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Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.

Feb 09, 2017Open    AccessArticle

Methods for Non-Destructively Separating or Reannealing the Strands of Circular Duplex DNA Chromosomes

Ken Biegeleisen
Although it is not widely-known, the strands of circular duplex plasmid and viral chromosomes have been non-destructively separated, and the separated strands have been reconstituted to yield a new duplex structure with all the properties of the native chromosome restored. This suggests a paranemic structure for the DNA, that is, a structure whose strands are no

Jul 26, 2016Open    AccessArticle

Targeted Mutagenesis of Beta-Lactoglobulin Gene in Caprine Fetal Fibroblasts by Context-Dependent Assembly Zinc-Finger Nucleases

Yuguo Yuan, Yong Cheng, Jinyu Wang, Qiuling Peng
Targeted mutagenesis by zinc-finger nucleases (ZFNs) can be used to generate knock-out mammalian cell lines with high efficiency. A number of different methods have been developed for the design and assembly of gene-specific ZFNs, making them easily accessible to researchers. In this study, we used ZFNs assembled through the CoDA (context-dependent assembly) platforms to generate mutant caprine fetal fibroblasts cells for the BLG

Sep 10, 2014Open    AccessArticle

Opportunities, Constraints and Future Implication of Biotechnology in Animlal Feed Improvement

Bimrew Asmare
The major cause of poor livestock productivity in tropical regions of the world is inadequate nutrition. The shortage of feed in most developing countries and the increasing cost of feed constituents entail that there is a call for to improvement feed utilization strategies in developing countries. Animal feeds and feeding practices can be enhanced by biotechnology to develop better animal nutrition packages in smallholder and commercial production systems as well as to reduce environmental wast...