Mar 05, 2018Open AccessArticle
The bioactive compounds in
methanol extract of Xylopia aethiopica fruits were determined using a combination of gas chromatography and mass
spectrometry (GC-MS). The compound identification was based on the molecular
structure, molecular mass and calculated fragments. Interpretation on mass
spectrum of GC-MS analyzer (Hewlett Packard GC-MS system) was done using
Feb 28, 2018Open AccessArticle
Over several decades, poly
(lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and
Nano-carriers of therapeutic agents for drug delivery applications. However,
encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs)
necessitates a defined step to understand the effects and interactions of
parameters involved in production process. In pharmaceutics formulations, compared
Jul 26, 2016Open AccessArticle
The present study focused on synthesizing a series of novel derivatives
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been
Mar 31, 2016Open AccessArticle
In the recent work, a series of novel pyran and pyridine and thiophene
derivatives were designed and synthesized starting from 2-benzylidenecyclopentanone. The reactivity of these derivatives
towards different chemical reagent was studied. The antitumor evaluations of
the newly synthesized products were measured and the results showed that some
of the synthesized products showed high cytotoxicity.
Sep 22, 2015Open AccessArticle
The tunable nature of the solubility of various compounds, including
molecules of pharmaceutical and biological interest, in supercritical fluids
(SCFs) makes SCF extraction technology attractive for many separation and purification
processes. Among the different influencing parameters, the most important one
in the supercritical based processes is the knowledge of solubility of model
solute. But, experimental measurement of the solubility of all pharmaceuticals
in wide ranges of temperature and...
Nov 26, 2014Open AccessArticle
Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or
ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f.
The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives
was studied. The anti-tumor evaluation of the newly synthesized compounds
against the three human tumor cells lines namely breast adenocarcinoma (MCF-7),
non-small cell lung cancer (NCI-H460) a...
Sep 10, 2014Open AccessArticle
Metronidazole is a derivative of benzimidazole. It
is being used widely for the treatment of amoebiasis. An efficient, simple and
least time consuming spectrophotometric method for the assay of metronidazole
has been developed. Comparison of assay of three different brands of metroni-da- zole has also been available in public medical stores of Karachi, Pakistan. The assay is based on
the ultraviolet UV absorbance maxima at about 340 nm wavelength of
metronidazole using water as solvent. A sample...
Aug 19, 2014Open AccessArticle
objective of this study is to develop the degradation studies of different
brands of glimepiride available in market. Forced degradation is a powerful
tool used routinely in pharmaceutical development in order to develop stability-indicating
methods that lead to quality stability data and to understand the degradation pathways of the drug substances and drugs.
Glimepiride is a medium- to long-acting sulfonylurea antidiabetic drug
as it is the most prescribed oral antih
Jun 23, 2014Open AccessArticle
An exhaustive literature survey on the secondary
metabolites of widely distributed Prunella vulgaris L. species has been carried out.
Triterpenoids, sterols, phenylpropanoids, flavonoids, coumarins, fatty acids, volatile
oils and carbohydrates along with some other compounds, have been reported from
this species. Many of these compounds have been found to possess significant biological
properties, including antihypertensive activity, antica
Jun 12, 2014Open AccessArticle
Vitex negundo Linn. is a woody plant found mainly in Indian subcontinent and its neighbouring countries. Almost all the sections of the plant possess a massive amount of phytochemical secondary metabolites that impart an unparalleled variety of medicinal uses of the plant. Point to note that a single plant species finds use for treatment of a large spectrum of human health ailments in traditional as well as folk medicines, lion part of which have been experimentally proved to be ab...