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May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106340


Jun 28, 2019Open    AccessArticle

Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure

Gao-De Li
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin configuration is associated with cell potency and has an advantage over inflexible one in regulating genome related activities, such as DNA replication, DNA tra
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105531


Feb 28, 2019Open    AccessArticle

Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis

Gao-De Li
More than 30 years ago, we published a hypothesis in which the 3-dimen- sional structure of entire chromatin fibres in a eukaryotic cell is named as chromatin configuration that determines the pattern of gene expression in each type of cell. Based on this hypothesis, cell differentiation is the process in which different types of cells are endowed with different chromatin configura-tions. Therefore, this chrom
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105246


Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105185


Feb 09, 2017Open    AccessArticle

Methods for Non-Destructively Separating or Reannealing the Strands of Circular Duplex DNA Chromosomes

Ken Biegeleisen
Although it is not widely-known, the strands of circular duplex plasmid and viral chromosomes have been non-destructively separated, and the separated strands have been reconstituted to yield a new duplex structure with all the properties of the native chromosome restored. This suggests a paranemic structure for the DNA, that is, a structure whose strands are no
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Open Access Library J. Vol.4, 2017
Doi:10.4236/oalib.1103353


Jul 26, 2016Open    AccessArticle

Targeted Mutagenesis of Beta-Lactoglobulin Gene in Caprine Fetal Fibroblasts by Context-Dependent Assembly Zinc-Finger Nucleases

Yuguo Yuan, Yong Cheng, Jinyu Wang, Qiuling Peng
Targeted mutagenesis by zinc-finger nucleases (ZFNs) can be used to generate knock-out mammalian cell lines with high efficiency. A number of different methods have been developed for the design and assembly of gene-specific ZFNs, making them easily accessible to researchers. In this study, we used ZFNs assembled through the CoDA (context-dependent assembly) platforms to generate mutant caprine fetal fibroblasts cells for the BLG
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Open Access Library J. Vol.3, 2016
Doi:10.4236/oalib.1102813


Sep 10, 2014Open    AccessArticle

Opportunities, Constraints and Future Implication of Biotechnology in Animlal Feed Improvement

Bimrew Asmare
The major cause of poor livestock productivity in tropical regions of the world is inadequate nutrition. The shortage of feed in most developing countries and the increasing cost of feed constituents entail that there is a call for to improvement feed utilization strategies in developing countries. Animal feeds and feeding practices can be enhanced by biotechnology to develop better animal nutrition packages in smallholder and commercial production systems as well as to reduce environmental wast...
Open Access Library J. Vol.1, 2014
Doi:10.4236/oalib.1100493


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