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Apr 11, 2025Open Access
Background and objectives: Lupus nephritis is one of the most common complications of Systemic Lupus Erythematosus, due to the accumulation of immunocomplexes of antigens and antibodies at the renal level. In the laboratory, serum anti-C1q antibody levels have become an important tool for monitoring and management of this disease. This study evidences the levels of anti-C1q as a marker of renal involvement in patients with SLE. Patients and methods: The study wa...
Mar 17, 2025Open Access
Human Herpesviruses (HHVs) are a group of large DNA viruses that can establish lifelong infections in their hosts. They achieve this by switching between two phases: the lytic phase, where the virus actively replicates, and the latent phase, where the virus remains dormant but can reactivate later. A key factor in this process is microRNAs (miRNAs)—small, non-coding RNA molecules that regulate gene expression. In human cells, miRNAs play a crucial role in controlling various biological processes...
Jul 26, 2024Open Access
Introduction: The coronavirus disease (COVID-19) vaccines provided renewed hope in the fight against the COVID-19 pandemic. To promote extensive vaccination coverage, it is imperative to assess the inclination towards receiving vaccines and examine the influencing factors among healthcare workers (HCWs). This study evaluated COVID-19 vaccine acceptance and hesitancy among HCWs at a Teaching Hospital in Zambia. Materials and Methods: This cross-sectional study wa...
May 11, 2024Open Access
Objective: This study aimed to observe the therapeutic effect of ultra-sound-guided stellate ganglion block (U-SCG) on sleep disorders in pa-tients who have recovered from COVID-19. Methods: A retrospective analysis was conducted on 39 patients with post-COVID-19 sleep disorders treated at the Department of Anesthesiology, Fourth Affiliated Hospital of Nanjing Medical University. The treatment involved a 7-day course of U-SCG, and the improvement in sleep was as...
Jul 21, 2023Open Access
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Feb 09, 2023Open Access
Kodamaea ( Pichia) ohmeri is a rare and emerging yeast-like fungus that belongs to the ascomycete group and Saccharomycetaceae family. It is an important pathogen in immunocompromised patients, they were reported as fungemia, funguria, endocarditis, peritonitis and wound infections causing necrotising fasciitis. We describe a case where Kodamaea ohmeri isolated from peritoneal infection in an elderly patient that came with retroperitoneal collection as a complication o...
Jan 28, 2023Open Access
Context: Sickle cell disease is the most widespread genetic hematological disease in the world and constitutes a real public health problem with an increasingly increasing prevalence. Objective: The objective of this study was to determine the profile of patients who consulted at the Center for Mixed Medicine and SS Anemia in Kinshasa. Methods: A retrospective descriptive study of the data available in the files of patients who consulted the CMMASS during the period from January 1, 2018 to Decem...
Jan 04, 2023Open Access
Background: Sickle cell disease is an autosomal recessive hereditary hemoglobinopathy. Patients with sickle cell disease (HbSS, Sβ, SC phenotypes) with permanent hemolytic anemia very often require transfusions. Objective: To describe the socio-demographic and clinical characteristics of polytransfused sickle cell patients in Kinshasa. Methods: This is a descriptive cross-sectional study of polytransfused sickle cell patients followed at the SS Anemia Mixed Medicine Center (CMMASS). Socio-demogr...
Nov 25, 2022Open Access
It’s been more than two years since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Wuhan, China, in December 2019, and still Coronavirus-19 (COVID-19) is an ongoing burden in many parts of the world. Currently, few vaccines are approved by the World Health Organization (WHO) and are being administered to people to boost their immunity. Since the outbreak of this disease, the number of patients getting vaccinated is increasing with every passing day...
Sep 30, 2022Open Access
Context: For several decades, the introduction of AntiRetroViral (ARV) has allowed an improvement in the clinical signs of patients, a spectacular reduction in mortality and morbidity, an extension of life and an improvement in the quality of life of many People Living with HIV (PLHIV). Objective: The objective of this study was to determine the clinical profile of PLHIV starting ARV Treatment in Kinshasa in the era of Dolutegravir. Methods: This study is a descriptive cross-sectional study to d...
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