%0 Journal Article
%T The Predictive Role of LncRNA Molecules (HOTAIR) in Breast Cancer Prognosis
%A Faisal Redwan
%A Nader Abdullaa
%A Eyad Alshatti
%A Ansam Abdullah
%J Open Access Library Journal
%V 12
%N 4
%P 1-8
%@ 2333-9721
%D 2025
%I Open Access Library
%R 10.4236/oalib.1112993
%X <strong>Objective</strong>: The aim of the present study is to assess the role of the level of change in gene expression of the HOTAIR molecule in breast cancer patients. <strong>Methods</strong>: An assay was conducted for the level of gene expression of the HOTAIR molecule in the plasma of 30 patients and 10 healthy controls, by performing the reverse transcription reaction RT-qPCR, gene expression was evaluated using the Livak equation, tumor characteristics (grade, HER2 receptors, hormonal (HR) receptors) were also studied in the Pathological Anatomy Department and compared between patients. <strong>Results</strong>: The results of the study showed that there was a significant difference (P £¼ 0.05) in the level of change in gene expression between the patients and controls. There was a correlation between the level of change in gene expression and tumor grade, positivity for HER2 receptors and negativity for HR receptors. <strong>Conclusion</strong>: It was found that the gene expression level of HOTAIR molecule may have a prognostic significance in the diagnosis of breast cancer and the characteristics of the tumor responsible for increasing tumor virulence and poor prognosis.<br />
%K Breast Cancer
%K HOTAIR
%K Tumor Grade
%K HER2 Receptor
%K HR Receptors
%U http://www.oalib.com/paper/6851425