A series of 4-thioflavonols compounds were synthesized by treating
flavonols with lawsons reagent with variable substituent groups at A, B, and AB
rings. All the synthesized compounds were
checked for antibacterial and antifungal activity. We report that many
compounds were found active against Escherichiacoli, Pseudomonasaeruginosa, Staphylococcusaureus, Methicillin-resistantStaphylococcusaureus, bacterial strains and, C. albicans,C. parapsilosisstrains and C.krusei fungal strains. Most of the synthesized 4-thioflavonols compounds were found to show enhanced antimicrobial activity than
respective flavonol compounds.
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