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May 18, 2022Open    AccessArticle

Exploring the Potential of Non-Pharmacological Therapeutic Interventions to Promote Resilience of the Human Immune System. Part I: Biological Foundations and Structured Exercise

Craig Parker
The human immune system relies on the dynamic, complex integration of various cells, proteins, tissues, and organs which work together in concert with the nervous system to recognize, adapt to, and neutralize pathogens. In parallel, there is a neurobiological network of systems which function to react and adapt to changes in the environment to restore and maintain homeostasis in the service of survival. Our dependency on the stability and resilience of this collective ecosystem of responses is a...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108691


Apr 25, 2022Open    AccessArticle

Selected Biochemical Values of Suitable Blood Donors at Kenyatta National Hospital

Jackson Ireri Mrama
Background: Clinical values derived from groups of apparently normal individuals are used for the determination of reference ranges. Only individuals with good health are recruited as blood donors and so can form a suitable cohort for the development of reference intervals. Reference intervals are necessary in interpreting and making critical decisions in diagnostic and research purposes. In this cross-section study, male and female selected biochemical values were determined on blood donors att...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108611


Jan 14, 2020Open    AccessArticle

Phenocopies: Mimics of Inborn Errors of Immunity

Cesar Daniel Alonso-Bello, Sara Elva Espinosa-Padilla, Mariano Daniel Temix-Delfin, Fernando Lozano-Patino, Victoria Isabel Castaneda-Avila, Maria Eugenia Vargas-Camano, María Isabel Castrejón-Vázquez
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are ca
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Open Access Library J.   Vol.7, 2020
Doi:10.4236/oalib.1106041


Feb 28, 2019Open    AccessArticle

Effect of Dioscorea Pills on Immunity of Mice Receiving Chemotherapy for Ovarian Cancer

Yiming Tang, Huijun Xu
Objective: To observe the effect of Dioscorea pills on the immunity of mice with ovarian cancer after chemotherapy and its mechanism of action. Methods: BALB/C mice were randomly divided into blank group, ovarian cancer model group, chemotherapy group and chemotherapy plus TCM (Traditional Chinese Medicine) group with 20 mice in each group. Except the blank group, 60 mice in other groups were subcutaneously injected with SKOV-3 ov
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Open Access Library J.   Vol.6, 2019
Doi:10.4236/oalib.1105247


Nov 28, 2017Open    AccessArticle

The Novel Patient with BLNK Gene Type of Agammaglobulinemia

Gulnara Mahammadali Nasrullayeva, Vafa Rustam Mammadova, Afaq Vladimr Khalilova, Shabnam Eldar Shahgeldiyeva
Background: Agammaglobulinemia (AGM) is a genetic immune system disorder in which the body could not produce antibodies. There are two types of this disease: X-linked AGM (XLA) and autosomal forms. X-linked agammaglobulinemia results from a mutation in the gene for Bruton’s tyrosine kinase (BTK), found on the X chromosome. Mutations in BTK result in lack of mature B-cells and immunoglobulins of all classes. Th
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Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1104114


Apr 27, 2017Open    AccessArticle

JAK-STAT Lodges in Multiple Sclerosis: Pathophysiology and Therapeutic Approach Overview

Kabir Magaji Hamid, Abdullahi Isiyaku, Mustapha Umar Kalgo, Isah Suleiman Yahaya, Abbas Mirshafiey
Multiple sclerosis (MS) is a complex inflammatory and demyelinating disease of central nervous system (CNS). The disease pathogenesis is not fully understood and no actual cure for the disease yet. The disease has genetic and environmental cause as fundamental factors which are identified for the disease pathogenesis so far. One of the characteristic features of the disease is inflammation cause due to activation of pro-inflammato
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Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1103492


Apr 12, 2017Open    AccessArticle

Virological and Serological Markers in Dengue Patients from Venezuela and Nicaragua

Didye Ruiz, Susana Vázquez, Elci Villegas, Angel Balmaseda, Maritza Pupo, Mayling Alvarez, Delfina Rosario, Herminia Bendezu, Naifi Calzada, Maria G. Guzman
Latest estimates suggest 390 million infections of dengue occur each year, of which 100 million results in symptomatic disease. The new clinical classification proposed by WHO-TRD 2009 simplifies dengue fever (DF) into dengue (D) and severe dengue (SD) with an intermediary group of “dengue with warning signs” (DWS). Early, sensitive and specific diagnosis of dengue is needed for appropriate patient managem
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Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1103309


Nov 29, 2016Open    AccessArticle

Immunoglobulin A Antibody Responses in Patients with Primary or Secondary Dengue Infections

Didye Ruiz, Susana Vázquez, Hernán C. Ríos, Naifi Calzada, María G. Guzmán
IgM serological diagnostic plays an important role in the dengue epidemiological surveillance. However, IgA has been identified as a possible diagnostic marker for early stage and recent infections. The aim of this study was to know the IgA response in dengue patients in relation to type of infection, serotype specificity and role as early and recent infection marker. IgA behavior in dengue patients, using a method de
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Open Access Library J.   Vol.3, 2016
Doi:10.4236/oalib.1103212


Aug 03, 2016Open    AccessArticle

Shared Autoimmunity: A Case Series of 56 Patients with Immune Thrombocytopenia (ITP) Associated with Other Autoimmune Disorders

Lizbeth-Estefanía Díaz-Polo, Núria Pujol-Moix, Blanca Jiménez, Carme Canals, Edgardo Barranco-Charris, Eduardo Muniz-Díaz, Juan-Carlos Souto
The association of two or more autoimmune disorders in the same individual has been attributed to “shared autoimmunity” caused by the interaction between genetic and environmental factors. We present the retrospective analysis of 56 patients with Immune Thrombocytopenia (ITP) associated with other autoimmune disorders. Age, sex, clinical manifestations, platelet count, platelet autoantibodies and therapeutic responses were similar
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Open Access Library J.   Vol.3, 2016
Doi:10.4236/oalib.1102807


Jun 15, 2016Open    AccessArticle

Assessment of Immunization Status, Coverage and Determinants among under 5-Year-Old Children in Owerri, Imo State, Nigeria

Chukwuma B. Duru, Anthony C. Iwu, Kenechi A. Uwakwe, Kevin C. Diwe, Irene A. Merenu, Chima A. Emerole, Chioma A. Adaeze, Chinwe U. Onyekuru, Obinna Ihunnia
Background: Immunization coverage in different parts of the country varies widely despite efforts to improve the services. The immunization status of children is dependent on the dynamics of vaccination uptake which is complex and involves the interplay of different associated factors. Aim: To determine the immunization coverage, status and the determinants in under 5-year-old children in Owerri municipal, Imo State. Methods: The
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Open Access Library J.   Vol.3, 2016
Doi:10.4236/oalib.1102753


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