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Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

DOI: 10.4236/oalib.1105185, PP. 1-5

Subject Areas: Cell Biology, Molecular Biology, Developmental Biology, Genomics

Keywords: Chromatin Configuration, Oncogenesis, 3D Genome, Cancer, Cell Differentiation, Cell Cycle, Gene Regulation, Gene Activity

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More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.

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Li, G. (2019). Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis. Open Access Library Journal, 6, e5185. doi:


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