Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...

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Simple mathematical model of gene expression has been studied thoroughly in this paper. We assume that protein synthesis and protein decay are deterministic in nature whereas transition from active to inactive state is totally stochastic. The probability distribution function of transcript number is calculated and evidence of binary and graded response has been observed for different reaction rates. Slow and fast kinetics have been studied explicitly. Different rate constants play a significant ...

Computational Biology  Synthetic Biology  Biophysics