We evaluated centrally acting analgesic potential using tail immersion
test and peripheral pharmacological actions using acetic acid induced writhing
test in rats. The crude extracts of Trema
guineensis leave plant were found to have significant analgesic activity at
the intraperitoneal dose of 200 mg/kg body weight in two models. In the tail
immersion test Trema guineensis increased significantly (P < 0.001) in comparison to the
control group (NaCl). The ethanolic (7.57 ± 0.14 s) and aqueous (8.88 ± 0.12 s)
extracts reached their maximum in reaction time successively at 30and
45 min. The aim of this study is also to determine the trace elements content
in suffering rats of pain induced by acetic acid, using Atomic Spectrophotometer
Absorption. Our results showed that trace element concentrations in Trema guineensis ethanolic extract in
rats were as follows: Zn (6.92 ± 0.39 mg/L), Fe (37.95 ± 0.04 μmol/L), Cu (8.16
± 0.12 mg/L) and Mn (0.56 ± 0.12 mg/L). We found following values with aqueous
extract compared to NaCl as control: Zn (5.03 ± 0.47 mg/L), Fe (31.08 ± 0.07
μmol/L), Cu (6.69 ± 0.53 mg/L) and Mn (0.51 ± 0.07 mg/L). The intake of trace
elements by TGE would lessen the pain generated in acetic acid in rats; this action
is much more remarkable with the ethanol extract.
Cite this paper
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