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Open Journal of Medicinal Chemistry

ISSN Print: 2164-3121

ISSN Online: 2164-313X

主页: http://www.scirp.org/journal/ojmc

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In Silico Exploration of New Inhibitors of Protein Kinases Containing an N-Phenylbenzamide Linker: A Combination of Docking and Molecular Dynamics Modeling, Pharmacophore Modeling and Virtual Screening

Aliaksandr Faryna, Elena Kalinichenko

Evaluation of the Anti-Sickling Cell and Cytotoxic Activities of Polar Extracts of Terminalia avicennioides Root Bark Guill. & Perr. (Combretaceae)

Cheikh Sall, Ousmane Faye, Mamadou Soumboundou, Noura Bamba, Ramatoulaye Baldé, Malick Ndao, Serigne Modou Sylla, Medoune Mbaye, Naja Fatou Coly, Awa Ndong

Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers

Sommai Patitungkho, Kingkaew Patitungkho

Preparation and Characterization of Vitamin-D Incorporated Marshmallow

Muhammad Ajmal, Rubina Bibi, Rauf Imran, Muhammad Ahmed Bin Azher

Comprehensive Assessment of Anxiolytic Properties in 4-HPAA Derivatives: Bridging in Vivo Validation and Molecular Docking Analyses

Kawthar Alhussieni, Rami Ayoub, Jamal Jilani, Qais Jarrar, Othman Alhussinei, Vetriselvan Subramaniyan, Esra Nasraldin Khalil Sharafaldin, Harshini Muruganantham, Jureerat Kijsomporn, Ling Shing Wong

Assay Advancements: Exploring Varied Assays for Thyroid-Stimulating Hormone Measurement in Subclinical Hypothyroidism Diagnosis in Riyadh, Saudi Arabia

Qumasha Alobaid, Sumayah Aljenedil, Waleed Altamimi, Khalid Alsumaily

Physicochemical Properties and Biological Activities of Novel Hydrazonate Copper Complexes

Sommai Patitungkho, Kingkaew Patitungkho

Synthesis, SAR, and in Silico ADME Screening Studies of Some 9-Amino-3-Phenylacridone Derivatives as Topoisomerase II Inhibitors

Abiodun S. Oyedele, Toluwase H. Fatoki, Esha Dalvie, Neil Osheroff, Cosmas O. Okoro

New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells

Edward C. Lisic, Sarah N. Grossarth, Sarah B. Bowman, Jessica L. Hill, Michael W. Beck, Joseph E. Deweese, Xiaohua Jiang

Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols

Rubina Bibi, Amina Sadiq, Ehsan Ullah Mughal

Critical Evaluation of Melaleuca alternifolia : A Review of the Phytochemical Profile, Pharmacological Attributes and Medicinal Properties in the Botanical, Human and Global Perspectives

Ibrahim Kasujja

Design, Synthesis and Antibacterial Activity Evaluation of 4,5-Diphenyl-1H-Imidazoles Derivatives

Coulibaly Bamoro, Fante Bamba, Koffi Téki Dindet Steve-Evanes, Vallin Aurélie, Chagnault Vincent

Synthesis and Antibacterial Activities of New 2-(Benzylthio)pyrimidines and 2-(Benzimidazolylmethylthio)pyrimidines Derivatives

Achi Patrick-Armand, Coulibali Siomenan, Zon Doumade, Timotou Adéyolé, Bolou Eric, Touré Daouda, Sissouma Drissa, Adjou Ané

Anti-Melanogenesis Effect of Daniellic Acid Isolated from Daniellia oliveri (Rolfe) Hutch. & Dalziel (Leguminosae) Oleoresin of Burkina Faso

Aminata P. Nacoulma, Moussa Compaoré, Naamwin-so-Bawfu Romaric Meda, Laurent Pottier, Véronique Megalizzi, Issa Some, Martin Kiendrebeogo

Anti-Cancer Activity and Molecular Docking of Some Pyrano[3,2‑c]quinoline Analogues

Abdeltawab M. Saeed, Ibrahim M. Abdou, Alaa A. Salem, Mohammad A. Ghattas, Noor Atatreh, Shaikha S. AlNeyadi

Targeting PPARγ Receptor Using New Phosphazene Derivative Containing Thiazolidinedione: Design, Synthesis, and Glucose Uptake

Shaikha S. Al Neyadi, Abdu Adem, Naheed Amir, Ibrahim M. Abdou

Design, Synthesis, in Vitro Antibacterial Activity, and Docking Studies of New Rhodanine Derivatives

Aisha Abusetta, Jowhara Alumairi, Mariam Y. Alkaabi, Ruba Al Ajeil, Asma Abu Shkaidim, Dana Akram, J. Pajak, Mohammad A. Ghattas, Noor Atatreh, Shaikha S. AlNeyadi

Abemaciclib, a Recent Novel FDA-Approved Small Molecule Inhibiting Cyclin-Dependant Kinase 4/6 for the Treatment of Metastatic Breast Cancer: A Mini-Review

Lou Anna Voli, Janat A. Mamyrbékova, Jean-Pierre Bazureau

Synthesis and Characterization of Kalata B2 Cyclotide (GLPVCGETCFGGTCNTPGCSCTWPICTRD) on Wang Resin, as Solid Support

Verma Deepshikha, Pillai V. N. Rajasekharan

Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides

Ouattara Mahama, Coulibaly Songuigama, N’Guessan Deto Jean-Paul

Anticancer Activities and QSAR Study of Novel Agents with a Chemical Profile of Benzimidazolyl-Retrochalcone

Ouattara Mahama, Koné Aboudramane, Koné Soleymane, Collet Sylvain, Diomandé Sekou, Sissouma Drissa

Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts

María M. Blanco, María A. Reamírez, María C. Caterina, Isabel A. Perillo, Guido A. Oppezzo, María S. Shmidt, Gabriel O. Gutkind, José Di Conza, Alejandra Salerno

Recent Advances in the Quest for Treatment and Management of Alzheimer and Other Dementia

Sameena E. Tanwir, Ajay Kumar

Synthesis and Antiproliferative Activities of Triphenylmethanol Conjugates of Leuprorelin

Ryan Beni, William Boadi, Kaleh Karim, Jawzah Alnakhli, Samiyah Alhamed

Triphenylmethanol Conjugates of Triptorelin as Anti-Lipid Peroxidation Prodrugs

Samiyah Alhamed, Jawzah Alnakhli, William Boadi, Ryan Beni

Investigatory Study of Long Term Doses of Costus afer, Snail Slime, and Their Combination with a Standard Pharmaceutical Drug on Blood Glucose Level of Alloxan Induced Swiss Albino Rat

Matthew Onyema Agu, Barminas Jeff Tsware, A. Osemeahon Sunday, Jude Chinedu Onwuka, Hotton Joseph Anthony

Determination of Azacitidine by Spectrophotometric Method

B. Ramachandra, N. Venkatasubba Naidu

Synthesis and Antimicrobial Activity of New Pyridine Containing Substituted Phenyl Azetidine-2-One Derivatives

V. Esther Rani, P. Raveendra Reddy

Cu(II) Propionyl-Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells

Edward C. Lisic, Victoria G. Rand, Lana Ngo, Patrick Kent, Jeffrey Rice, Deidra Gerlach, Elizabeth T. Papish, Xiaohua Jiang

Computational Study on the Comparative Differences in the Activity of Inhibitors of Human versus Rat Alpha-Glucosidase

Shinya Nakamura, Kazuko Shimada, Genzoh Tanabe, Osamu Muraoka, Isao Nakanishi

Synthesis and Evaluation of Folate-Conjugated Phenanthraquinones for Tumor-Targeted Oxidative Chemotherapy

Ajay Kumar, Venkatesh Chelvam, Mahalingam Sakkarapalayam, Guo Li, Pedro Sanchez-Cruz, Natasha S. Pi？ero, Philip S. Low, Antonio E. Alegria

A Review of Structure Activity Relationship of Amiodarone and Its Derivatives

Moiz A. Siddiqui, Amjad Khan, Mehreen Zaka

Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors

Jinxi Liao, Huimin Cheng, Junting Wan, Panyu Chen, Yingjun Li, Ke Ding, Micky D. Tortorella, Zhengchao Tu, Yanmei Zhang

Synthesis and Anti-Cancer Activities of Resveratrol Derivatives

Xing Zheng, Liuying Yu, Xu Yao, Bo Lv, Zehua Yang, Qutong Zheng, Haiying Duan, Chen Song, Hailong Xie

Synthesis and Evaluation of Antituberculosis Activity of Substituted 2,7-Dimethylimidazo [1,2-a]Pyridine-3-Carboxamide Derivatives

Bhagwat Jadhav, R. Kenny, Y. Nivid, Mustapha Mandewale, Ramesh Yamgar

Synthesis of Novel Acid Dyes with Coumarin Moiety and Their Utilization for Dyeing Wool and Silk Fabrics

Mahmoud S. Bashandy, Fatma A. Mohamed, Mohamed M. El-Molla, Mahmoud B. Sheier, Ahmed H. Bedair

A Peptide Nucleic Acid to Reduce Type I Collagen Production by Fibroblast Cells

Yasutada Imamura, Suzuka Tsuboi, Toru Sugiyama, Atsushi Kittaka, Yonchol Shin

Novel Cytocidal Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl) Benzenesulfonates and Benzenesulfonamides with Affinity to the Colchicine-Binding Site: Is the Phenyl 2-Imidazolidinone Moiety a New Haptophore for the Design of New Antimitotics?

Sébastien Fortin, Lianhu Wei, Lakshmi P. Kotra, René C.-Gaudreault

Synthesis and Bioactivity of Natural Occurring Petasin-Like Derivatives as Antitumor Agents

Xiaolong Shi, Saiyang Zhang, Jianghao Wang, Tingyu Li, Junju Liu, Yi Hou, Lei Liu, Dongjun Fu, Haiwei Xu, Hongmin Hongmin, Yanbing Zhang

Synthesis, Spectral, Anti-Liver Cancer and Free Radical Scavenging Activity of New Azabicyclic Thienoyl Hydrazone Derivatives

M. Manimaran, A. Ganapathi, T. Balasankar

Synthesis of Pyrroles and Condensed Pyrroles as Anti-Inflammatory Agents with Multiple Activities and Their Molecular Docking Study

M. T. Sarg, M. M. Koraa, A. H. Bayoumi, S. M. Abd El Gilil

Synthetic Resveratrol Derivatives and Their Biological Activities: A Review

Ya Liu, Yi Liu, Hongfei Chen, Xu Yao, Yan Xiao, Xianliang Zeng, Qutong Zheng, Yun Wei, Chen Song, Yinxiang Zhang, Peng Zhu, Juan Wang, Xing Zheng

In Silico Pharmacokinetics Studies for Quinazolines Proposed as EGFR Inhibitors

Gabriela Souza Fernandes, Michelle Bueno de Moura Pereira, Ana Cláudia Barbosa Marinho, Brisa Machado, Ana Carla Moreira, Matheus Puggina de Freitas, Karen Luise Lang, Jo？o Eustáquio Antunes

Experience of Using the Recombinant Human Superoxide Dismutase Drug in Neurological and Ophthalmological Practice

Elena E. Dubinina, Irina V. Churilova, Liudmila V. Lipatova, Liudmila V. Zhuravleva

Resveratrol Reverses the Impaired Vasodilation Observed in 2K-1C Hypertension through Endothelial Function Improvement

B. F. M. Pereira, A. C. Scalabrini, T. S. Marinho, C. R. K. Antonietto, C. B. A. Restini

Utility of 2-Methyl-quinazolin-4(3H)-one in the Synthesis of Heterocyclic Compounds with Anticancer Activity

Aisha Youssif Hassan Helali, Marwa Taha Mostafa Sarg, Makarem Mohamed Said Koraa, Mona Said Fathy El-Zoghbi

Efficient Utilization of 6-Aminouracil to Synthesize Fused and Related Heterocyclic Compounds and Their Evaluation as Prostate Cytotoxic Agents with Cathepsin B Inhibition

Marwa Taha Mostafa Sarg, Shereen Said El-Shaer

Biological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells

Christian Vélez, Beatriz Zayas, Ajay Kumar

Effects of Ranolazine on Carbohydrate Metabolism in the Isolated Perfused Rat Liver

Márcio Shigeaki Mito, Cristiane Vizioli de Castro, Rosane Marina Peralta, Adelar Bracht

Design and Molecular Docking Study of Antimycin A3 Analogues as Inhibitors of Anti-Apoptotic Bcl-2 of Breast Cancer

Ade Arsianti,   Fadilah,   Kusmardi, Hiroki Tanimoto, Tsumoru Morimoto, Kiyomi Kakiuchi

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