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May 18, 2022Open AccessArticle
The human immune system relies on the dynamic, complex integration of various cells, proteins, tissues, and organs which work together in concert with the nervous system to recognize, adapt to, and neutralize pathogens. In parallel, there is a neurobiological network of systems which function to react and adapt to changes in the environment to restore and maintain homeostasis in the service of survival. Our dependency on the stability and resilience of this collective ecosystem of responses is a...
Apr 25, 2022Open AccessArticle
Background: Clinical values derived from groups of apparently normal individuals are used for the determination of reference ranges. Only individuals with good health are recruited as blood donors and so can form a suitable cohort for the development of reference intervals. Reference intervals are necessary in interpreting and making critical decisions in diagnostic and research purposes. In this cross-section study, male and female selected biochemical values were determined on blood donors att...
Jan 14, 2020Open AccessArticle
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are ca ...
Feb 28, 2019Open AccessArticle
Objective: To observe the effect of Dioscorea pills on the immunity of mice with ovarian cancer after chemotherapy and its mechanism of action. Methods: BALB/C mice were randomly divided into blank group, ovarian cancer model group, chemotherapy group and chemotherapy plus TCM (Traditional Chinese Medicine) group with 20 mice in each group. Except the blank group, 60 mice in other groups were subcutaneously injected with SKOV-3 ov ...
Nov 28, 2017Open AccessArticle
Background:
Agammaglobulinemia (AGM) is a genetic immune system disorder in which the body
could not produce antibodies. There are two types of this disease: X-linked AGM
(XLA) and autosomal forms. X-linked agammaglobulinemia results from a mutation
in the gene for Bruton’s tyrosine kinase (BTK), found on the X chromosome.
Mutations in BTK result in lack of mature B-cells and immunoglobulins of all
classes. Th ...
Apr 27, 2017Open AccessArticle
Multiple sclerosis (MS) is
a complex inflammatory and demyelinating disease of central nervous system
(CNS). The disease pathogenesis is not fully understood and no actual cure for
the disease yet. The disease has genetic and environmental cause as fundamental
factors which are identified for the disease pathogenesis so far. One of the characteristic
features of the disease is inflammation cause due to activation of pro-inflammato ...
Apr 12, 2017Open AccessArticle
Latest
estimates suggest 390 million infections of dengue occur each year, of which
100 million results in symptomatic disease. The new clinical classification
proposed by WHO-TRD 2009 simplifies dengue fever (DF) into dengue (D) and
severe dengue (SD) with an intermediary group of “dengue with warning
signs” (DWS).
Early, sensitive and specific diagnosis of dengue is needed for appropriate patient managem ...
Nov 29, 2016Open AccessArticle
IgM serological diagnostic
plays an important role in the dengue epidemiological surveillance. However,
IgA has been identified as a possible diagnostic marker for early stage and
recent infections. The aim of this study was to know the IgA response in dengue
patients in relation to type of infection, serotype specificity and role as
early and recent infection marker. IgA behavior in dengue patients, using a method de ...
Aug 03, 2016Open AccessArticle
The association of two or more autoimmune disorders in the same individual
has been attributed to “shared autoimmunity” caused by the interaction between genetic
and environmental factors. We present the retrospective analysis of 56 patients
with Immune Thrombocytopenia (ITP) associated with other autoimmune disorders. Age,
sex, clinical manifestations, platelet count, platelet autoantibodies and therapeutic
responses were similar ...
Jun 15, 2016Open AccessArticle
Background: Immunization coverage in different parts of the country varies
widely despite efforts to improve the services. The immunization status of
children is dependent on the dynamics of vaccination uptake which is complex
and involves the interplay of different associated factors. Aim: To determine
the immunization coverage, status and the determinants in under 5-year-old children
in Owerri municipal, Imo State. Methods: The ...
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