OALib Journal
  OALib Journal is an all-in-one open access journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721). It accepts a manuscript for the peer-review processing, typesetting, publication and then allocated to one of the 322 subject areas. The article processing charge for publishing in OALib journal is Only $99. For more details, please contact service@oalib.com. Submit now
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Jan 31, 2023Open    AccessArticle

Drug Resistance in Malaria Parasites: Does “Specific Antidrug Substance” Exist?

Gao-De Li
Development of drug-resistant lines in rodent malaria parasites left us a deep impression on antidrug specificity of antimalarial drug-resistant lines, which is similar to antigen-induced antibody. Based on this comparison, “specific antidrug substance” was proposed to explain antidrug specificity of drug-resistant lines. If “specific antidrug substance” refers to a protein that is quite like antibody, the concept of “specific antidrug substance” is wrong because no such protein has been discove...
Open Access Library J.   Vol.10, 2023

Nov 17, 2022Open    AccessArticle

Atypical Shu (PTT) Induced by Chronic Drinking of Cocaine: A Case

Alpha Boubacar Bah, Flahaut Gauthier, Mamadou Saliou Balde, Mamadou Cellou Balde, Gabriel Choukroun
The thrombocytopenia associated with cocaine consumption has been well documented]. Severe thrombocytopenia usually occurs within 3 weeks of intravenous or inhaled cocaine abuse. Microangiopathic hemolytic anemia (MHA) associated with cocaine is rare. We would like to report a case of cocaine-induced atypical hemolyticus uremic syndrome. Clinical Observation: this is a 29-year-old Causasian patient, followed in a psychiatric center under duress for 6 years for behavioral disorders, hallucination...
Open Access Library J.   Vol.9, 2022

Feb 28, 2022Open    AccessArticle

Study the Effect of Convolvulus arvensis on the Contraction of Isolated Vascular Smooth Muscle Fibers Portal Vein

Wael Al-Aghawani, Bassel Hussein
Background: Convolvulus arvensis L. (Convolvulaceae) possess several biological properties and has been used in the treatment of hepatic obstructions. The present study aimed to evaluate the relaxant effects of the alcoholic extract of C. arvensis on both spontaneous and phenylephrine-induced contraction of isolated rat portal vein. Materials and Methods: First, the effect of the extracts was examined on spontaneous rhythmic contraction of longitudinal-cut portal strips, the extract was added cu...
Open Access Library J.   Vol.9, 2022

Feb 22, 2021Open    AccessArticle

Dose Load during Orthopedic Procedures

Natasha Ivanova, Javor Ivanov, Marin Marinov, Miroslav Petrov
This article discusses the dose load of people working with a C-arm X-ray system during orthopedic procedures. We measured the effective doses received by the doctor-operator and his assistant at three points of the body—head, gonads and feet, in radiography mode (single shot) and in three sub-modes of the fluoroscopy mode—continuous fluoroscopy; 1/2 dose fluoroscopy and pulse fluoroscopy. Calculations were made for dose rate the resulting our measurements due to the fact that at the different e...
Open Access Library J.   Vol.8, 2021

Nov 27, 2020Open    AccessArticle

Non-Clinical Factors Associated with International Normalized Ratio Control in Patients on Warfarin Therapy: A Review Paper

Tharani Ramasamy, Naganathan Kathiresan Pillai, Christina Gertrude Yap, Nowrozy Kamar Jahan
Warfarin is a coumarin derivative oral anticoagulant with a narrow therapeutic international normalized ratio (INR) range. Regular and accurate INR monitoring is essential for optimal anticoagulation management and to reduce the risk of adverse events. However, achieving and maintaining the therapeutic INR range are still a challenge as it is affected by several clinical and non-clinical factors. In this review paper, we analyzed how the non-clinical factors like socio-demographic, modifiable ri...
Open Access Library J.   Vol.7, 2020

Jul 08, 2020Open    AccessArticle

Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19

Gao-De Li
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
Open Access Library J.   Vol.7, 2020

May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Open Access Library J.   Vol.7, 2020

Sep 26, 2019Open    AccessArticle

Pharmacognostical Study of the Fruit Peels of Punica granatum

Rofidah Yasen Ahmed Diab, Ahlam Salih Eltahir
This study deals with Punica granatum fruit peels. This plant was selected because of its popularity and being highly used; it was purchased from herbarium markets of Khartoum Sudan. The study is divided into two parts, the
Open Access Library J.   Vol.6, 2019

Mar 27, 2019Open    AccessArticle

Pharmacognostic, Physicochemical and Phytochemical Analysis of Fruits of Talipariti elatum (Sw.) in Cuba

José González, Julio Pérez, Armando Cuéllar, Enrique Gómez, Yamilet I. Gutiérrez, Ramón Scull, Damaris de la C. Salgado, Max Monan
Talipariti elatum (Sw.) Fryxell is an endemic tree from Cuba, also known as “Majagua”, and has traditionally been used to improve asthmatic crisis and flu, as expectorant, appetitive, emollient, sudorific and laxative. Used as ornamental in park and avenues, its wood is used to make furnitures and baseball baths. In order to offer aspects related to the quality and effectiveness of the plant, its pharmacognostic, physicochemical,
Open Access Library J.   Vol.6, 2019

Dec 29, 2018Open    AccessArticle

Antimicrobial Activities of Syzygium aromaticum (L.) Merr. and L.M. Perry (Myrtaceae) Fruit Extracts on Six Standard Microorganisms and Their Clinical Counterpart

Y.-G. Afanyibo, K. Anani, K. Esseh, Y. Sadji, K. Idoh, K. Koudouvo, A. Agbonon, Y. Améyapoh, K. Tozo, M. Gbeassor
Syzygium aromaticum is used in combination with other plants as an al-coholic infusion by traditional practitioners to treat infections. It has been selected for evaluation for its antimicrobial properties to justify its use in traditional pharmacopoeia. The fruits were used as plant material while the microbial germs consisted of six reference strains: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Salmonella typh
Open Access Library J.   Vol.5, 2018


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