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Drug Resistance in Malaria Parasites: Does “Specific Antidrug Substance” Exist?

DOI: 10.4236/oalib.1109691, PP. 1-6

Subject Areas: Pharmacology, Drugs & Devices

Keywords: Molecular Pharmacology, Drug Resistance in Malaria Parasite, “Specific Antidrug Substance”, 3D Genome Architecture, “Specific Antidrug Group of Protein Combinations”

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Development of drug-resistant lines in rodent malaria parasites left us a deep impression on antidrug specificity of antimalarial drug-resistant lines, which is similar to antigen-induced antibody. Based on this comparison, “specific antidrug substance” was proposed to explain antidrug specificity of drug-resistant lines. If “specific antidrug substance” refers to a protein that is quite like antibody, the concept of “specific antidrug substance” is wrong because no such protein has been discovered. However, if “specific antidrug substance” refers to a “specific antidrug group of protein combinations”, the concept of “specific antidrug substance” might be true. A detailed explanation of “specific antidrug substance” is presented in this paper.

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Li, G. (2023). Drug Resistance in Malaria Parasites: Does “Specific Antidrug Substance” Exist?. Open Access Library Journal, 10, e9691. doi:


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