Atomic
absorption analysis involves measuring the absorption of light by vaporized
ground state atoms and relating the absorption to concentration. The incident
beam of light is attenuated by atomic vapour absorption according to Beer’s
Law. The estimation of trace elements shows a colorful presentation of
different metals. It has been seen and found that the levels of zinc, calcium,
magnesium, aluminum are lower in Alzheimer’s disease samples in comparison to
healthy controls. The elements such as copper, iron, potassium and sodium were
found higher than controls. A statistical analysis has been applied and
measured regression with correlation coefficients including multiple
correlation coefficients between different trace elements like Na, K, Ca, Mg,
Zn, Cu, Fe and Al in normal samples. A trend has been found in coefficient of
correlation such aswith positive correlation and with negative correlation. Coefficient of
partial correlation is also calculated and found that a trend has been set up
between trace elements and given here as with positive correlation and with negative correlation. Multiple correlation coefficient in normal
healthy person has been estimated and found that a trend, which is given here
as. Multiple
correlation coefficient in AD samples has been estimated and found that a
trend, which is given here as .
Cite this paper
Kumar, S. , Mittal, R. , Chaudhary, S. and Jain, D. C. (2014). Role of Trace Elements Alzheimer’s Disease. Open Access Library Journal, 1, e714. doi: http://dx.doi.org/10.4236/oalib.1100714.
Sambat, L. (1994) Historical Perspectives. In: Handy, R.C., Turnbull, J.M., Clark, W. and LanCaster, M.N., Eds., Alzheimer’s Disease. A Hand Book for Care Givers, 2nd Edition, Mosby-Year, Book, Inc., St. Louis, 51-59.
Whaley, N.S. (2002) Senility, Confusion, Debate Fear: Conceptualizing Alzheimer’s Disease and the History of Senile Dementia. Thesis, Drew University, Madison.
Harry, V. and Jenaro, F. (2003) Alzheimer’s Disease. In: Cummings, J.L. and Martin, D., Eds., Neuropsychiatry of Alzheimer’s Disease and Related Dementias, CRC Press, Boca Raton, 57-116.
Lindy, E.H., Daniel, M., Linda, D., Jane, F., Sheila, B., Anderson, B., Chaterjee, A. and Bartolucci, A. (1995) Behavioral Changes in Early Alzheimer’s Disease. In: Iqbal, K., Martimer, J.A., Winblad, B. and Wisniewski, H.M., Eds., Research Advances in Alzheimer’s Disease and Related Disorders, John Wiley & Sons, Hoboken, 219-224.
Robins, P.V., Mace, N.L. and Lucas, M.J. (1982) The Impact of Dementia on the Family. JAMA, 248, 333-335. http://dx.doi.org/10.1001/jama.1982.03330030039022
Folstein, M. and Bylsma, F.W. (1994) Non Cognitive Symptoms of Alzheimer’s Disease. In: Terry, R., Katzman, R. and Beck, K.C., Eds., Alzheimer’s Disease, Raven Press, New York, 27-40.
Reisberg, B., Borenstein, J., Salob, S.P., Ferris, S.H., Franssen, E. and Georgotas, A. (1987) Behavioral Symptoms in Alzheimer’s Disease: Phenomenology and Treatment. Journal of Clinical Psychiatry, 48, 9-15.
Teri, L., Larson, E. and Reixer, B. (1988) Behavioral Disturbance in Dementia of the Alzheimer’s Type. Journal of the American Geriatrics Society, 36, 1-6.
Cummings, J.L. (1985) Organic Delusions Phenomenology, Anatomical Correlations and Review. The British Journal of Psychiatry, 146, 184-197. http://dx.doi.org/10.1192/bjp.146.2.184
Cummings, J.L., Miller, B., Hill, M.A. and Neshkes, R. (1987) Neuro-psychiatric Aspects of Multi-Infarct Dementia and Dementia of the Alzheimer’s Type. Archives of Neurology, 44, 389-393. http://dx.doi.org/10.1001/archneur.1987.00520160031010
Khachaturian, Z.S. (1987) Status of Alzheimer’s Disease Research. In: Altman, H.J., Ed., Alzheimer’s Disease Problems, Prospects and Perspectives, Springer, New York, 183-189.
Ranold, C.H. and Larry, B.H. (1994) Urinary and Fecal Incontinence. In: Handy, R.C., Turnbull, J.M., Clark, W. and Lancaster, M.N., Eds., Alzheimer’s Disease. A Hand Book for Care Givers, 2nd Edition, Mosby-Year, Book, Inc., St. Louis, 199-212.
Amaducci, L., Falcini, M. and Lippi, A. (1993) Descriptive Epidemiology for Risk Factors and Alz-heimer’s Disease. In: Corain, B., Iqbal, K., Nicolini, B., Winblad, H., Wisniewski and Zatta, P., Eds., Alzheimer’s: Advances in Clinical and Basis Research, John Wiley & Sons, Ltd., Hoboken, 105-111.
Nielsen, J. (1963) Geronotopsychiatric Period Presence Investigation in a Geographically Delimited Population. Acta Psychiatrica Scandinavica, 38, 307-330. http://dx.doi.org/10.1111/j.1600-0447.1962.tb01802.x
Jorm, A.F., Korten, A.E. and Henderson, A.S. (1987) The Prevalence of Dementia: A Quantative Investigation of the Literature. Acta Psychiatrica Scandinavica, 76, 465-479. http://dx.doi.org/10.1111/j.1600-0447.1987.tb02906.x
Ronald, C.H. and Lorry, B.H. (1994) Factors That Aggravate the Symptoms. In: Handy, R.C., Turnbull, J.M., Clark, W. and Lancaster, M.N., Eds., Alzheimer’s Disease. A Hand Book for Care Givers, 2nd Edition, Mosby-Year, Book, Inc., St. Louis, 104-116.
Ronald, C.H. (1994) Clinical Presentation. In: Handy, R.C., Turnbull, J.M., Clark, W. and Lancaster, M.N., Eds., Alzheimer’s Disease. A Hand Book for Care Givers, 2nd Edition, Mosby-Year, Book, Inc., St. Louis, 74-85.
Gauthier, S., Thal, L.J. and Rossor, M. (2001) The Future Diagnosis and Treatment of Alzheimer’s Disease. In: Gauthier, S., Ed., Clinical Diagnosis and Management of Alzheimer’s Disease, Martin Dunitz, London, 369-398.
Wells, C.E. (1983) Differential Diagnosis of Alzheimer’s Dementia: Affective Disorder. In: Reisberg, B., Ed., Clinical Diagnosis and Different Diagnosis of Alzheimer’s Disease, Free Press, New York, 193-197.
Cummings, J. and Khachaturian, Z.S. (1996) Definitions and Diagnostic Criteria. In: Gauthier, S., Ed., Clinical Diagnosis and Management of Alzheimer’s Disease, Dunitz, London, 3-31.
Howard, L.F. and Reid, B. (2002) Neurological Disorders of Increased Prevalence in Women Migraine, Multiple Sclerosis and Alzheimer’s Disease. In: Susan, G.K. and Clayton, A.H., Eds., A Comprehensive Text Book, The Guliford Press, New York, 467-480.
Cotman, C.W., Bridges, R., Pike, C., Kesslak, D.L. and Copani, A. (1993) Mechanism of Neuronal Cell Death in Alzheimer’s Disease. In: Corain, B., Iqbal, K., Nicolini, M., Winblad, B., Wisniewski, H. and Zatta, P., Eds., Alzheimer’s Disease: Advances in Clinical and Basic Research, John Wiley & Sons Ltd., Hoboken, 281-289.
Greig, N.H., et al. (2004) New Therapeutic Strategies and Drug Candidates for Neurodegenrative Disease: P53 and TNF-Alpha Inhibitors, and GLP-1 Receptor Agonists. Annals of the New York Academy of Sciences, 1035, 290-315. http://dx.doi.org/10.1196/annals.1332.018
Patterson, C., Feightner, J.W., Garcia, A.H., Sing, G.Y., Macknight, C. and Sadovnivk, A.D. (2008) Diagnosis and Treatment of Dementia: 1. Risk Assessment and Primary Prevention of Alzheimer’s Disease. Canadian Medical Association Journal, 178, 548-556. http://dx.doi.org/10.1503/cmaj.070796
Rosendorff, C., Beeri, M.S. and Silverman, J.M. (2007) Cordiovascular Risk Factors for Alzheimer’s Disease. The American Journal of Geriatric Cardiology, 16, 143-149. http://dx.doi.org/10.1111/j.1076-7460.2007.06696.x
Solfrizzi, V., et al. (2008) Life Style Related Factors in Predementia and Dementia Syndromes. Expert Review of Neurotherapeutics, 8, 133-158. http://dx.doi.org/10.1586/14737175.8.1.133
Panza, F., Capurso, C., D’Introno A., Colacicco, A.M., Frisardi, V., Lorusso, M., Santamato, A., Seripa, D., Pilotto, A., Scafato, E., Vendemiate, G., Capurse, A. and Solfrizzi, V. (2009) Alcohol Drinking, Cognitive Functions in Older Age, Predementia and Dementia Syndromes. Journal of Alzheimer’s Disease, 17, 7-31.
Rondeau, V., Commenges, D., Jaeqmin-Gadd, H. and Dartigues, J.-F. (2000) Relation between Aluminum Concentrations in Drinking Water and Alzheimer’s Disease: An 8-Year Follow-Up Study. American Journal of Epidemiology, 152, 59-66. http://dx.doi.org/10.1093/aje/152.1.59
Cataldo, J.K., Prochaska, J.J. and Glantz, S.A. (2010) Cigarette Smoking Is a Risk Factor for Alzheimer’s Disease: An Analysis Controlling for Tobacco Industry Affiliation. Journal of Alzheimer’s Disease, 19, 465-80.
Khachaturian, Z.S. and Radebaugh, T.S. (1996) Alzheimer’s Disease: Cause(s), Diagnostic Treatment, and Care. In: Boca. Ratan, F. L. and Kim, H., CRC Press, 239-247.
Geldmacher, D.S. (2007) Treatment Guidelines for Alzheimer’s Disease: Redefining Perception in Primary Care. Primary Care Companion to the Journal of Clinical Psychiatry, 9, 113-121.
Schmitt, F.A. and Wichems, C.H. (2006) A Systematic Review of Assessment and Treatment of Moderate to Severe Alzheimer’s Disease. Primary Care Companion to the Journal of Clinical Psychiatry, 8, 158-169. http://dx.doi.org/10.4088/PCC.v08n0306
Herring, W.B., Leavell, B.S., Paixao, L.M. and Yoe, J.H. (1960) Trace Metals in Human Plasma and Red Blood Cells. American Journal of Clinical Nutrition, 8, 846-854.
Suhaila, R., Nasir, K., Shujaat, A., Nasim, U. and Mohammad, Z.I. (2004) Essential Trace Metals in Human Whole Blood in Relation to Environment. Pakistan Journal of Medical Research, 43, 1-5.
Mary, R.L.A., Kelvin, A.C., Sheila, D. and William, H.R. (2000) Nutrient Risk Assessment Implication for Food Fortification Policy, In: Rousel, A.M., Anderson, R.A. and Favrier, A., Eds., Trace Elements in Man and Animals, Kluwer Academic Publications, New York, Boston, Dordrecht, Lands, Moscow, 215-220.
Prasad, A.S., and Oberleas, D. (1970) Binding of Zinc to Amino Acids and Serum Proteins in Vitro. Journal of Laboratory and Clinical Medicine, 76, 416-425.
Riordan, J.F. and Vallee, B.L. (1976) Structure and Function of Zinc Metalloenzymes. In: Prasad, A.S., Ed., Trace Elements in Human Health and Disease, Vol. 1, Academic Press, New York, 227-251.
Chavapil, M., Zukowski, C.F., Hattler, B.G., Stankova, L., Montgomery, D., Carlson, E.C. and Ludwig, J.C. (1976) Zinc and Activity of Cell Membrane. In: Prasad, A.S., Ed., Trace-Elements in Human Health and Disease, Vol. 1, Academic Press, New York, 269-281.
Prasad, A.S., Schulert, A.R., Sandstead, H.H., Miale Jr., A. and Farid, Z. (1963) Zinc, Iron and Nitrogen Content of Sweat in Normal and Deficient Subjects. Journal of Laboratory and Clinical Medicine, 62, 84-89.
Henkin, R.I., Patten, B.M., Re, P.K. and Bronzett, D.A. (1975) A Syndrome of Acute Zinc Loss. Archives of Neurology, 32, 745-751. http://dx.doi.org/10.1001/archneur.1975.00490530067006
Dresti, I.E. (1984) Zinc in the Central Nervous System: The Emerging Interactions. In: Frederickson, C.J., Howell, G.A. and Kasarskis, E.J., Eds., The Neurobiology of Zinc Part A, Alan R.L., New York, 1-26.
Gramick, S. (1946) Ferritin IX. Increase of the Protein Apoferritin in the Gastrointestinal Mucosa as a Direct Response to Iron Feeding. The Function of Ferritin in the Regulation of Iron Absorption. The Journal of Biological Chemistry, 164, 737-746.
Moore, C.V., Doan, C.A. and Arrowsmith, W.R. (1937) Studies in Iron Transportation and Metabolism, Mechanism of Iron Transportations: Its Significance in Iron Utilization in Anemic States of Varied Etiology. Journal of Clinical Investigation, 16, 627-648. http://dx.doi.org/10.1172/JCI100889
Mahler, H.R. and Elowe, D.G. (1953) DPNH-Cytochrome Reductase, a Ferroflavo Protein. Journal of the American Chemical Society, 75, 5769-5770. http://dx.doi.org/10.1021/ja01118a536
Ingram, D.J.E., Gibson, J.F. and Perutz, M.F. (1956) Orientation of the Four Heme Groups in Hemoglobin. Nature, 178, 906-908. http://dx.doi.org/10.1038/178906a0
Holmberg, G.C. and Laurell, C.B. (1947) Investigations in Serum Copper I. Nature of Serum Copper and Its Relation to the Iron-Binding Protein in Human Serum. Acta Chemica Scandinavica, 1, 944-950. http://dx.doi.org/10.3891/acta.chem.scand.01-0944
Schade, A.L., Reinhart, R.W. and Levy, H. (1949) Carbon Dioxide and Oxygen in Complex Formation with Iron and Siderophilin, the Iron-Binding Compound of Human Plasma. Archives of Biochemistry and Biophysics, 20, 170-172.
Lipschitz, D.A., Cook, J.D. and Finch, C.A. (1974) A Clinical Evaluation of Serum Ferritin as an Index of Iron Stores. The New England Journal of Medicine, 290, 1213-1216. http://dx.doi.org/10.1056/NEJM197405302902201
Simes, M.A., Addiego Jr., J.E. and Dallman, P.R. (1974) Ferritin in Serum: Diagnosis of Iron Deficiency and Iron Overload in Infants and Children. Blood, 43, 581-590.
Aikawa, J.K. (1976) Biochemistry and Physiology of Magnesium. In: Prasad, A.S., Ed., II. Trace Elements in Humans: Health and Diseases, Academic Press, New York, 47-78.
Classen, H.G. (1984) Magnesium and Potassium Deprivation and Supplementation in Animals and Man: Aspects in View of Intestinal Absorption. Magnesium, 3, 257-264.
Krasner, B. (1979) Cardiac Effects of Magnesium with Special Referenceto Anaesthesia: A Review. Canadian Anaesthetists’ Society Journal, 26, 181-185. http://dx.doi.org/10.1007/BF03006978
Furukawa, Y. and Chiba, S. (1981) Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart. Japanese Heart Journal, 22, 239-246.
Stark, G., Stark, U., Pilger, E., Honigl, K., Bertuch, H. and Tritthart, H.A. (1989) The Influence of Elevated Mg2 Concentrations on Cardiac Electrophysiological Parameters. Cardiovascular Drugs and Therapy, 3, 183-189. http://dx.doi.org/10.1007/BF01883863
Haigney, M.C.P., Berger, R., Schulman, S., Gerstenblith, G., Tunin, C., Silver, B., Silverman, H.S., Tomaselli, G. and Calkins, H. (1997) Tissue Magnesium Levels and the Arrhythmic Substrate in Humans. Journal of Cardiovascular Electrophysiology, 8, 980-986. http://dx.doi.org/10.1111/j.1540-8167.1997.tb00620.x
Ireland, P. and Fordtran, J.S. (1973) Effect of Dietary Calcium and Age on Jejunal Calcium Absorption in Humans Studied by Intestinal Perfusion. Journal of Clinical Investigation, 52, 2672-2681. http://dx.doi.org/10.1172/JCI107461
Heaney, R.P., Saville, P.D. and Recker, R.R. (1975) Calcium Absorption as a Function of Calcium Intake. The Journal of Laboratory and Clinical Medicine, 85, 881-890.
Morris, H.A., Need, A.G., Horowitz, M., O’Loughlin, P.D. and Nordin, B.E. (1991) Calcium Absorption in Normal and Osteoporotic Postmenopausal Women. Calcified Tissue International, 49, 240-243. http://dx.doi.org/10.1007/BF02556211
Ebeling, P.R., Yergey, A.L., Vieira, N.E., Burritt, M.F., O’Fallon, W.M., Kumar, R. and Riggs, B.L. (1994) Influence of Age on Effects of Endogeneous 1,25-Dihydroxyvitamin D on Calcium Absorption in Normal Women. Calcified Tissue International, 55, 330-334. http://dx.doi.org/10.1007/BF00299309
Need, A.G., Morris, H.A., Horowitz, M., Scopacasa, E. and Nordin, B.E. (1998) Intestinal Calcium Absorption in Men with Spinal Osteoporosis. Clinical Endocrinology, 48, 163-168. http://dx.doi.org/10.1046/j.1365-2265.1998.3681181.x
Kent, G.N., Price, R.I., Gutteridge, D.H., Allen, J.R., Barnes, M.P., Hickling, C.J., Retallack, R.W., Wilson, S.G., Devlin, R.D., Price, R.I., Smith, M., Bhagat, C.I., Davies, C. and St. Johns, A. (1990) Human Lactation: Forearm Trabecular Bone Loss, Increased Bone Turnover, and Renal Conservation of Calcium and Inorganic Phosphate with Recovery of Bone Mass Following Weaning. Journal of Bone and Mineral Research, 5, 361-369. http://dx.doi.org/10.1002/jbmr.5650050409
Lopez, J.M., Gonzalez, G., Reyes, V., Campino, C. and Diaz, S. (1996) Bone Turnover and Density in Healthy Women during Breastfeeding and after Weaning. Osteoporosis International, 6, 153-159. http://dx.doi.org/10.1007/BF01623940
Chan, G.M., McMurray, M., Westover, K., Engelbert-Fenton, K. and Thomas, M.R. (1987) Effects of Increased Dietary Calcium Intake upon the Calcium and Bone Mineral Status of Lacting Adolescent and Adult Women. The American Journal of Clinical Nutrition, 46, 319-323.
Bongiorni-Malave, I.B. and Pocino, M. (1980) Abnormal Regulatory Control of the Antibody Response to Hetrologous Erythrocytes in Protein-Calorie-Malnourished Mice. Clinical Immunology and Immunopathology, 16, 19-29. http://dx.doi.org/10.1016/0090-1229(80)90162-2
Gershwin, M.E., Keen, C.L., Fletcher, M.P. and Hurley, L.S. (1988) Trace Element Deficiencies and Immune Responsiveness. In: Hurley, L.S., Keen, C.L., Lonnerdal, B. and Rucker, R.B, Eds., Trace Elements in Man and Animals, Plenum Press, New York and London, 85-89.
Rigas, D.A., Rigas, E.C. and Head, C. (1979) Biophasic Toxicity of Diethyldithiocarbamate, a Metal Chelator, to T Leymphocytes and Polymorphonucuclear Granulocytes: Reversal by Zinc and Copper. Biochemical and Biophysical Research Communications, 88, 373-379. http://dx.doi.org/10.1016/0006-291X(79)92058-8
Daniel, P.P. (1988) Aluminum and Alzheimer’s Disease; Methodologic Approaches. In: Sigel, H. and Sigel, A., Eds., Metal Ions in Biological Systems, Vol. 24, Marcel Dekker, Inc., New York, 259-283.
Ehmann, W.D., Markesbery, W.R., Alauddin, M., Hassain, T.I. and Brubaker, E.H. (1986) Brain Trace Elements in Alzheimer’s Disease. Neurotoxicology, 7, 197-206.
Cornett, C.R., Markesbery, W.R. and Ehmann, W.D. (1998) Imbalances of Trace Elements Related to Oxidative Damage in Alzheimer’s Disease Brain. Neurotoxicology, 19, 339-345.
Huseyin, V., Hilmi, D., Yusuf, K., Ibrahim, E. and Namik, D. (2010) Alterations of Plasma Magnesium, Copper, Zinc, Iron, and Selemium Concentrations and Some Related Erythrocyte Antioxidant Enzyme Activities in Patients with Alzheimer’s Disease. Journal of Trace Elements in Medicine and Biology, 24, 169-173. http://dx.doi.org/10.1016/j.jtemb.2010.02.002
Ashley, I.B. and Tanzi, R.E. (1995) The Role of Zinc in the Cerebrad Deposition of Aβ Amyloid in Alzheimer’s Disease. In: Iqbal, K., Mortimen, J.A., Winblad, B. and Wisniewski, H.M., Eds., Research Advances in Alzheimer’s Disease and Related Disorders, John Wiley & Sons, Hoboken, 607-618.
Wenstrup, D., Ehmann, W.D. and Markesbery, W.R. (1990) Trace Element Imbalance in Isolated Sub Cellular Fractions of Alzheimer’s Disease Brains. Brain Research, 533, 125-131. http://dx.doi.org/10.1016/0006-8993(90)91804-P
Hershey, C.O., Hershey, L.A., Varnes, A., Vibhakar, S.D. and Lavin, P. and Strain, W.H. (1983) Cerebrospinal Fluid Trace Element Content in Dementia: Clinical Radiologic and Pathologic Correlations. Neurology, 33, 1350-1353. http://dx.doi.org/10.1212/WNL.33.10.1350
Lui, E., Fisman, M., Wang, C. and Diaz, F. (1990) Metals and the Liver in Alzheimer’s Disease: An Investigation of Hepatic Zinc, Copper, Cadmium and Metallothianein. Journal of the American Geriatrics Society, 38, 633-639.
Backstrom, J.R., Miller, C.A. and Tokde’s, Z.A. (1992) Characterization of Neutral Proteinases from Alzheimer-Affected and Control Brain Specimens: Identification of Calcium-Dependent Metalloproteinase from the Hippocampus. Journal of Neurochemistry, 58, 983-992. http://dx.doi.org/10.1111/j.1471-4159.1992.tb09352.x
Uchida, Y., Takio, K., Titani, K., Ihara, Y. and Tomonaga, M. (1991) The Growth Inhibitory Factor That Is Deficient in the Alzheimer’s Disease Brain Is a 68-Amino Acid Metallothianein-Like Protein. Neuron, 7, 337-347. http://dx.doi.org/10.1016/0896-6273(91)90272-2
Franceschi, C., Chiricolo, M., Licastro, F., Zannotti, M., Masi, M., Macchegiani, E. and Fabris, N. (1988) Oral Zinc Supplementation in Down’s Syndrome: Restoration of Thymic Endocrine Activity and Some Immune Defects. Journal of Mental Deficiency Research, 32, 169-181.
Bjorkstem, B., Back, O., Gustavason, K.H., Hallmans, G., Hagglof, B. and Tarnvik, A. (1980) Zinc and Immune Function in Down’s Syndrome. Acta Paediatrica Scandinavica, 69, 183-187.
Napolitano, G., Palka, G., Grimaldi, S., Giuliani, C., Laglia, G., Calabarese, G., Satta, M.A., Neri, G. and Monaco, F. (1990) Growth and Delay in Down Syndrome and Zinc Sulphate Supplementation. American Journal of Medical Genetics. Supplement, 7, 63-65.
Mc Lachlan, C., Kruck, T.P., Lukiw, W.J. and Krishnan, S.S. (1991) Would Decreased Aluminium Ingestion Reduce the Incidence of Alzheimer’s Disease? Canadian Medical Association Journal, 145, 793-804.
Frederickson, C.J., Klitenick, M.A., Manten, W.I. and Kirkpatrick, J.B. (1983) Cytoarchitectonic Distribution of Zinc in the Hippocampus of Man and the Rat. Brain Research, 272, 335-339. http://dx.doi.org/10.1016/0006-8993(83)90858-2
Frederickson, C.J. (1989) Neurobiology of Zinc and Zinc Containing Neurons. International Review of Neurobiology, 31, 145-328. http://dx.doi.org/10.1016/S0074-7742(08)60279-2
Choi, D.W., Yokoyama, M. and Koh, J. (1988) Zinc Neurotoxicity in Cortical Cell Culture. Neuroscience, 24, 67-79. http://dx.doi.org/10.1016/0306-4522(88)90312-0
Stewart, G.R., Frederickson, C.J., Howell, G.A. and Gage, F.H. (1984) Choleinergicdeneutruation Induced Increase of Chelatable Zinc in Mossy-Fiber Region of the Hippocampal Formation. Brain Research, 290, 43-51. http://dx.doi.org/10.1016/0006-8993(84)90734-0
Hyman, B.T., Van Hoesen, G.W, Kroner, L.J. and Damasio, A.R. (1986) Perforant Pathway Changes and the Memory Impairment of Alzheimer’s Disease. Annals of Neurology, 20, 472-481. http://dx.doi.org/10.1002/ana.410200406
Hicks, N.M., Brammer, M.J., Hymans, N. and Levy, R. (1987) Platelet Membrane Properties in Alzheimer’s and Multi-Infarct Dementias. Alzheimer Disease and Associated Disorders, 1, 90-97. http://dx.doi.org/10.1097/00002093-198701020-00004
Sandstrom, B., Arvidsson, B., Cederblad, A. and Bjorn-Rasmussen, E. (1980) Zinc Absorption from Composite Metals I. The Significance of Wheat Extraction Rate, Zinc, Calcium, and Protein Content in Metals Based on Bread. American Journal of Clinical Nutrition, 33, 739-745.
Markesbery, W.R., Ehmann, W.D., Hossain, T.I.M., Alauddin, M. and Goodin, D.T. (1981) Instrumental Neutron Activation Analysis of Brain Aluminium in Alzheimer’s Disease and Aging. Annals of Neurology, 10, 511-516. http://dx.doi.org/10.1002/ana.410100604
Ehmann, W.D., Markesbery, W.R. and Alauddin, M. (1984) Quantitation, Localization and Variations of Brain Zinc with Aging by Instrumental Neuton Activation Analysis. In: Frederickson, C.J., Howell, G.A. and Kassarskis, E.J., Eds., Neurobiology of Zinc. Part A. Physiochemistry, Anatomy, and Techniques, Alan R. Liss, New York, 329-342.
Hershey, L.A., Hershey, C.O., Varnes, A.W., Wongmongkolrit, T. and Strain, W.H. (1984) Zinc Content in CSF, Brain and Other Tissues in Alzheimer’s Disease and Aging. In: Frederickson, C.J., Howell, G.A. and Kassarskis, E.J., Eds., The Neurobiology of Zinc. Part B. Deficiency, Toxicity and Pathology, Alan R. Liss, New York, 325-334.
Markesbery, W.R. and Ehmann, W.D. (1994) Brain Trace Elements in Alzheimer’s Disease. In: Terry, R.D., Katzman, R. and Bick, K.L., Eds., Alzheimer’s Disease, Raven Press Ltd., New York, 353-367.
Goodman, L. (1953) Alzheimer’s Disease: A Clinico-Pathologic Analysis of Twenty Three Cases with a Theory on Pathogenesis. The Journal of Nervous and Mental Disease, 117, 97-130. http://dx.doi.org/10.1097/00005053-195308000-00001
Good, P.F., Perl, D.P., Bierer, L.M. and Schmeidler, J. (1992) Selective Accumulation of Aluminum and Iron in the Neurofibrillary Tangles of Alzheimer’s Disease: A Laser Microprobe (LAMMA) Study. Annals of Neurology, 31, 286- 292. http://dx.doi.org/10.1002/ana.410310310
Andorn, M.C., Britten, R.S. and Bacon, B.R. (1990) Evidence That Lipid Peroxidation and Total Iron Are Increased in Alzheimer’s Brain. Neurobiology of Aging, 11, 316-323. http://dx.doi.org/10.1016/0197-4580(90)90814-G
Connor, J.R., Menzies, S.L., St. Martin, S.M., Mufison, E.J. (1992) A Histochemical Study of Iron, Transferrin and Ferritin in Alzheimer’s Diseased Brains. Journal of Neuroscience Research, 31, 75-83. http://dx.doi.org/10.1002/jnr.490310111
Fleming, J. and Joshi, J.G. (1987) Ferritin: Isolation of Aluminum-Ferritin Complex from Brain. Proceedings of the National Academy of Sciences of the United States of America, 84, 7866-7870. http://dx.doi.org/10.1073/pnas.84.22.7866
Switzer, R.C., Martin, T.L., Campbell, S.K., Parker, J.C. and Caldwell, E.D. (1986) Iron and Ferritin in the Neuritic Plaques of Alzheimer’s Disease. Society for Neuroscience Abstracts, 100.
Grundke-Iqbal, I., Fleming, J., Tung, Y.C., Lassmann, H., Iqbal, K. and Joshi, J.G. (1990) Ferritin Is a Component of the Neuritic (Seniles) Plaque in Alzheimer Dementia. Acta Neuropathologica, 81, 105-110. http://dx.doi.org/10.1007/BF00334497
Connor, J.R. Menzies, S.L., St. Martin, S.M. and Mufsan, E.J. (1990) Cellular Distribution of Transferrin, Ferritin, and Iron in Normal and Aged Human Brains. Journal of the Neurological Sciences, 27, 595-611.
Peterson, C., Gibson, G.E. and Blass, J.P. (1985) Altered Calcium Uptake in Cultured Skin Fibroblasts from Patients of Alzheimer’s Disease. The New England Journal of Medicine, 312, 1063-1064. http://dx.doi.org/10.1056/NEJM198504183121618
Ito, E., Oka, K., Etcheberrigaray, R., Nelson, T.T., Mcphie, D.L., Totel-Grehl, B., Gibson, G.E. and Alkan, D.L. (1994) Internal Ca2 Mobilization Is Altered in Fibroblasts from Patients with Alzheimer’s Disease. Proceedings of the National Academy of Sciences of the United States of America, 91, 534-538. http://dx.doi.org/10.1073/pnas.91.2.534
Peterson, C., Ratan, R. R., Shelanski, M. L. and Goldman, J. E. (1986) Cytosolic Free Calcium and Cell Spreading Decrease in Fibroblasts from Aged and Alzheimer’s Donors. Proceedings of the National Academy of Sciences of the United States of America, 83, 7999-8001. http://dx.doi.org/10.1073/pnas.83.20.7999
Peterson, C. and Goldman, T.E. (1988) Alteration in Calcium Content and Biochemical Processes in Cultured Skin Fibroblasts from Aged and Alzheimer’s Donors. Proceedings of the National Academy of Sciences of the United States of America, 83, 2758-2762. http://dx.doi.org/10.1073/pnas.83.8.2758
Chakroborty, S. and Slutzmann, G.E. (2011) Early Calcium Dysregulation in Alzheimer’s Disease: Setting the Stage for Synaptic Dysfunction. Science China. Life Science, 54, 752-762.
Huang, H.M., Toral-Barza, L., Thaler, H., Totel-Grehl, B. and Gibson, G.E. (1991) Inositol Phosphates and Interacellular Calcium after Bradykinin Simulation in Fibroblasts from Young, Normal Aged and Alzheimer’s Donors. Neurobiology of Aging, 12, 469-473. http://dx.doi.org/10.1016/0197-4580(91)90075-U
Borden, L.A., Maxfield, F.R., Goldman, J.E. and Shelanski, M.L. (1992) Resting [Ca2 ]i and [Ca2 ]i Transient Are Similar in Fibrablasts from Normal and Alzheimer’s Disease Donors. Neurobiology of Aging, 13, 33-38. http://dx.doi.org/10.1016/0197-4580(92)90005-I
Khachaturian, Z.S. (1984) Towards Theory of Brain Aging. In: Kay, D.S. and Burrows, G.W., Eds., Handbook of Studies on Psychiatry and Old Age, Elsevier, Amsterdam, 7-30.
Canzoniero, L.M. and Snider, B.J. (2005) Calcium in Alzheimer’s Disease Pathogenesis: Too Much, Too Little or in the Wrong Place. Journal of Alzheimer’s Disease, 8, 147-154.
Woods, N.K. and Padmanabhan, J. (2012) Neuronal Calcium Signalling and Alzheimer’s Disease. Advances in Experimental Medicine and Biology, 740, 1193-1217. http://dx.doi.org/10.1007/978-94-007-2888-2_54
Pascale, A. and Etcheberrigaray, R. (1997) Calcium Alterations in Alzheimer’s Disease: Pathophysiology, Models and Therapeutic Opportunities. Pharmacological Research, 39, 81-88. http://dx.doi.org/10.1006/phrs.1998.0411
Bojarski, L., Herms, J. and Kuznicki, J. (2008) Calcium Dyes Regulation in Alzheimer’s Disease. Neurochemistry International, 52, 621-633. http://dx.doi.org/10.1016/j.neuint.2007.10.002
Cilliler, A.E., Ozturk, S. and Ozbakir, S. (2007) Serum Magnesium Level And clinical Deterioration in Alzheimer’s Disease. Gerontology, 53, 419-422. http://dx.doi.org/10.1159/000110873
Ali, S.S., Mahdi, F., Jatar, M., Mohammad, M. and Robas, M. (2013) Study on Serum Magnesium Level in Alzheimer’s Disease and Its Relationship with the Stage of Disease. Medical Journal of Tabriz University of Medical Science, 32, 57-621.
Glick, J.L. (1990) Dementias: The Role of Magnesium Deficiency and an Hypothesis Concerning the Pathogenesis of Alzheimer’s Disease. Medical Hypotheses, 31, 211-225. http://dx.doi.org/10.1016/0306-9877(90)90095-V
Korf, J., Gramsbergn, J.B.P., Prenen, G.H.M. and Go, K.G. (1986) Cation Shifts and Excitotoxins in Alzheimer and Huntington Disease and Experimental Brain Damage. Progress in Brain Research, 70, 213-226. http://dx.doi.org/10.1016/S0079-6123(08)64306-X
Barbagallo, M., Beluedere, M., Di Bella, G. and Domingues, L.J. (2011) Dementia Less Likely with Increased Levels of Magnesium etc. Magnesium Research, 24, S115-S121.
Mielke, M.M., Zandi, P.P., Blennow, K., Gustafson, D., Sjogren, M. Rosengren, L. and Skoog, I. (2006) Low Serum Potassium in Mid Life Associated with Decreased Cerebrospinal Fluid Aβ42 in Late Life. Alzheimer Disease and Associated Disorders, 20, 30-36. http://dx.doi.org/10.1097/01.wad.0000201848.67954.7d
Diebel, M.A., Ehmann, W.D. and Markesbery, W.R. (1996) Copper, Iron and Zinc Imbalances in Severely Degenerated Brain Regions in Alzheimer’s Disease: Possible Relation to Oxidative Stress. Journal of the Neurological Sciences, 143, 137-142. http://dx.doi.org/10.1016/S0022-510X(96)00203-1
Huseyin, V., Hilmi, D., Yusuf, K., Ibrahim, E. and Nam, K.D. (2010) Alterations of Plasma Magnesium, Copper, Zinc, Iron and Selenium Concentrations and Some Related Erythrocyte Antioxidant Enzyme Activities in Patients with Alzheimer’s Disease. Journal of Trace Elements in Medicine and Biology, 24, 169-173. http://dx.doi.org/10.1016/j.jtemb.2010.02.002
Philip, G.S. (1992) Theory of the Aetiology of Alzheimer’s Disease. Brain Biochemistry and Brain Disorders, Oxford University Press, Oxford, New York, 342.
Mattiello, G., Gerotto, M., Favarato, M., Lazzari, F., Gasparoni, G., Goniratu, L., Mazzolini, G., Scarpa, G., Zanoboni, V., Pilone, M.G. and Zafta, P.F. (1993) Plasma Micro Elemental Analysis from Alzheimer’s and Multi Infarctual Dementia Patients. In: Corain, B., Iqbal, K., Nicolini, M., Winblad, B., Wisneiwski, H. and Zatta, P., Eds., Alzheimer’s Disease: Advances in Clinical and Basic Research, John Wiley & Sons, Hoboken, 267-272.
Cornett, C.R., Ehmann, W.D. and Wekstein, D.R. and Markesbery, W.R. (1998) Trace Elements in Alzheimer’s Disease Pituatry Glands. Biological Trace Element Research, 62, 107-114. http://dx.doi.org/10.1007/BF02820026
Walsh, A. (1956) The Application of Atomic Absorption Spectra to Chemical Analysis. Spectrochimica Acta, 7, 108- 117. http://dx.doi.org/10.1016/0371-1951(55)80013-6
John, H., Maxwell, J.D., Stewart, D.A., Parsons, V. and Williams, R. (1971) Altered Calcium Metabolism in Epileptic Children on Anti-Convulsants. British Medical Journal, 4, 202-204. http://dx.doi.org/10.1136/bmj.4.5781.202
Prasad, R., Singh, A., Das, B.K., Upadhyay, R.S., Singh, T.B. and Mishra, O.P. (2009) Cerebrospinal Fluid and Serum Zinc Copper, Magnesium and Calcium Levels in Children with Idiopathic Seizure. Journal of Clinical and Diagnostic Research, 3, 1841-1846.
Avci, H., Kizilkan, N. and Yaman, M., (2008) Comparison of Trace Elements Concentrations in Scalp Hair of Epileptic and Normal Subjects. Trace Elements and Electrolytes, 25, 147-155. http://dx.doi.org/10.5414/TEP25147
Barlow, P.J., Francois, P.E., Goldberg, I.J. Richardson, I., Izmeth, M.G., Kumpeson, K. and Sykes, P. (1986) Trace Metal Abnormalities in Long Stay Hyperactive Mentally Handicapped Children and Agitates Senile Dements. Journal of the Royal Society of Medicine, 79, 581-583.
Khanna, R.S., Kumar, R., Asthana, R.K., Negi, R., Pande, D., Kumar, A. and Khanna, H.D. (2009) Role of Trace Element and Antioxidants in Free Radical Mediated Injury in Neonates. MASAUM Journal of Basic and Applied Science, 1, 543-547.
Adnan, M., Ahmed, G., Khaled, O., Indress, A.M., Ahmed, A., Hiatham, T. and Wall, H. (2010) Simultaneous Determination of Cd, Pd, Cu Zn and Se in Human Blood of Jordanian Smokers by ICP-OES. Biological Trace Element Research, 133, 1-11. http://dx.doi.org/10.1007/s12011-009-8405-y
Guidotti, T.L., McNamra, J. and Moses, M.S. (2008) The Interpretation of Trace Element Analysis in Body Fluids. Indian Journal of Medical Research, 128, 524-532.
Deniz, T., Ali, H.T. and Saraymen, R (2008) The Effects of Antiepileptic Drugs on Serum and Hair Trace Element Levels. Ankara üniversitesi Tip Fakültesi Mecmuasi, 61, 73-76.
Soylak, M., Saracoglu, S., Divrikli, U. and Elci, L. (2001) Copper and Zinc Concentrations of Serum Samples of Healthy People Living in Tokat, Turkey. Trace Element and Electrolytes, 18, 47-40.
Delves, H.T., Clayton, B.E. and Bicknel, J. (1973) Concentration of Trace Metals in the Blood of Children. British Journal of Preventive Social Medicine, 27, 100-107.
Kumar, S., Bajaj, M., Jain, D.C. and Yadav, H.S. (1988) A Search for the Trace Elemental Deficiencies in Grand Mal Epilepsy Using Atomic Absorption Spectrophotometric Technique and Catalytic Agent in the Cellular Enzyme Reaction. Proceedings of the World Congress on Clinical Nutrition, 1, 115A-121A.
Smith, W.G. and Bone, I. (1982) Copper, Zinc and Magnesium Plasma Levels in Epilepsy. Journal of Neurology, Neurosurgery Psychiatry, 45, 1072-1073. http://dx.doi.org/10.1136/jnnp.45.11.1072
Kaji, M., Ito, N., Okuno, T., Momoi, T., Sasaki, H., Yamanake, C., Yorifuji, T. and Mikawa, H. (1992) Serum Copper and Zinc Levels in Epileptic Children with Valporate Treatment. Epilepsia, 33, 555-557. http://dx.doi.org/10.1111/j.1528-1157.1992.tb01709.x