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Mar 17, 2026Open Access
The mechanisms underlying accelerated cognitive decline in Alzheimer’s disease (AD) remain incompletely understood. Accumulating evidence suggests that AD is a complex, multifactorial neurodegenerative disorder in which oxidative stress plays a central role. Oxidative stress, often triggered by amyloid-β (Aβ)-induced reactive oxygen species (ROS), leads to severe cellular damage and contributes to cognitive deterioration. This study investigated the effects of phenylethanoid glycosides (AIE ...
Dec 26, 2025Open Access
Staphylococcus aureus is an important foodborne pathogen that is of major concern to public health especially when it becomes resistant to a last-line drug of choice like vancomycin. As the use of plant derived drinks such as soy milk have grown, the issue of microbial contamination and antimicrobial resistance is also of greater concern particularly in regions with little regulations. This study was done to determine the occurrence of Vancomycin-Resistant Staphylococcus aureus (VRSA) in soy mil...
May 14, 2025Open Access
Deltamethrin, as a widely used pyrethroid insecticide, has caused significant environmental pollution due to its persistence and non-degradability in soil. Therefore, the immobilized microbial technology has shown good application potential due to its low cost and quick effect. Among them, Aspergillus niger as the representative of 17 kinds of bacterial mixed agents has strong tolerance and decomposition effect, can secrete a variety of degradation enzymes, can play a good degradation effect on ...
Feb 05, 2025Open Access
This study was conducted to investigate the acute toxic effects of ciprofloxacin, norfloxacin and florfenicol, which are widely used antibacterial drugs, on loach. Through a well-planned experimental design, we systematically monitored the physiological and behavioral characteristics of loach under different drug concentrations and exposure time, and evaluated the toxic effects of these drugs. Under specific test conditions, i.e. water temperature is maintained at (10.0 ± 2.0)℃, and the pH value...
Jan 08, 2025Open Access
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...
Jul 31, 2024Open Access
In this study, gel-immobilized fillers were used to conduct partial nitrification experiments, including a small-scale experiment in the laboratory and a pilot experiment in a leather factory. The performance of the filler for partial nitrification was investigated by the small-scale experiment under the reactor start-up condition with low initial ammonia oxidizing bacteria (AOB) relative abundance. Then pilot experiment was carried out for the application of the filler in leather wastewater tre...
Jul 25, 2024Open Access
Smartphone-based Oximetry device as early healthcare detection is a technological frontier. Smartphone oximetry devices offer a convenient method for remote SpO 2 monitoring and early detection of critical health issues, especially during pandemics when vital indicators are necessary. Rising healthcare demands, and the COVID-19 pandemic are recent causes necessitating the prevalence for accessible early detection tools. This research investigates smartphone oximetry device as a conveni...
May 10, 2024Open Access
Citrobacter are Gram-negative bacteria that give public health challenges due to their zoonotic infections. Diarrheal diseases and antimicrobial resistance are global concerns that increase the burden of implementing infectious disease monitoring, especially in poor economic countries. This study was conducted to determine the prevalence and antimicrobial susceptibility and assess the risk factors of diarrheal diseases caused by bacteria from drinking water wells in the Urban West Regio...
Oct 31, 2023Open Access
Malaria is a parasitic disease caused by the protozoan parasites Plasmodium species, and usually transmitted through the bite of a female Anopheles species mosquito. Plasmodium falciparum is regarded as the most lethal of the Plasmodium species and most efforts are geared towards its control. Hitherto, with no available vaccines, an antimalarial drug such as Chloroquine was the main stay in the clinical management of uncomplicated P. falciparum malari...
Aug 18, 2023Open Access
The application of biotechnology in drug discovery has been discovered to be a promising and resourceful approach for the discovery of novel therapeutic candidates that comes with less time and cost than the traditional ways of drug discovery. This has additionally endowed researchers with the necessary understanding of diseases, which offers exceptional methods for treating patients. Additionally, diagnosis and treatment are becoming increasingly intertwined with the help of biotechnology. Toda...
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