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Apr 11, 2025Open    Access

Anti-C1q Antibodies as Markers of Renal Involvement in Patients with Systemic Lupus Erythematosus, Bolivar City, Venezuela

Abimael Esaul Gómez-Sifontes,Jesus Alejandro Diaz-Tablero,Yvan Jose García Gonzalez Rodriguez
Background and objectives: Lupus nephritis is one of the most common complications of Systemic Lupus Erythematosus, due to the accumulation of immunocomplexes of antigens and antibodies at the renal level. In the laboratory, serum anti-C1q antibody levels have become an important tool for monitoring and management of this disease. This study evidences the levels of anti-C1q as a marker of renal involvement in patients with SLE. Patients and methods: The study wa...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1112987


Mar 17, 2025Open    Access

The Role of Human Herpesvirus-Encoded MicroRNA in Host Virus Interaction

Bandana Pandey
Human Herpesviruses (HHVs) are a group of large DNA viruses that can establish lifelong infections in their hosts. They achieve this by switching between two phases: the lytic phase, where the virus actively replicates, and the latent phase, where the virus remains dormant but can reactivate later. A key factor in this process is microRNAs (miRNAs)—small, non-coding RNA molecules that regulate gene expression. In human cells, miRNAs play a crucial role in controlling various biological processes...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1113043


Jul 26, 2024Open    Access

COVID-19 Vaccine Acceptance and Hesitancy among Healthcare Workers at a Teaching Hospital in Zambia: Findings and Implications

Steward Mudenda,Banji Moonga,Maisa Kasanga,Victor Daka,Ngoni Veddie Muzondo,Ruth Lindizyani Mfune,Shafiq Mohamed,Nathan Mugenyi,Manal Hadi Ghaffoori Kanaan,Billy Chabalenge
Introduction: The coronavirus disease (COVID-19) vaccines provided renewed hope in the fight against the COVID-19 pandemic. To promote extensive vaccination coverage, it is imperative to assess the inclination towards receiving vaccines and examine the influencing factors among healthcare workers (HCWs). This study evaluated COVID-19 vaccine acceptance and hesitancy among HCWs at a Teaching Hospital in Zambia. Materials and Methods: This cross-sectional study wa...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111827


May 11, 2024Open    Access

Ultrasound-Guided Stellate Ganglion Block on Sleep Disorders in Patients Recovered from COVID-19

Pu Chen,Yuping Hu,Nana Zhang
Objective: This study aimed to observe the therapeutic effect of ultra-sound-guided stellate ganglion block (U-SCG) on sleep disorders in pa-tients who have recovered from COVID-19. Methods: A retrospective analysis was conducted on 39 patients with post-COVID-19 sleep disorders treated at the Department of Anesthesiology, Fourth Affiliated Hospital of Nanjing Medical University. The treatment involved a 7-day course of U-SCG, and the improvement in sleep was as...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111525


Jul 21, 2023Open    Access

Atopic Dermatitis Related to RNF31 Genetic Variant

César Daniel Alonso-Bello, Sonia del Carmen Chávez-Ocana, Carol Vivian Moncayo-Coello, María Isabel Rojo-Gutierrez
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110339


Feb 09, 2023Open    Access

A Case Report: Persistent Kodamaea ohmeri Fungaemia Due to Peritoneal Infection

Tasnim Rosli, Anuradha P. Radhakrishnan, Alif Adlan M. Thabit, Salina Mohamed Sukur
Kodamaea (Pichia) ohmeri is a rare and emerging yeast-like fungus that belongs to the ascomycete group and Saccharomycetaceae family. It is an important pathogen in immunocompromised patients, they were reported as fungemia, funguria, endocarditis, peritonitis and wound infections causing necrotising fasciitis. We describe a case where Kodamaea ohmeri isolated from peritoneal infection in an elderly patient that came with retroperitoneal collection as a complication o...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109730


Jan 28, 2023Open    Access

Profile of Patients Who Consulted at the Center for Mixed Medicine and SS Anemia from January 1, 2018 to December 31, 2020

Paulin Mulowayi, Berry I. Bongenya, Ben I. Bulanda, Elvis T. Kateba, Charlotte L. Tshinguta, Steve Kodondi, Christian P. Vangu, Blezz Nkolomoni, Erick N. Kamangu
Context: Sickle cell disease is the most widespread genetic hematological disease in the world and constitutes a real public health problem with an increasingly increasing prevalence. Objective: The objective of this study was to determine the profile of patients who consulted at the Center for Mixed Medicine and SS Anemia in Kinshasa. Methods: A retrospective descriptive study of the data available in the files of patients who consulted the CMMASS during the period from January 1, 2018 to Decem...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109438


Jan 04, 2023Open    Access

Sociodemographic Profile and Clinic of Polytransfused Sickle Cell Patients in Kinshasa: Case of the Center for Mixed Medicine and SS Anemia

Alain K. K. Ilunga, Gisèle K. Kabengele, Tarcisse K. Kilara, Cagod B. Inkale, Isaac T. Woto, Simplice K. Makoka, Gloria Y. Kangite, Bernard Masikini, Rycklain B. Misengele, Christine M. Katuanda, Christian P. Vangu, Berry I. Bongenya, Dieudonné T. Nyembue, Erick N. Kamangu
Background: Sickle cell disease is an autosomal recessive hereditary hemoglobinopathy. Patients with sickle cell disease (HbSS, Sβ, SC phenotypes) with permanent hemolytic anemia very often require transfusions. Objective: To describe the socio-demographic and clinical characteristics of polytransfused sickle cell patients in Kinshasa. Methods: This is a descriptive cross-sectional study of polytransfused sickle cell patients followed at the SS Anemia Mixed Medicine Center (CMMASS). Socio-demogr...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109222


Nov 25, 2022Open    Access

Guillain-Barré Syndrome Following AstraZeneca COVID-19 Vaccine

Ali Mikdad Hassan, Syeda Marium, Paras Yousuf, Asad Akram Farooqi, Uzair Yaqoob
It’s been more than two years since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Wuhan, China, in December 2019, and still Coronavirus-19 (COVID-19) is an ongoing burden in many parts of the world. Currently, few vaccines are approved by the World Health Organization (WHO) and are being administered to people to boost their immunity. Since the outbreak of this disease, the number of patients getting vaccinated is increasing with every passing day...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109510


Sep 30, 2022Open    Access

Clinical Profile of People Living with Human Immunodeficiency Virus Starting Treatment in Kinshasa, Democratic Republic of Congo

Grace Ipaya Booto, Stéphanie Mauwa Selenge, Berry Ikolanga Bongenya, Thérèse Kaseka Ntumba, Lambert Omombo Losenga, Noella Makela Dikati, Rosalie Djamba Dembo, Jocelyn Ewuti Nonga, Candide About Kabamba, Benoit Obel Kabengele, Marie-Thérèse Ayanne-Safi Sombo, Guy Makila-Mabe Bumoko, Erick Ntambwe Kamangu
Context: For several decades, the introduction of AntiRetroViral (ARV) has allowed an improvement in the clinical signs of patients, a spectacular reduction in mortality and morbidity, an extension of life and an improvement in the quality of life of many People Living with HIV (PLHIV). Objective: The objective of this study was to determine the clinical profile of PLHIV starting ARV Treatment in Kinshasa in the era of Dolutegravir. Methods: This study is a descriptive cross-sectional study to d...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109134


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