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May 10, 2024Open    Access

Prevalence, Antimicrobial Susceptibility Profile of Citrobacter and Risk Factors Associated with Diarrheal Diseases in Water Wells in Urban West Region, Zanzibar

Gharibu A. Ibrahim,Alexanda Mzula,Isaac Makundi,Elisa Mwega
Citrobacter are Gram-negative bacteria that give public health challenges due to their zoonotic infections. Diarrheal diseases and antimicrobial resistance are global concerns that increase the burden of implementing infectious disease monitoring, especially in poor economic countries. This study was conducted to determine the prevalence and antimicrobial susceptibility and assess the risk factors of diarrheal diseases caused by bacteria from drinking water wells in the Urban West Regio...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111232


Oct 31, 2023Open    Access

Molecular Detection of Plasmodium falciparum and Plasmodium falciparum Chloroquine Resistance Transporter Gene from Microscopy-Confirmed Malaria in Febrile Patients at the Federal Teaching Hospital Gombe Nigeria

Fatima Abdullahi Baba, Haruna Adamu, Zainab Saleh Maigana, Nusaiba Saleh
Malaria is a parasitic disease caused by the protozoan parasites Plasmodium species, and usually transmitted through the bite of a female Anopheles species mosquito. Plasmodium falciparum is regarded as the most lethal of the Plasmodium species and most efforts are geared towards its control. Hitherto, with no available vaccines, an antimalarial drug such as Chloroquine was the main stay in the clinical management of uncomplicated P. falciparum malari...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110783


Aug 18, 2023Open    Access

Biotechnological Drug Development—The Role of Proteins, Genes, In-Silico, and Stem Cells in Designing Models for Enhanced Drug Discovery

Taofik Ahmed Suleiman, Ann Christopher Francis, Abdulwasiu Ibrahim, Adedoyin Owolade Jonn-Joy, Ebenezer Adebiyi, Daniel Tweneboah Anyimadu
The application of biotechnology in drug discovery has been discovered to be a promising and resourceful approach for the discovery of novel therapeutic candidates that comes with less time and cost than the traditional ways of drug discovery. This has additionally endowed researchers with the necessary understanding of diseases, which offers exceptional methods for treating patients. Additionally, diagnosis and treatment are becoming increasingly intertwined with the help of biotechnology. Toda...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110520


Jun 28, 2023Open    Access

Differential Gene Expression Analysis on Workers Exposed to Pesticides: Genetic Damage and Cancer Susceptibility

Fábio Morato de Oliveira, Caio Fernando de Oliveira Pereira Passos, Hellen Miranda Campos, Gabriella Leite Sampaio, Leandro Hirata Mendes, Wagner Gouvêa dos Santos, Aline Monezi Montel, Tamara Rodrigues Lima Zanuzzi, Edlaine Faria de Moura Villela
We performed aurora kinase gene expression analysis, in combination with FISH and micronucleus test, in buccal mucosa cells isolated from agricultural workers to better understand the dynamics of genomic instability in these groups of professionals. Two out of a total of 97 agricultural workers who consented to participate in the study (39 men and 58 women) reported a history of cancer based on a previously applied questionnaire. The participants were 28.4 years on average and were categorized i...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110297


Aug 19, 2022Open    Access

Blotting: A Smart Strategy for Enabling the Detection of Molecules of Interest

Suxiang Chen
Blotting is a classical technique for detecting macro-biomolecules of interest from a mixture of molecules. The technique is generally composed of four steps: 1) gel electrophoresis-based separation of molecules, 2) blotting (transfer and immobilization) of separated molecules from the gel onto the membrane, 3) specific hybridization of probes to target molecules on the membrane, and 4) visualization of the probe/target molecule complex. The present article briefly introduces blotting techniques...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1109160


Jun 10, 2022Open    Access

Taxonomy and Characterization of Fungi Isolated from Cocoa Beans during Fermentation in Saf’s Agroforestry System in the Amazon

Mateus Cardoso Barros, Jeferson Santana Quadros, Magnun Antonio Penariol da Silva, Raquel Soares Casaes Nunes
Agroforestry systems (SAFs) are an alternative for sustainable development as they enable the recovery of degraded areas and reduce deforestation, contributing to breaking the cycle of traditional family farming, so common in the Amazon region, which enables the recovery of soils, the increase of organic matter and soil fertility. Cocoa beans are grown and fermented in SAFs. According to the research, the significant appearance of endophytic microorganisms such as fungi in the cocoa bean can ben...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108825


Apr 24, 2022Open    Access

Kernel PCA Based Non-Local Means Method for Speckle Reduction in Medical Ultrasound Images

Musab Elkheir Salih, Xuming Zhang, Mingyue Ding
The speckle noise is considered one of the main causes of degradation in ultrasound image quality. Many despeckling filters have been proposed, which are always making a trade-off between noise suppression and loss of information. A class of despeckling methods based Non-Local Means (NLM) algorithm is known to efficiently preserve the edges and all fine details of an image while reducing the noise. The core idea of NLM filter is to estimate the denoised pixel by performing a weighted average of ...
Open Access Library J.   Vol.9, 2022
Doi:10.4236/oalib.1108618


Nov 08, 2021Open    Access

Serpocaulon orosiense, a New Hybrid of Serpocaulon (Polypodiaceae) from Costa Rica

Alexander Francisco Rojas-Alvarado, Lucía Barrantes-Calvo
Four hybrids between Serpocaulon species have been described, one of them S. × sessilipinnum was the only known hybrid between two different clades proposed by Smith et al. In this work, a new hybrid S. × orosiense is described, being the second known hybrid between clades: 1) Serpocaulon loriceum and 2) S. fraxinifolium. The detailed study of the intermediate morphology of the characters of the new taxon and their progenitors were made by ...
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1108047


Jul 29, 2021Open    Access

Biotechnology Application of Therapeutic Antibody Drug Discovery and Preparation

Huilin Cao
According to the technical application, therapeutic mechanism and application prospect of therapeutic antibodies are discussed from the research and development of therapeutic antibodies to their application technology. Also, following is a list of some disadvantages of the drug. May this article shall lead perspective in the next section.
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107719


Jun 28, 2021Open    Access

Wnt5a Role in Cisplatin Effect and Selectivity Augmentation in Cancer Therapy

Waleed O. Atta, Ahmed Z. Abdel Azeiz
Wnt5a is a representative protein ligand that activates a beta catenin independent pathway in Wnt signaling in cancer progression and spread in the palmitoylated form. So that its synthesis is augmented through promotion of its gene transcription in the malignant cells. Cisplatin is an important chemotherapeutic drug used in treatment of different types of advanced cancer. However, its usage is limited due to severe dose-limiting side effects, due to the lack of targeting therapy of cisplatin. O...
Open Access Library J.   Vol.8, 2021
Doi:10.4236/oalib.1107564


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