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Feb 22, 2021Open AccessArticle
This article discusses the dose load of people working with a C-arm X-ray system during orthopedic procedures. We measured the effective doses received by the doctor-operator and his assistant at three points of the body—head, gonads and feet, in radiography mode (single shot) and in three sub-modes of the fluoroscopy mode—continuous fluoroscopy; 1/2 dose fluoroscopy and pulse fluoroscopy. Calculations were made for dose rate the resulting our measurements due to the fact that at the different e...
Nov 27, 2020Open AccessArticle
Warfarin is a coumarin derivative oral anticoagulant with a narrow therapeutic international normalized ratio (INR) range. Regular and accurate INR monitoring is essential for optimal anticoagulation management and to reduce the risk of adverse events. However, achieving and maintaining the therapeutic INR range are still a challenge as it is affected by several clinical and non-clinical factors. In this review paper, we analyzed how the non-clinical factors like socio-demographic, modifiable ri...
Jul 08, 2020Open AccessArticle
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
May 15, 2020Open AccessArticle
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Sep 26, 2019Open AccessArticle
This study deals with Punica granatum fruit
peels. This plant was selected because of its popularity and being highly used; it was purchased from
herbarium markets of Khartoum Sudan. The study is divided into two parts, the ...
Mar 27, 2019Open AccessArticle
Talipariti elatum (Sw.) Fryxell is an endemic tree from Cuba, also known as “Majagua”, and has traditionally been used to improve asthmatic crisis and flu, as expectorant, appetitive, emollient, sudorific and laxative. Used as ornamental in park and avenues, its wood is used to make furnitures and baseball baths. In order to offer aspects related to the quality and effectiveness of the plant, its pharmacognostic, physicochemical, ...
Dec 29, 2018Open AccessArticle
Syzygium aromaticum is used in combination with other plants as an al-coholic infusion by traditional practitioners to treat infections. It has been selected for evaluation for its antimicrobial properties to justify its use in traditional pharmacopoeia. The fruits were used as plant material while the microbial germs consisted of six reference strains: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Salmonella typh ...
Oct 26, 2018Open AccessArticle
Guettarda
calyptrata A.
Rich., originally from Cuba and known as “Contraguao”, has traditionally been
used to counteract quickly and effectively burns produced by Comocladia dentate Jacq (Guao), vegetable
species that secretes a highly caustic latex for skin and mucous membranes. A
burn is a traumatic injury resulting in local and ...
Jun 06, 2018Open AccessArticle
Objective: To evaluate the
bioequivalence between two formulations of ketoprofen after administration of a
150 mg extended release tablet (L.P. ProfenidBI？), 150 mg modified release
tablets. Methods: A single-dose cross-over, randomized study was
performed under fasting conditions with two treatments, two periods, two
...
Feb 28, 2018Open AccessArticle
Over several decades, poly
(lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and
Nano-carriers of therapeutic agents for drug delivery applications. However,
encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs)
necessitates a defined step to understand the effects and interactions of
parameters involved in production process. In pharmaceutics formulations, compared
to ...
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