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Jan 08, 2025Open Access
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...
Nov 18, 2024Open Access
Background: Chronic pain management presents significant challenges in clinical practice, particularly in selecting pharmacological treatments that balance efficacy and safety. GABAergic and opioid medications are two commonly prescribed drug classes for pain relief, but their comparative effectiveness and safety profiles remain a topic of ongoing debate. Objectives: This study aims to compare the effectiveness and safety of GABAergic and opioid medications in m...
Nov 15, 2024Open Access
Background: Monoamine oxidase inhibitors (MAOIs) were among the earliest antidepressants developed and remain a viable treatment option, particularly for patients with treatment-resistant depression (TRD). This report presents two cases of TRD successfully treated with MAOIs after failure of multiple antidepressants. Objective: To evaluate the efficacy of MAOIs in patients with major depressive disorder (MDD) who did not respond to selective serotonin reuptake i...
Nov 07, 2024Open Access
Background: Tricyclic antidepressants (TCAs) have historically played a central role in treating depression but are often overshadowed by newer antidepressants due to their side effect profiles. However, TCAs remain a valuable option, particularly for patients with treatment-resistant depression (TRD), where other medications fail to achieve symptom remission. Objective: This study aims to evaluate the efficacy of TCAs in resolving treatment-resistant depression...
Nov 07, 2024Open Access
Background: Antipsychotic medications are crucial for managing psychiatric disorders such as schizophrenia, but their use can lead to side effects. This study compares the efficacy and side effects of monotherapy versus bi-therapy in the treatment of schizophrenia. Bi-therapy, also known as dual therapy or combination therapy, refers to the use of two medications simultaneously to treat a medical condition. Objective: This paper aims to evaluate the comparative ...
Oct 10, 2024Open Access
Functionalized graphene oxide (GO), known for its unique physicochemical properties and biocompatibility, has demonstrated significant potential in the realms of drug delivery and biomedical imaging. This review initially presents the chemical functionalization approaches for GO, including surface modification and doping techniques, which notably enhance its stability and functionality for biomedical applications. Subsequently, it delves into the applications of functionalized GO in drug deliver...
Aug 28, 2024Open Access
The integration of the Internet of Things (IoT) in healthcare, particularly through wearable health monitoring devices (WHMDs), has the potential to significantly enhance elderly care by promoting active aging and remote health management. This study aims to explore the experiences, motivations, and challenges faced by older adults using WHMDs through a qualitative systematic review. We conducted a systematic search across six electronic databases and selected 18 studies conducted in 10 countrie...
Feb 08, 2023Open Access
Introduction: The word cosmeceutical was first conceived in 1961 by Raymond Reed. The term was further popularized by Dr. Albert Kligman in 1984 and by 1996 the cosmeceuticals products made their first appearance in the world market. The word “cosmeceutical” continues to evolve since then to date. However, most people are either ignorant of it or confused it with cosmetics generally. It lacks a proper definition and its difference from individual cosmetics and pharmaceutical agents seem to be in...
Jan 31, 2023Open Access
Development of drug-resistant lines in rodent malaria parasites left us a deep impression on antidrug specificity of antimalarial drug-resistant lines, which is similar to antigen-induced antibody. Based on this comparison, “specific antidrug substance” was proposed to explain antidrug specificity of drug-resistant lines. If “specific antidrug substance” refers to a protein that is quite like antibody, the concept of “specific antidrug substance” is wrong because no such protein has been discove...
Dec 23, 2022Open Access
Based on a novel antiviral theory, we propose that taking paracetamol and vitamin C or ibuprofen and vitamin C every day could be a very simple way to prevent COVID-19 infection. To prove the effectiveness of these drug combinations, urgent clinical trials should be carried out. Mass drug administration plays a very important role in the containment of COVID-19 pandemic. Prophylactic drugs might not provide 100% protection, but can reduce coronavirus deaths and severe cases, which might facilita...
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