OALib Journal
  OALib Journal is an all-in-one open access journal (ISSN Print: 2333-9705, ISSN Online: 2333-9721). It accepts a manuscript for the peer-review processing, typesetting, publication and then allocated to one of the 322 subject areas. The article processing charge for publishing in OALib journal is Only $99. For more details, please contact service@oalib.com. Submit now
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Mar 05, 2018Open    AccessArticle

Bioactive Constituents of Methanol Extract of Xylopia aethiopica (UDA) Fruits from Nsukka, Enugu State, Nigeria

Innocent Uzochukwu Okagu, Uchenna Ekpereamaka Ngwu, Chinyere Jane Odenigbo
The bioactive compounds in methanol extract of Xylopia aethiopica fruits were determined using a combination of gas chromatography and mass spectrometry (GC-MS). The compound identification was based on the molecular structure, molecular mass and calculated fragments. Interpretation on mass spectrum of GC-MS analyzer (Hewlett Packard GC-MS system) was done using

Feb 28, 2018Open    AccessArticle

Ciprofloxacin Hydrochloride Encapsulated into PLGA Nanoparticles for Drug Delivery Application: Fractional Factorial Design

Tajudeen Adebileje, Sikiru Adebileje, P. O. Aye
Over several decades, poly (lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and Nano-carriers of therapeutic agents for drug delivery applications. However, encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs) necessitates a defined step to understand the effects and interactions of parameters involved in production process. In pharmaceutics formulations, compared to

Jul 26, 2016Open    AccessArticle

Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety

Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash
The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been

Mar 31, 2016Open    AccessArticle

The Uses of Cyclopentanone for the Synthesis of Biologically Active Pyran, Pyridine and Thiophene Derivatives

Eman M. Samir
In the recent work, a series of novel pyran and pyridine and thiophene derivatives were designed and synthesized starting from 2-benzylidenecyclopentanone. The reactivity of these derivatives towards different chemical reagent was studied. The antitumor evaluations of the newly synthesized products were measured and the results showed that some of the synthesized products showed high cytotoxicity.

Sep 22, 2015Open    AccessArticle

Comparison between Modeling of Cetirizine Solubility Using Different Approaches: Semi-Empirical Density Based Correlations vs. Peng-Robinson EoS

Mostafa Lashkarbolooki, Ali Zeinolabedini Hezave
The tunable nature of the solubility of various compounds, including molecules of pharmaceutical and biological interest, in supercritical fluids (SCFs) makes SCF extraction technology attractive for many separation and purification processes. Among the different influencing parameters, the most important one in the supercritical based processes is the knowledge of solubility of model solute. But, experimental measurement of the solubility of all pharmaceuticals in wide ranges of temperature and...

Nov 26, 2014Open    AccessArticle

New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity

Rafat M. Mohareb, Sherif M. Sherif, Wagnat W. Wardakhan, Amr S. Abouzied
Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) a...

Sep 10, 2014Open    AccessArticle

Simple UV Spectrophotometric Assay of Metronidazole

Safila Naveed, Fatima Qamar
Metronidazole is a derivative of benzimidazole. It is being used widely for the treatment of amoebiasis. An efficient, simple and least time consuming spectrophotometric method for the assay of metronidazole has been developed. Comparison of assay of three different brands of metroni-da- zole has also been available in public medical stores of Karachi, Pakistan. The assay is based on the ultraviolet UV absorbance maxima at about 340 nm wavelength of metronidazole using water as solvent. A sample...

Aug 19, 2014Open    AccessArticle

Effect of Acid, Base and Time on Different Brands of Glimepiride

Safila Naveed, Hina Qamar, Wardha Jawaid, Urooj Bokhari

The objective of this study is to develop the degradation studies of different brands of glimepiride available in market. Forced degradation is a powerful tool used routinely in pharmaceutical development in order to develop stability-indicating methods that lead to quality stability data and to understand the degradation pathways of the drug substances and drugs. Glimepiride is a medium- to long-acting sulfonylurea antidiabetic drug as it is the most prescribed oral antih


Jun 23, 2014Open    AccessArticle

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

Ge Meng,Mei Wang,Kejie Zhang,Zengjun Guo,Juan Shi

An exhaustive literature survey on the secondary metabolites of widely distributed Prunella vulgaris L. species has been carried out. Triterpenoids, sterols, phenylpropanoids, flavonoids, coumarins, fatty acids, volatile oils and carbohydrates along with some other compounds, have been reported from this species. Many of these compounds have been found to possess significant biological properties, including antihypertensive activity, antica


Jun 12, 2014Open    AccessArticle

Review on Medicinal Usefulness of Vitex negundo Linn

Suparna Rana,Kalyan Kumar Rana
Vitex negundo Linn. is a woody plant found mainly in Indian subcontinent and its neighbouring countries. Almost all the sections of the plant possess a massive amount of phytochemical secondary metabolites that impart an unparalleled variety of medicinal uses of the plant. Point to note that a single plant species finds use for treatment of a large spectrum of human health ailments in traditional as well as folk medicines, lion part of which have been experimentally proved to be ab...