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Jan 08, 2025Open    Access

Advancement in Nanoparticle-Based NIRF Probes for Precision Visualization in Oncology

Michael Adeniyi
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...
Open Access Library J.   Vol.12, 2025
Doi:10.4236/oalib.1112471


Nov 18, 2024Open    Access

Comparative Analysis of GABAergics vs. Opioids in Chronic Pain Management

Rocco de Filippis,Abdullah Al Foysal
Background: Chronic pain management presents significant challenges in clinical practice, particularly in selecting pharmacological treatments that balance efficacy and safety. GABAergic and opioid medications are two commonly prescribed drug classes for pain relief, but their comparative effectiveness and safety profiles remain a topic of ongoing debate. Objectives: This study aims to compare the effectiveness and safety of GABAergic and opioid medications in m...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112388


Nov 15, 2024Open    Access

Case Report: The Role of Monoamine Oxidase Inhibitors in Treating Resistant Depression

Rocco de Filippis,Abdullah Al Foysal
Background: Monoamine oxidase inhibitors (MAOIs) were among the earliest antidepressants developed and remain a viable treatment option, particularly for patients with treatment-resistant depression (TRD). This report presents two cases of TRD successfully treated with MAOIs after failure of multiple antidepressants. Objective: To evaluate the efficacy of MAOIs in patients with major depressive disorder (MDD) who did not respond to selective serotonin reuptake i...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112369


Nov 07, 2024Open    Access

Case Report: The Role of Tricyclic Antidepressants in Treating Resistant Depression

Rocco de Filippis,Abdullah Al Foysal
Background: Tricyclic antidepressants (TCAs) have historically played a central role in treating depression but are often overshadowed by newer antidepressants due to their side effect profiles. However, TCAs remain a valuable option, particularly for patients with treatment-resistant depression (TRD), where other medications fail to achieve symptom remission. Objective: This study aims to evaluate the efficacy of TCAs in resolving treatment-resistant depression...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112368


Nov 07, 2024Open    Access

Comparative Analysis of Monotherapy and Bi-Therapy in Antipsychotic Treatment

Rocco de Filippis,Abdullah Al Foysal
Background: Antipsychotic medications are crucial for managing psychiatric disorders such as schizophrenia, but their use can lead to side effects. This study compares the efficacy and side effects of monotherapy versus bi-therapy in the treatment of schizophrenia. Bi-therapy, also known as dual therapy or combination therapy, refers to the use of two medications simultaneously to treat a medical condition. Objective: This paper aims to evaluate the comparative ...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1112367


Oct 10, 2024Open    Access

Applications of Functionalized Graphene Oxide in Drug Delivery and Biomedical Imaging

Chihuan Han, Wenshu Ma,Yan La,Xiaoshuai Gu,Juan Ma,Xusheng Zhang
Functionalized graphene oxide (GO), known for its unique physicochemical properties and biocompatibility, has demonstrated significant potential in the realms of drug delivery and biomedical imaging. This review initially presents the chemical functionalization approaches for GO, including surface modification and doping techniques, which notably enhance its stability and functionality for biomedical applications. Subsequently, it delves into the applications of functionalized GO in drug deliver...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111549


Aug 28, 2024Open    Access

Exploring the Experiences of Wearable Health Monitoring Devices among the Aging Population: A Qualitative Systematic Review

Atisi Lawson Hayford,Jomin George
The integration of the Internet of Things (IoT) in healthcare, particularly through wearable health monitoring devices (WHMDs), has the potential to significantly enhance elderly care by promoting active aging and remote health management. This study aims to explore the experiences, motivations, and challenges faced by older adults using WHMDs through a qualitative systematic review. We conducted a systematic search across six electronic databases and selected 18 studies conducted in 10 countrie...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111957


Feb 08, 2023Open    Access

Awareness and Use of Cosmeceuticals among Female Students of Tertiary Institutions in Northeastern Nigeria

Mohammed Tahiru Bolori, Bukar Umar Bolori, Amina Baba Kuchichi, Ibrahim Musa Ngoshe, Fati Lawan Bukar, Mary Olubisi Amodu, Sana Arshad, Somia Gutbi Salim Mohamed, Halim Rahamtalla Mohamed Ahmed
Introduction: The word cosmeceutical was first conceived in 1961 by Raymond Reed. The term was further popularized by Dr. Albert Kligman in 1984 and by 1996 the cosmeceuticals products made their first appearance in the world market. The word “cosmeceutical” continues to evolve since then to date. However, most people are either ignorant of it or confused it with cosmetics generally. It lacks a proper definition and its difference from individual cosmetics and pharmaceutical agents seem to be in...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109717


Jan 31, 2023Open    Access

Drug Resistance in Malaria Parasites: Does “Specific Antidrug Substance” Exist?

Gao-De Li
Development of drug-resistant lines in rodent malaria parasites left us a deep impression on antidrug specificity of antimalarial drug-resistant lines, which is similar to antigen-induced antibody. Based on this comparison, “specific antidrug substance” was proposed to explain antidrug specificity of drug-resistant lines. If “specific antidrug substance” refers to a protein that is quite like antibody, the concept of “specific antidrug substance” is wrong because no such protein has been discove...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1109691


Dec 23, 2022Open    Access

Taking Paracetamol and Vitamin C or Ibuprofen and Vitamin C Every Day Could Be a Simple Way to Prevent COVID-19 Infection

Gao-De Li
Based on a novel antiviral theory, we propose that taking paracetamol and vitamin C or ibuprofen and vitamin C every day could be a very simple way to prevent COVID-19 infection. To prove the effectiveness of these drug combinations, urgent clinical trials should be carried out. Mass drug administration plays a very important role in the containment of COVID-19 pandemic. Prophylactic drugs might not provide 100% protection, but can reduce coronavirus deaths and severe cases, which might facilita...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109544


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