Development of drug-resistant lines in rodent malaria parasites left us a deep impression on antidrug specificity of antimalarial drug-resistant lines, which is similar to antigen-induced antibody. Based on this comparison, “specific antidrug substance” was proposed to explain antidrug specificity of drug-resistant lines. If “specific antidrug substance” refers to a protein that is quite like antibody, the concept of “specific antidrug substance” is wrong because no such protein has been discovered. However, if “specific antidrug substance” refers to a “specific antidrug group of protein combinations”, the concept of “specific antidrug substance” might be true. A detailed explanation of “specific antidrug substance” is presented in this paper.
Cite this paper
Li, G. (2023). Drug Resistance in Malaria Parasites: Does “Specific Antidrug Substance” Exist?. Open Access Library Journal, 10, e9691. doi: http://dx.doi.org/10.4236/oalib.1109691.
Hastings, I.M. and Felger, I. (2022) WHO Antimalarial Trial Guidelines: Good Science, Bad News? Trends in Parasitology, 38, 933-941.
https://doi.org/10.1016/j.pt.2022.08.005
Dhorda, M., Amaratunga, C. and Dondorp, A.M. (2021) Artemisinin and Multidrug-Resistant Plasmodium falciparum—A Threat for Malaria Control and Elimination. Current Opinion in Infectious Diseases, 34, 432-439.
https://doi.org/10.1097/QCO.0000000000000766
Plowe, C.V. (2022) Malaria Chemoprevention and Drug Resistance: A Revoie of the Literature and Policy Implications. Malaria Journal, 21, 104.
https://doi.org/10.1186/s12936-022-04115-8
Li, G.D., Qu, F.Y. and Chen, L. (1985) Development of Piperaquine-Resistant Line of Plasmodium berghei ANKA Strain. Chinese Journal of Parasitology & Parasitic Diseases, 3, 189-192. (In Chinese)
Li, G.D., Qian, Y.L. and Chen, L. (1989) Antagonism of Serum of Mice Infected with Chloroquine-Resistant “NS” Line to the Antimalarial Action of Chloroquine. Acta pharmacologica Sinica, 10, 257-260.
Lanctôt, C., Cheutin, T., Cremer, M. et al. (2007) Dynamic Genome Architecture in the Nuclear Space: Regulation of Gene Expression in Three Dimensions. Nature Reviews Genetics, 8, 104-115. https://doi.org/10.1038/nrg2041
Bonora, G., Plath, K. and Denholtz, M. (2014) A Mechanistic Link between Gene Regulation and Genome Architecture in Mammalian Development. Current Opinion in Genetics & Development, 27, 92-101.
https://doi.org/10.1016/j.gde.2014.05.002
Belokopytova, P. and Fishman, V. (2021) Predicting Genome Architecture: Challenges and Solutions. Frontiers in Genetics, 11, Article ID: 617202.
https://doi.org/10.3389/fgene.2020.617202
Li, G. D. (2020) Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions. Open Access Library Journal, 7, 1-9. https://doi.org/10.4236/oalib.1106340
Li, G.D. (2019) Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure. Open Access Library Journal, 6, e5531. https://doi.org/10.4236/oalib.1105531
