%0 Journal Article
%T Assessment of G6PD Activity among Diabetic Patients and Its Relationship with Hyperglycemia, Wad Madani, Gezira State, Sudan
%A Afraa Kamil Ahmed
%A Yosria Mohammed Elsiddig
%A Khalid Abdelsamea Mohamedahmed
%A Sami Yousif Gamar
%A Yousif Abdelhameed Mohammed
%A Zeinab H. Alfaham
%A Osman Khalaf Alla Saeed
%A Asad Adam Abbas
%J Open Access Library Journal
%V 9
%N 11
%P 1-9
%@ 2333-9721
%D 2022
%I Open Access Library
%R 10.4236/oalib.1109399
%X Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (PPP) which reduces NADP to NADPH while oxidizing glucose-6-phosphate. NADPH subsequently acts as a reducing agent, allowing oxidized glutathione to be converted to reduced glutathione, which protects against oxidant damage. Objectives: This study aimed to assess G6PD activity in Sudanese diabetic patients and its relationship with hyperglycemia. Materials and Methods: This study was a case control study done during the period from 2015 to 2018. Included 245 diabetic patients, compared to 245 age matching adults non-diabetic as control, male and female. Erythrocyte G6PD activity was determined using a quantitative spectrophotometric assay of enzyme by commercial kit. Blood glucose was conducted using a spectrophotometric procedure by Glucose Oxidase/Peroxidase test. Results: The study proved that, the incidences of low activity of G6PD enzyme among diabetic patients were 21.6%, and there was no evidence of deficiency or low activity in controls P. value (0.000). According to G6PD activity normal value, 53 (21.6%) were low activity and 192 (78.4%) were normal activity, and there was no complete deficiency at all in studied population. The relation between G6PD activity and high blood glucose level revealed a highly significant difference with P. value (0.006). Conclusions: The study concluded that G6PD low activity is one of the risk factors for diabetes mellitus, as well as hyperglycemia.
%K Glucose 6 Phosphate Dehydrogenase
%K Diabetes Mellitus
%K Hyperglycemia
%U http://www.oalib.com/paper/6783322