All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99

ViewsDownloads

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

DOI: 10.4236/oalib.1106340, PP. 1-9

Subject Areas: Pharmacology, Genomics, Molecular Biology, Cell Biology

Keywords: Chloroquine, Hydroxychloroquine, Anticancer, Antivirus, SARS-CoV-2, Coronavirus Disease 2019 (COVID-19), Immunomodulatory Effects, Three-Dimensional Genome Architecture, Plasmodium falciparum Chloroquine-Resistance Marker Protein (Pfcrmp), Genome Architectural Protein

Full-Text   Cite this paper   Add to My Lib

Abstract

Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hypothesis, new approaches to the treatment and prevention of cancer and coronavirus disease 2019 (COVID-19) are proposed.

Cite this paper

Li, G. (2020). Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions. Open Access Library Journal, 7, e6340. doi: http://dx.doi.org/10.4236/oalib.1106340.

References

[1]  Packard, R.M. (2014) The Origins of Antimalarial-Drug Resistance. New England Journal of Medicine, 371, 397-399. https://doi.org/10.1056/NEJMp1403340
[2]  Gao, J., Tian, Z. and Yang, X. (2020) Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy in Treatment of COVID-19 Associated Pneumonia in Clinical Studies. BioScience Trends, 14, 72-73. https://doi.org/10.5582/bst.2020.01047
[3]  Gautret. P., Lagier, J.C., Parola, P., Hoang, V.T., Meddeb, L., Mailhe, M. and Doudier, B., et al. (2020) Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-Label Non-Randomized Clinical Trial. The International Journal of Antimicrobial Agents, 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949
[4]  Antony, H.A. and Parija, S.C. (2016) Antimalarial Drug Resistance: An Overview. Tropical Parasitology, 6, 30-41. https://doi.org/10.4103/2229-5070.175081
[5]  Manic, G., Obrist, F., Kroemer, G., Vitale, I. and Galluzzi, L. (2014) Chloroquine and Hydroxychloroquine for Cancer Therapy. Molecular & Cellular Oncology, 1, e29911. https://doi.org/10.4161/mco.29911
[6]  Plantone, D. and Koudriavtseva, T. (2018) Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review. Clinical Drug Investigation, 38, 653-671. https://doi.org/10.1007/s40261-018-0656-y
[7]  Duffy. A., Le, J., Sausville, E. and Emadi, A. (2015) Autophagy Modulation: A Target for Cancer Treatment Development. Cancer Chemotherapy and Pharmacology, 75, 439-447. https://doi.org/10.1007/s00280-014-2637-z
[8]  Li, G.D. (2006) Nucleus May Be the Key Site of Chloroquine Antimalarial Action and Resistance Development. Medical Hypotheses, 67, 323-326. https://doi.org/10.1016/j.mehy.2006.02.008
[9]  Bonev, B. and Cavalli, G. (2016) Organization and Function of the 3D Genome. Nat Rev Genet, 17, 661-678. https://doi.org/10.1038/nrg.2016.112
[10]  Li, R., Liu, Y., Hou, Y., Gan, J., Wu, P. and Li, C. (2018) 3D Genome and Its Disorganization in Diseases. Cell Biology Toxicology, 34, 351-365. https://doi.org/10.1007/s10565-018-9430-4
[11]  Kantidze, O.L., Luzhin, A.V., Nizovtseva, E.V., Safina, A., Valieva, M.E. and Golov, A.K., et al. (2019) The Anti-Cancer Drugs Curaxins Target Spatial Genome Organization. Nature Communications, 10, 1441. https://doi.org/10.1038/s41467-019-09500-7
[12]  O’Brien, R.L., Allison, J.L. and Hahn, F.E. (1966) Evidence for Intercalation of Chloroquine into DNA. Biochimica et Biophysica Acta, 129, 622-624. https://doi.org/10.1016/0005-2787(66)90078-5
[13]  Meshnick, S.R. (1990) Chloroquine as Intercalator: A Hypothesis Revived. Parasitology Today, 6, 77-79. https://doi.org/10.1016/0169-4758(90)90215-P
[14]  Li, G.D. (2007) Plasmodium falciparum Chloroquine Resistance Marker Protein (Pfcrmp) May Be a Chloroquine Target Protein in Nucleus. Medical Hypotheses, 68, 332-334. https://doi.org/10.1016/j.mehy.2006.07.016
[15]  Li, G.D. (2008) Pfcrmp May Play a Key Role in Chloroquine Antimalarial Action and Resistance Development. Medical Hypotheses and Research, 4, 69-73.
[16]  Misaki, T., Yamaguchi, L., Sun, J., Orii, M., Nishiyama, A. and Nakanishi, M. (2016) The Replication Foci Targeting Sequence (RFTS) of DNMT1 Functions as a Potent Histone H3 Binding Domain Regulated by Autoinhibition. Biochemical and Biophysical Research Communications, 470, 741-747. https://doi.org/10.1016/j.bbrc.2016.01.029
[17]  Matityahu, A. and Onn, I. (2018) A New Twist in the Coil: Functions of the Coiled-Coil Domain of Structural Maintenance of Chromosome (SMC) Proteins. Current Genetics, 64, 109-116. https://doi.org/10.1007/s00294-017-0735-2
[18]  Li, G.D. (2016) Certain Amplified Genomic-DNA Fragments (AGFs) May Be Involved in Cell Cycle Progression and Chloroquine Is Found to Induce the Production of Cell-Cycle-Associated AGFs (CAGFs) in Plasmodium falciparum. Open Access Library Journal, 3, e2447. https://doi.org/10.4236/oalib.1102447
[19]  Li, G.D. (2017) Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum. Open Access Library Journal, 4, e3451. https://doi.org/10.4236/oalib.1103451
[20]  Li, G.D. (2019) Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis. Open Access Library Journal, 6, e5185.
[21]  Corces, M.R. and Corces, V.G. (2016) The Three-Dimensional Cancer Genome. Current Opinion in Genetics & Development, 36, 1-7. https://doi.org/10.1016/j.gde.2016.01.002
[22]  Ibrahim, D.M. and Mundlos, S. (2020) Three-Dimensional Chromatin in Disease: What Holds Us Together and What Drives Us Apart? Current Opinion in Cell Biology, 64, 1-9. https://doi.org/10.1016/j.ceb.2020.01.003
[23]  Harris, C.C. (1976) The Carcinogenicity of Anticancer Drugs: A Hazard in Man. Cancer, 37, 1014-1023.
[24]  Cole, W.H. (1956) Everson TC. Spontaneous regression of cancer: preliminary report. Annals of Surgery, 144, 366-383. https://doi.org/10.1097/00000658-195609000-00007
[25]  Yoon, H.Y., Park, H.S., Cho, M.S., Shim, S.S., Kim, Y. and Lee, J.H. (2019) Spontaneous Remission of Advanced Progressive Poorly Differentiated Non-Small Cell Lung Cancer: A Case Report and Review of Literature. BMC Pulmonary Medicine, 19, 210. https://doi.org/10.1186/s12890-019-0978-4
[26]  Jessy, T. (2011) Immunity over Inability: The Spontaneous Regression of Cancer. Journal of natural science, biology, and medicine, 2, 43-49. https://doi.org/10.4103/0976-9668.82318
[27]  Ferner, R.E. and Aronson, J.K. (2020) Chloroquine and Hydroxychloroquine in Covid-19. BMJ, 369, 1432. https://doi.org/10.1136/bmj.m1432
[28]  Li, G.D. (2019) Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis. Open Access Library Journal, 6, e5246. https://doi.org/10.4236/oalib.1105246
[29]  Li, Y., He. Y., Liang, Z., Wang. Y., Chen, F. and Djekidel, M.N., et al. (2018) Alterations of Specific Chromatin Conformation Affect ATRA-Induced Leukemia Cell Differentiation. Cell Death & Disease, 9, 200. https://doi.org/10.1038/s41419-017-0173-6
[30]  Dekker, J., Rippe, K., Dekker, M. and Kleckner, N. (2002) Capturing Chromosome Conformation. Science, 295, 1306-1311. https://doi.org/10.1126/science.1067799
[31]  Risca, V.I. and Greenleaf, W.J. (2015) Unraveling the 3D Genome: Genomics Tools for Multiscale Exploration. Trends in Genetics, 31, 357-372. https://doi.org/10.1016/j.tig.2015.03.010

Full-Text


comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

微信:OALib Journal