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Jun 28, 2023Open Access
We performed aurora kinase gene expression analysis, in combination with FISH and micronucleus test, in buccal mucosa cells isolated from agricultural workers to better understand the dynamics of genomic instability in these groups of professionals. Two out of a total of 97 agricultural workers who consented to participate in the study (39 men and 58 women) reported a history of cancer based on a previously applied questionnaire. The participants were 28.4 years on average and were categorized i...
Jun 13, 2023Open Access
The article theoretically and experimentally substantiates a new method in the free-radical theory of aging, where the target is not the free radicals but the DNA molecules; while radioprotectors are used as antioxidants, previously used to protect the body from radiation damage. A brief overview of various strategies and methods in gerontology is provided. In the quasicrystalline model of DNA, the role of impurity levels is considered. The electronic spectra of DNA bases were calculated by the ...
Mar 29, 2023Open Access
The effect of centimeter waves of non-thermal level on four types of bacteria has been studied. On E. coli strains, a sharp increase in survival during the first cycle of cell division was obtained. The mechanism of inhibition of pathogenic bacteria by a weak electromagnetic field is explained. The mechanism of stimulating the survival of bacteria associated with the activation of genes that reduces the number of dying bacteria is explained. The general form of the modified Ferhulst equat...
Dec 23, 2022Open Access
Autophagy is an important biological mechanism to transport proteins in organelles to lysosome for degradation, maintaining a stable physiological balance of the body. Acute Myeloid Leukemia (AML) refers to hematological malignancy caused by a disorder of myeloid hematopoietic stem cells. Recent studies have shown that the expression of some autophagy-related genes in AML patients is closely related to the prognosis and leukocyte formation of AML patients. Therefore, we can use autophagy as a po...
Aug 25, 2021Open Access
Telomere is a structure of the repetitive DNA sequence TTAGGG and protein complex, found in vertebrates. This protein complex is known as the shelterin complex. It is localized at the end of each chromosome to protect them from deterioration or fusion with other chromosomes. Although as being part of a chromosome, the telomere is inherited from parents to their offspring, its mode of inheritance is a crucial part of the genetic transmission process. Theoretically, germ cells are thought to be im...
May 07, 2021Open Access
The hallmarks of cancer are determined by cancer-associated gene expression pattern that is determined by cancer-associated chromatin configuration (CACC). Using non-carcinogenic genotoxic drugs (NCGDs) to alter CACC could change cancer-associated gene expression pattern, which in turn, might cause disappearance of some or whole hallmarks of cancer and as a result, cancer cells could be killed by either apoptosis or immune destruction. Therefore, cancer could be prevented and treated by administ...
Feb 26, 2021Open Access
As a kind of important innate lymphocytes in vivo, Natural killer (NK) cells have a rapid and efficient capacity to recognize and destroy tumor cells, senescent cells and virus-infected cells. In the past decades, NK cells have been widely applied in the treatment of hematological malignancies in clinic, even solid tumors. Successful results have been made against hematological malignancies (NCT00697671, NCT00990717, NCT00145626), but also a number of considerable challenges have been encountere...
Jul 08, 2020Open Access
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
May 15, 2020Open Access
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Mar 11, 2020Open Access
Sickle cell anemia is a blood disorder linked to an abnormality in the structure of hemoglobin. The objective of this study was to determine the frequency of the sickle cell gene on the basis of early detection of hemoglobin using the isoelectric focusing technique in maternities in Lubumbashi. Our descriptive cross-sectional study consisted of newborns and infants up to 6 months of age. The capillary venous blood was collected on the finger for the rapid and direct test and on blotting paper fo...
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