The focus of this investigation was to prepare the cocrystal of carbamazepine (CBZ) using nicotinamide as a coformer and to compare its different preparation methods. The cocrystal was prepared by grinding, solvent-Assisted grinding and ultrasound-assisted cocrystallization methods. They were characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and morphology by electron microscopy. In conclusion, ultrasound can be applied as a process intensification parameter along with cooling or slurry cocrystallization to produce pure cocrystals under conditions that might result in crystal mixtures in conventional processes.
Cite this paper
Ying, H. , Zhang, J. and Jiang, C. (2021). Preparation of Carbamazepine-Nicotinamide Cocrystal. Open Access Library Journal, 8, e7605. doi: http://dx.doi.org/10.4236/oalib.1107605.
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