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Does the Location and Prevelance of Gastric Intestinal Metaplasia Change in Patients with Functional Dyspepsia

DOI: 10.4236/oalib.1107982, PP. 1-9

Subject Areas: Biochemistry

Keywords: Gastric Intestinal Metaplasia, Helicobacter Pylori, Gastritis, Functional Dispepsia

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Abstract

Gastric intestinal metaplasia plays a significant role in the pathogenesis of intestinal gastric cancer. Objective: A retrospective analysis of demographic characteristics, site of involvement, and incidence was performed involving patients who underwent endoscopy who had biopsy-diagnosed intestinal metaplasia. Materials and Methods: The study included 720 patients with functional dyspepsia retrospectively from among 6160 patients who underwent upper endoscopy in Celal Bayar University, Faculty of Medicine, Gastroenterology Department, between 2014 and 2020. Results: Intestinal metaplasia was detected at the antrum, corpus, and angulus in 59.94%, 13.47%, and 28.57% of the cases, respectively. Antral lesions were significantly more prevalent (P < 0.05). Of the patients with IM, 63.5% had HP positivity, with a significant association between IM positivity and HP positivity (P < 0.05). There was a significant difference between patients with or without a history of chronic PPI use in terms of the prevalence of intestinal metaplasia (P < 0.05). Conclusion: These results suggest that the endoscopic follow-up of patients with IM requires additional attention to the lesser curvature of the antrum as well as the gastric angulus.

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Buran, T. , Kasap, E. and Ayhan, S. (2021). Does the Location and Prevelance of Gastric Intestinal Metaplasia Change in Patients with Functional Dyspepsia. Open Access Library Journal, 8, e7982. doi: http://dx.doi.org/10.4236/oalib.1107982.

References

[1]  Ferlay, J., Soerjomataram, I., Dikshit, R., et al. (2015) Cancer Incidence and Mortality Worldwide: Sources, Methods, and Major Patterns in GLOBOCAN 2012. International Journal of Cancer, 136, E359-E386. https://doi.org/10.1002/ijc.29210
[2]  Correa, P. (1992) Human Gastric Carcinogenesis: A Multistep and Multifactorial Process—First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Research, 52, 6735-6740.
[3]  Mao, X.Y., Xu, S.F., Liu, Q., et al. (2016) Anatomical Predilection of Intestinal Metaplasia Based on 78,335 Endoscopic Cases. Saudi Journal of Gastroenterology, 22, 154-160.
[4]  Gomez, J.M. and Wang, A.Y. (2014) Gastric Intestinal Metaplasia and Early Gastric Cancer in the West: A Changing Paradigm. Gastroenterology & Hepatology, 10, 369-378.
[5]  Nunes, P.P., Libanio, D., Pinto, R.M., et al. (2019) Management of Epithelial Precancerous Conditions and Lesions in the Stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) Guideline Update 2019. Endoscopy, 51, 365-388. https://doi.org/10.1055/a-0859-1883
[6]  Fukase, K., Kato, M., Kikuchi, S., et al. (2008) Effect of Eradication of Helicobacter pylori on the Incidence of Metachronous Gastric Carcinoma after Endoscopic Resection of Early Gastric Cancer: An Open-Label, Randomised Controlled Trial. The Lancet, 372, 392-397. https://doi.org/10.1016/S0140-6736(08)61159-9
[7]  Kong, Y.J., Yi, H.G., Dai, J.C., et al. (2014) Histological Changes of Gastric Mucosa after Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis. World Journal of Gastroenterology, 20, 5903-5911. https://doi.org/10.3748/wjg.v20.i19.5903
[8]  Waldum, H.L. and Fossmark, R. (2018) Types of Gastric Carcinomas. International Journal of Molecular Sciences, 19, Article No. 4109. https://doi.org/10.3390/ijms19124109
[9]  Cheung, K.S., Chan, E.W., Wong, A.Y.S., et al. (2018) Long-Term Proton Pump Inhibitors and Risk of Gastric Cancer Development after Treatment for Helicobacter pylori: A Population-Based Study. Gut, 67, 28-35. https://doi.org/10.1136/gutjnl-2017-314605
[10]  Niikura, R., Hayakawa, Y., Hirata, Y., et al. (2018) Long-Term Proton Pump Inhibitor Use Is a Risk Factor of Gastric Cancer after Treatment for Helicobacter pylori: Retrospective Cohort Analysis. Gut, 67, 1908-1910. https://doi.org/10.1136/gutjnl-2017-315710
[11]  Bray, F., Ferlay, J., Soerjomataram, I., et al. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. https://doi.org/10.3322/caac.21492
[12]  Craanen, M.E., Blok, P., Dekker, W., et al. (1992) Subtypes of Intestinal Metaplasia and Helicobacter pylori. Gut, 33, 597-600. https://doi.org/10.1136/gut.33.5.597
[13]  Fraser, A.G., Peng, S. and Jass, J.R. (1998) Intestinal Metaplasia Subtypes and Helicobacter pylori Infection. A Comparison of Ethnic Groups in New Zealand. Journal of Gastroenterology and Hepatology, 13, 560-565. https://doi.org/10.1111/j.1440-1746.1998.tb00690.x
[14]  Fontham, E.T., Ruiz, B., Perez, A., Hunter, F., et al. (1995) Determinants of Helicobacter pylori Infection and Chronic Gastritis. American Journal of Gastroenterology, 90, 1094-1101.
[15]  Craanen, D.W., Blok, P., Ferwerda, J., et al. (1992) Intestinal Metaplasia and Helicobacter pylori: An Endoscopic Bioptic Study of the Gastric Antrum. Gut, 33, 6-20. https://doi.org/10.1136/gut.33.1.16
[16]  Genta, R.M. and Sonnenberg, A. (2015) Characteristics of the Gastric Mucosa in Patients with Intestinal Metaplasia. The American Journal of Surgical Pathology, 39, 700-704. https://doi.org/10.1097/PAS.0000000000000384
[17]  Imai, Y., Kobayashi, I., Ishida, S., et al. (2013) Antral Recirculation in the Stomach during Gastric Mixing. American Journal of Physiology: Gastrointestinal and Liver Physiology, 304, G536-G542. https://doi.org/10.1152/ajpgi.00350.2012
[18]  Erikssona, N.K., Kärkkäinenb, P.A., Färkkiläa, M.A., et al. (2008) Prevalence and Distribution of Gastric Intestinal Metaplasia and Its Subtypes. Digestive and Liver Disease, 40, 355-360.
[19]  Niikura, R., Hayakawa, Y., Hirata, Y., et al. (2019) The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion. International Journal of Molecular Sciences, 20, Article No. 913. https://doi.org/10.3390/ijms20081913
[20]  Annibale, B., Di Giulio, E., Caruana, P., et al. (2002) The Long-Term Effects of Cure of Helicobacter pylori Infection on Patients with Atrophic Body Gastritis. Alimentary Pharmacology & Therapeutics, 16, 1723-1731. https://doi.org/10.1046/j.1365-2036.2002.01336.x
[21]  Chen, D., Zhao, C.M., Dockray, G.J., et al. (2000) Glycine-Extended Gastrin Synergizes with Gastrin 17 to Stimulate Acid Secretion in Gastrin-Deficient Mice. Gastroenterology, 119, 756-765. https://doi.org/10.1053/gast.2000.16480
[22]  Kuipers, E.J., Uyterlinde, A.M., Pena, A.S., et al. (1995) Increase of Helicobacter pylori-Associated Corpus Gastritis during Acid Suppressive Therapy: Implications for Long-Term Safety. American Journal of Gastroenterology, 90, 1401-1406.

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