. Our descriptive cross-sectional study consisted of newborns and infants up to 6 months of age. The capillary venous blood was collected on the finger for the rapid and direct test and on blotting paper fo...
Open Access Library J.   Vol.7, 2020

Jan 20, 2020Open    AccessArticle

Bromatological Analysis and Antioxidant Capacity of Hibiscus sabdariffa L. in Cuba

Francis Brown, José González, Enrique C. Cejas, Max Monan, Iván S. Sayago
Towards authentication and quality assurance of medicinal plants, calyces of Hibiscus sabdariffa L. recollected from the Experimental Station of Medicinal Plants “Dr Juan Tomas Roig” between January and April 2016 were analyzed to determine its bromatological properties (moisture content; dry matter; fat; protein; total ash; mineral contents) and its antioxidant
Open Access Library J.   Vol.7, 2020

Jun 28, 2019Open    AccessArticle

Hypothesis on Remote Memory Forming from Heterosynaptic LTD-Mediated Neuronal Degeneration

Zi-Jian Cai
In this article, it is hypothesized a new mechanism for the formation of stable remote memory in brain comprising the important memory acquired during childhood and the common words in language. It has been demonstrated that the memory forms concurrently at both homosynaptic long term potentiation (LTP) and heterosynaptic long term depression (LTD). It is pointed out that the repeated LTD may result in neuronal degeneration as evi
Open Access Library J.   Vol.6, 2019

Jun 28, 2019Open    AccessArticle

Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure

Gao-De Li
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin configuration is associated with cell potency and has an advantage over inflexible one in regulating genome related activities, such as DNA replication, DNA tra
Open Access Library J.   Vol.6, 2019


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