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Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis

DOI: 10.4236/oalib.1105246, PP. 1-6

Subject Areas: Cell Biology, Genomics, Molecular Biology

Keywords: Cell-Type-Associated Chromatin Configuration, 3-Dimensional Genome Ar-chitecture, Cell Differentiation, Gene Regulation, Rivet Protein, Plasmodium falciparum Chloroquine Resistance Marker Protein (Pfcrmp)

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Abstract

More than 30 years ago, we published a hypothesis in which the 3-dimen- sional structure of entire chromatin fibres in a eukaryotic cell is named as chromatin configuration that determines the pattern of gene expression in each type of cell. Based on this hypothesis, cell differentiation is the process in which different types of cells are endowed with different chromatin configura-tions. Therefore, this chromatin configuration could also be named as cell-type-associated chromatin configuration. However, how this cell-type- as-sociated chromatin configuration is formed during cell differentiation remains unknown. In this paper, we hypothesize that a group of unknown proteins might be involved in the formation of cell-type-associated chromatin configu-rations during cell differentiation.

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Li, G. (2019). Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis. Open Access Library Journal, 6, e5246. doi: http://dx.doi.org/10.4236/oalib.1105246.

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