%0 Journal Article
%T Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety
%A Samir B. Salib
%A Omneya M. Khalil
%A Mona M. Kamel
%A Yara El-Dash
%J Open Access Library Journal
%V 3
%N 7
%P 1-7
%@ 2333-9721
%D 2016
%I Open Access Library
%R 10.4236/oalib.1102876
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3</span><i style="line-height:1.5;">H</i><span style="line-height:1.5;">)-5,6,7,8-tetrahydro[1]benzothieno[2,3-</span><i style="line-height:1.5;">d</i><span style="line-height:1.5;">]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been elucidated on the basis of
elemental analyses and spectroscopic methods (IR, </span><sup>1</sup><span style="line-height:1.5;">H-NMR, </span><sup>13</sup><span style="line-height:1.5;">C-NMR
and MS). The </span><i style="line-height:1.5;">in vitro</i><span style="line-height:1.5;"> cytotoxi</span><span style="line-height:1.5;">c activity of the synthesized derivatives
was evaluated against two human cell lines: prostate cancer (PC-3) and colon
cancer (HCT-116).</span> 
</div>
%K Synthesis
%K Thieno[2
%K 3-<i>d</i>]Pyrimidine
%K Thiosemicarbazides
%K Anticancer Agents
%U http://www.oalib.com/paper/5270615