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Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.
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Mar 26, 2018Open    AccessArticle

The Peripheral Hypotheses of Hypothalamic Aging

Zi-Jian Cai
It is well known that the hypothalamic changes in control of hormones determine the chronological sequence of aging in mammals. For decades, it has been demonstrated in humans that the hypothalamic nuclei manifest heterogeneity in degeneration during aging, with the neuron number decreasing in both the suprachiasmatic nucleus (SCN) and the preoptic sexually dimorphic nucleus (SDN-POA) in the process of senescence, while the neuron
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Dec 08, 2016Open    AccessArticle

The Advantage of Asymmetrical Handedness in Cooperation with Heartbeat: A Hypothesis from the Chinese Member of Satellite Group

Zi-Jian Cai
Recently, it was published the book “Electromagnetic Unification of Four Forces” (ISBN 978-3-659-76798-2), compiling the progressions in physics manifested in television, made by the world people while led notably by the author and the members in the world satellite networks from India, Zhejiang and USA. Besides these significant achievements, it has also been made many activities and achievements on neural sciences. In this artic
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Feb 03, 2016Open    AccessArticle

Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

Zi-Jian Cai
In this article, it is newly suggested the regulation from nutrient gradient on both cell metabolic state and expressional gene classes as the conserved mechanism differentiating the cell fates for formation of the three germ layers of gastrula in animals. As a new theory, it is supported by the totipotency and pluripotency of early embryonic cells and cultured stem cells to be regulated by nutrients, as well as by the universal formation of nutrient gradient during gastrulation in various anima...


Jun 25, 2015Open    AccessArticle

Termination of Organogenesis as Intrinsic Constraint on Animal Development and Evolution: A Theory

Zi-Jian Cai
In this article, it is pointed out with integrative analysis that organogenesis manifests limitation in time and possession of termination, while infinite cell proliferation called as cancer and tumor is lethal. Besides, it is reversely demonstrated from a few notable constant outgrowing skin derivatives that termination is required for organogenesis inside the animal. Accordingly, it is suggested that the requirement for organogenetic termination would be the new intrinsic constraint for animal...


Jun 10, 2014Open    AccessArticle

Asymptomatic Anomalous Collateral Artery Derived from the Left Internal Thoracic Artery: Established Strong Collateral Circulation

Patrick J. Buchanan,Olga Malakhova
An anomalous collateral artery was found during the dissection for the pectoralis major myocutaneous flap procedure. This anomalous collateral artery was stemming from the left internal thoracic artery. It is believed that this collateral was formed secondary to congenital aortic coarctation causing abnormal growth of the left fourth aortic arch. This is the first reported case of such a collateral artery in recent literature.


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