Neuroleptic Malignant Syndrome (NMS) and anticholinergic toxicity are two different but clinically similar disorders that are commonly seen in neuropsychiatric and emergency toxicological settings. Rapid differential diagnosis is made more difficult by the symptoms of both disorders, which frequently include delirium, heat, and autonomic instability. Interventions that result from misidentification may be detrimental or ineffectual. Using a machine learning-driven methodology, this work attempts...

Artificial Intelligence  Psychiatry & Psychology  Drugs & Devices  Diagnostics 

This study aimed to independently assess the analytical performance of 56 routine clinical biochemistry parameters on the ABBOTT Alinity ci Series and Architect ci 8200 automated systems, ensuring compliance with ISO 15189 standards. The verification followed Scope A criteria from the Medical Biology Method Verification/Validation Guide, focusing on repeatability and reproducibility. The coefficient of variation (CV) was compared to limits established by recognized learned societies such as the ...

Diagnostics 

Pneumonia remains a significant cause of morbidity and mortality worldwide, particularly in vulnerable populations such as children and the elderly. Early detection through chest X-ray analysis plays a crucial role in timely treatment; however, reliance on radiologists can lead to variability, delays, and diagnostic errors. This paper presents a convolutional neural network (CNN) designed to automate pneumonia diagnosis from chest X-ray images, addressing the need for faster and more consistent ...

Artificial Intelligence  Diagnostics 

Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...

Neuroscience  Biological Materials  Pharmacology  Nanometer Materials  Drugs & Devices  Molecular Biology  Toxicology  Organic Polymer Materials  Medicinal Chemistry  Clinical Medicine  Bioengineering  Biotechnology  Biological Engineering  Cell Biology  Oncology  Synthetic Biology  Radiology & Medical Imaging  Diagnostics 

Artificial intelligence (AI) has been with us since the 1950s and has long since undergone major developments in its capabilities and complexities, but it has recently evolved to a point where its capabilities have been substantially enhanced, all thanks to technological advances in the field of AI and modern hardware. While AI has already found applications in medicine, new revolutionary uses for it are emerging that could profoundly impact the future of healthcare for both clinicians and patie...

Diagnostics 

Smartphone-based Oximetry device as early healthcare detection is a technological frontier. Smartphone oximetry devices offer a convenient method for remote SpO₂ monitoring and early detection of critical health issues, especially during pandemics when vital indicators are necessary. Rising healthcare demands, and the COVID-19 pandemic are recent causes necessitating the prevalence for accessible early detection tools. This research investigates smartphone oximetry device as a conveni...

Public Health  Biotechnology  Global Health  Clinical Medicine  Bioengineering  Bioinformatics  Diagnostics 

Background: The recent improvements in ultrasound technology coupled with wide availability, safety, portability, cost-effectiveness, non-ionizing with high spatial resolution renders it the initial choice of imaging for the evaluation of most musculoskeletal diseases. Ultrasound is a particularly useful tool to quickly and accurately localize and characterize pathologies of the sole. Heel pain is a common presenting complaint and affects a wide range of the adult population. Pl...

Radiology & Medical Imaging  Diagnostics 

The knee joint injuries are one of the most common injuries of the human body. Since the medical examination is often insufficient to make a clinical diagnosis, we use additional diagnostic methods such as magnetic resonance imaging and arthroscopy. The aim of this work is to compare a magnetic resonance imaging and arthroscopic examination in meniscal and anterior cruciate ligament injury diagnosis. The study included 100 patients treated by knee arthroscopy with previously performed magnetic r...

Surgery & Surgical Specialties  Diagnostics 

Thymomas are rare, slow-growing, and less aggressive anterior mediastinal tumors of epithelial origin. Its propensity for extra-thoracic spread is uncommon. Regional assessment by chest CT-scan has been the imaging modality of choice for disease staging and restaging. However, there are reported cases of hematogenous metastases to the brain, liver, pancreas, and kidneys but very rarely to the spleen. We reported a case of recurrent thymoma with metastases to the lung, pleura, and spleen. F-18 FD...

Oncology  Radiology & Medical Imaging  Diagnostics 

Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...

Dermatology  Allergy & Clinical Immunology  Clinical Medicine  Immunology  Diagnostics  Medical Genetics