Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (PPP) which reduces NADP to NADPH while oxidizing glucose-6-phosphate. NADPH subsequently acts as a reducing agent, allowing oxidized glutathione to be converted to reduced glutathione, which protects against oxidant damage. Objectives: This study aimed to assess G6PD activity in Sudanese diabetic patients and its relationship with hyperglycemia. Materials and Methods: This study was a case control study done during the period from 2015 to 2018. Included 245 diabetic patients, compared to 245 age matching adults non-diabetic as control, male and female. Erythrocyte G6PD activity was determined using a quantitative spectrophotometric assay of enzyme by commercial kit. Blood glucose was conducted using a spectrophotometric procedure by Glucose Oxidase/Peroxidase test. Results: The study proved that, the incidences of low activity of G6PD enzyme among diabetic patients were 21.6%, and there was no evidence of deficiency or low activity in controls P. value (0.000). According to G6PD activity normal value, 53 (21.6%) were low activity and 192 (78.4%) were normal activity, and there was no complete deficiency at all in studied population. The relation between G6PD activity and high blood glucose level revealed a highly significant difference with P. value (0.006). Conclusions: The study concluded that G6PD low activity is one of the risk factors for diabetes mellitus, as well as hyperglycemia.
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Ahmed, A. K. , Elsiddig, Y. M. , Mohamedahmed, K. A. , Gamar, S. Y. , Mohammed, Y. A. , Alfaham, Z. H. , Saeed, O. K. A. and Abbas, A. A. (2022). Assessment of G6PD Activity among Diabetic Patients and Its Relationship with Hyperglycemia, Wad Madani, Gezira State, Sudan. Open Access Library Journal, 9, e9399. doi: http://dx.doi.org/10.4236/oalib.1109399.
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