%0 Journal Article
%T Preparation of Carbamazepine-Nicotinamide Cocrystal
%A Huirong Ying
%A Jinna Zhang
%A Chengjun Jiang
%J Open Access Library Journal
%V 8
%N 7
%P 1-8
%@ 2333-9721
%D 2021
%I Open Access Library
%R 10.4236/oalib.1107605
%X The focus of this investigation was to prepare the cocrystal of carbamazepine (CBZ) using nicotinamide as a coformer and to compare its different preparation methods. The cocrystal was prepared by grinding, solvent-Assisted grinding and ultrasound-assisted cocrystallization methods. They were characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and morphology by electron microscopy. In conclusion, ultrasound can be applied as a process intensification parameter along with cooling or slurry cocrystallization to produce pure cocrystals under conditions that might result in crystal mixtures in conventional processes.
%K Carbamazepine
%K Nicotinamide
%K Cocrystal
%K Ultrasound
%U http://www.oalib.com/paper/6758077