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匹配条件： “妊娠期高血压疾病；临床分级管理；母婴结局；子痫前期；基层医院” ，找到相关结果约1000条。
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妊娠期高血压疾病的临床分级管理
李媛媛，湖北省襄阳市谷城县人民医院妇产科，湖北襄阳，441700
中外临床医学 , DOI: 10.12479/questpress-zwlcyx.20250215
Abstract: 妊娠期高血压疾病（hypertensive disorders of pregnancy, HDP）是妊娠中晚期常见的严重并发症，以高血压、蛋白尿及多器官功能损害为主要特征，是导致孕产妇和围产儿死亡的重要原因之一。目的 深入探讨妊娠期高血压疾病（HDP）临床分级管理模式在基层医疗机构的适用性及母婴结局改善效果。方法 采用回顾性队列研究设计，分析纳入2023年1月—2024年6月某基层医院收治的200例HDP 患者，根据《妊娠期高血压疾病诊治指南》进行精准分级，分为妊娠期高血压（56 例）、轻度子痫前期（78 例）、重度子痫前期（66 例），采用结构化分级管理模式（包括风险分层、动态血压监测、对症解痉降压、适时终止妊娠等），对比三组母婴并发症发生率及管理前后子痫发生率的差异，比较母婴结局。结果 重度子痫前期组剖宫产率（84.8%）、新生儿窒息率（19.7%）显著高于妊娠期高血压组（21.4%、3.6%）和轻度子痫前期组（42.3%、7.7%）（P＜ 0.01）。分级管理后，重度子痫前期患者子痫发生率由历史数据的12.5%降至3.0%。结论 临床分级管理通过资源优化配置和差异化干预，显著降低重度子痫患者及新生儿窒息风险，可优化HDP 患者母婴结局，是基层医院提升妊娠期高血压疾病管理效能的科学路径，适合基层医院推广。
妊娠期高血压疾病对新生儿的危害与临床管理
李占魁,白瑞苗
中国儿童保健杂志 , 2017, DOI: 10.11852/zgetbjzz2017-25-11-12
Abstract: 摘要 妊娠期高血压疾病是妊娠期所特有的疾病,其严重并发症是导致产妇和新生儿病死率升高的主要原因。本文就妊娠期高血压疾病对新生儿结局的影响进行综述,从而系统了解其研究进展,对积极预防和治疗妊娠期高血压疾病、降低围产儿病死率和改善新生儿预后等有重要意义
妊娠期高血压疾病的预防研究进展
Research Progress on Prevention of Hypertensive Disorders of Pregnancy  [PDF]
王英梅, 芦莉
Advances in Clinical Medicine (ACM) , 2023, DOI: 10.12677/ACM.2023.1361360
Abstract: 妊娠期高血压疾病(Hypertensive Disorders of Pregnancy, HDP)是妊娠与血压升高并存的一组疾病，该组疾病包括妊娠期高血压，子痫前期，子痫，以及慢性高血压并发子痫前期和妊娠合并慢性高血压。HDP发生率5.2%~8.2%，是孕产妇和围产儿病死率升高的主要原因。子痫前期是HDP中最常见的，由于现阶段子痫前期的治疗方式有限，且危害较重，子痫前期的预防显得非常重要，并且近年来对预防这种疾病的兴趣以及对其病理生理学的更好理解导致了预防此疾病制剂的研究不断增加，本文综述了该疾病的主要病理生理学机制，并总结目前正在被用于子痫前期的预防或者有预防子痫前期潜力的药物及方法。
Hypertensive Disorders of Pregnancy (HDP) is a group of diseases in which pregnancy and elevated blood pressure coexist. This group of diseases includes gestational hypertension, preeclampsia, ec-lampsia, and chronic hypertension complicated with preeclampsia and pregnancy with chronic hy-pertension. The incidence of HDP is 5.2%~8.2%, which is the main cause of maternal and perinatal mortality. Preeclampsia is the most common type of HDP. Due to the limited treatment of preeclampsia at this stage and the serious harm, the prevention of preeclampsia is very important. In recent years, the interest in preventing this disease and the better understanding of its patho-physiology have led to the prevention of this disease. The research on preparations is increasing. This article reviews the main pathophysiological mechanisms of the disease, and summarizes the drugs and methods that are currently being used for the prevention of preeclampsia or have the potential to prevent preeclampsia.
妊娠期高血压及子痫前期对妊娠及新生儿结局的影响研究
古桂雄,曹志娟,李瑜,王光花,花静
中国儿童保健杂志 , 2016, DOI: 10.11852/zgetbjzz2016-24-05-04
Abstract: 摘要 目的 探讨妊娠期高血压及子痫前期对妊娠及新生儿结局的影响,为育龄妇女孕前、孕期及产后保健提供依据,以减少不良妊娠结局的发生,并为新生儿的健康管理提供预警信息。方法 以前瞻性队列研究为基础的巢式病例对照研究,暴露组84例,其中妊娠期高血压39例、子痫前期45例,按1∶1比例分层随机选择对照组(健康孕妇),使其在分娩年龄、分娩孕周、孕前体质指数、孕次、产次五方面成组匹配,比较两组间妊娠结局及新生儿情况的差别,进一步按妊娠期高血压和子痫前期对暴露组分层与对照组比较。结果 暴露组在分娩方式、早产、宫内缺氧、低出生体重儿、转新生儿科或转院、新生儿出生体重、身长、生后1 min和5 min Apgar评分方面与对照组相比,差异均存在统计学意义(P<0.05),且子痫前期导致的不良妊娠及新生儿结局更严重。结论 妊娠期高血压及子痫前期对孕妇及新生儿造成了不良影响,应当加强育龄妇女的保健,积极预防和治疗妊娠期高血压疾病,实现优生
孕期体质量指数与子痫前期发病机制的研究
Study on Body Mass Index and Pathogenesis of Preeclampsia during Pregnancy  [PDF]
李书明, 关红琼
Advances in Clinical Medicine (ACM) , 2023, DOI: 10.12677/ACM.2023.132213
Abstract: 目的：探讨孕期体质量指数(BMI)与子痫前期的相关性。方法：选择在2021.01.01~2022.10.31在海南医学院第二附属医院产科住院并分娩的符合纳入标准的50例子痫前期孕妇和50例重度子痫前期孕妇分别作为子痫前期组、重度子痫前期组，随机选择同期50例正常妊娠孕妇为对照组。比较每两组孕产妇BMI的差异性。结果：与正常组相比，子痫前期组P = 0.00047 (P < 0.05)，差异具有统计学意义；重度子痫前期组P = 2.4e？05 (P < 0.05)，差异具有统计学意义；三组之间进行多因素分析，P = 2.6e？05 (P < 0.05)，差异具有统计学意义。子痫前期与重度子痫前期之间P = 0.19 (P > 0.05)，具有组间差异。结论：子痫前期产妇BMI与正常孕妇有显著差异。BMI对于子痫前期的发生有一定的预测价值。
Objective: To investigate the correlation between prenatal body mass index (BMI) and preeclamp-sia. Methods: 50 cases of pregnant women with preeclampsia and 50 cases of pregnant women with severe preeclampsia who were hospitalized and gave birth in the Obstetrics Department of the Second Affiliated Hospital of Hainan Medical University from 2021.01.01 to 2022.10.31 were se-lected as the preeclampsia group and the severe preeclampsia group, respectively, and 50 normal pregnant women during the same period were randomly selected as the control group. The differ-ences in BMI between the two groups were compared. Results: Compared with normal group, preeclampsia group P = 0.00047 (P < 0.05), the difference was statistically significant. In severe preeclampsia group, P = 2.4e？05 (P < 0.05), the difference was statistically significant. Multivariate analysis was performed among the three groups, P = 2.6e？05 (P < 0.05), and the difference was sta-tistically significant. The difference between preeclampsia and severe preeclampsia was P = 0.19 (P > 0.05). Conclusion: The BMI of preeclampsia women is significantly different from that of normal women. BMI has a certain predictive value for preeclampsia.
双胎绒毛膜性与子痫前期相关性的研究
Study on the Relationship between Chorionic Villus and Preeclampsia in Twins  [PDF]
金雪頔, 王志梅
Advances in Clinical Medicine (ACM) , 2023, DOI: 10.12677/ACM.2023.132381
Abstract: 随着辅助生殖技术(ART, Assisted Reproductive Technology)的发展以及促排卵药物的应用，双胎妊娠显著增多。子痫前期是妊娠期特有的并发症之一。过去研究中，对于子痫前期危险因素及造成母婴结局多限于单胎妊娠，而不同绒毛膜性双胎妊娠的危险因素，母婴结局以及如何有效的预防子痫前期发病尚不明确。本文基于绒毛膜性不同的双胎妊娠并发子痫前期的危险因素，母婴结局及临床管理要点的国内外进展进行综述，以加强双胎妊娠合并子痫前期的临床管理。
With the development of assisted reproductive technology (ART, Assisted Reproductive Technology) and the application of ovulation-inducing drugs, twin pregnancy has increased significantly. Preeclampsia is one of the unique complications of pregnancy. In previous studies, the risk factors related to preeclampsia and maternal and infant outcomes are mostly limited to singleton preg-nancy, while the risk factors of different chorionic twin pregnancies, maternal and infant outcomes and how to effectively prevent the pathogenesis of preeclampsia are not clear. This article reviews the progress at home and abroad on the risk factors, maternal and infant outcome and clinical management of preeclampsia in different chorionic twin pregnancies, in order to strengthen the clinical management of twin pregnancy with preeclampsia.
妊娠期高血压疾病的发病机制、临床治疗 与护理对策研究进展
Research Progress on Pathogenesis, Clinical Treatment and Nursing Countermeasures of Hypertensive Disorders of Pregnancy  [PDF]
鲁佳, 庞宝华
Advances in Clinical Medicine (ACM) , 2026, DOI: 10.12677/acm.2026.1652041
Abstract: 妊娠期高血压疾病是妊娠期特有的、严重威胁母婴安全的并发症，也是导致孕产妇和围生儿死亡的重要原因之一。近年来，随着发病机制研究的深入、诊疗指南的更新、护理模式的创新，在风险预警、药物治疗、综合干预、全程管理等方面取得了许多进展。本文结合国内外最新研究和临床指南，对妊娠期高血压的发病机制、临床治疗、专科护理等方面的研究进展进行综述，旨在为临床实践中优化诊疗、护理方案、改善母婴结局提供循证参考。
Hypertensive disorders of pregnancy is a pregnancy-specific complication that seriously threatens the safety of mothers and infants, and it is also one of the important causes of maternal and perinatal deaths. In recent years, with the deepening of pathogenesis research, the update of diagnosis and treatment guidelines, and the innovation of nursing models, many advances have been made in risk warning, drug treatment, comprehensive intervention, and whole-process management. Based on the latest research and clinical guidelines at home and abroad, this article reviews the research progress in the pathogenesis, clinical treatment, and specialized nursing of gestational hypertension, aiming to provide evidence-based reference for optimizing diagnosis and treatment, nursing programs, and improving maternal and infant outcomes in clinical practice.
拉贝洛尔联合硝苯地平对妊娠期高血压疾病患者凝血及血管内皮功能的调控作用与疗效研究进展
Research Progress on the Regulatory Effects and Therapeutic Efficacy of Labetalol Combined with Nifedipine on Coagulation and Vascular Endothelial Function in Patients with Gestational Hypertension  [PDF]
程小青, 李妹燕
Asian Case Reports in Emergency Medicine (ACREM) , 2026, DOI: 10.12677/acrem.2026.141009
Abstract: 妊娠期高血压疾病是一种妊娠期特有的疾病，严重威胁孕妇和胎儿健康。拉贝洛尔与硝苯地平的联合治疗方案近年来在临床应用中优势明显。研究表明，联合用药能通过多途径协同联合降低血压，改善血管内皮功能，调节凝血纤溶系统，降低不良母婴结局发生率。现就拉贝洛尔与硝苯地平联合使用对妊娠期高血压疾病患者凝血功能及血管内皮功能的调控作用与临床疗效予以综述，为妊娠期高血压疾病的临床治疗提供新的思路。
Hypertensive disorders in pregnancy are specific diseases during pregnancy that seriously threaten the health of pregnant women and their fetuses. The combined treatment of labetalol and nifedipine has shown significant advantages in clinical application in recent years. Studies have shown that the combined use of these drugs can lower blood pressure through multiple pathways, improve vascular endothelial function, regulate the coagulation and fibrinolysis system, and reduce the incidence of adverse maternal and neonatal outcomes. This article reviews the regulatory effects of the combined use of labetalol and nifedipine on the coagulation function and vascular endothelial function of patients with hypertensive disorders in pregnancy and their clinical efficacy, providing new ideas for the clinical treatment of hypertensive disorders in pregnancy.
孕产妇妊娠期高血压疾病的发病、转归与季节气候的相关性分析
任雁林,李曼,曹慧兰,陈丽华,黄永刚,杨春芳,王丽
第三军医大学学报 , 2014,
Abstract:
肠道菌群代谢产物短链脂肪酸与子痫前期的相关性研究进展
Research Progress on the Correlation between Short Chain Fatty Acids, Metabolites of Intestinal Microbiota, and Pre-Eclampsia  [PDF]
徐子欣, 王翠秀
Advances in Clinical Medicine (ACM) , 2024, DOI: 10.12677/acm.2024.14123169
Abstract: 子痫前期是发生于妊娠期特有的高血压，极大地危害母婴健康。目前病因及发病机制尚未完全阐明。已有的研究表明子痫前期可能与全身炎症反应过度激活、氧化应激、免疫紊乱等有关。肠道菌群的失衡可能在炎症激活、免疫失衡、氧化应激等方面发挥作用从而参与子痫前期的发生发展。短链脂肪酸作为肠道菌群的重要代谢产物，在血压、代谢及免疫功能调节和抑制炎症反应等方面具有积极的作用。有研究表明短链脂肪酸的成分含量构成在子痫前期状态下也发生变化，这为进一步探究子痫前期的发病机制及防治提供了新思路。
Pre-eclampsia is a unique form of hypertension that occurs during pregnancy and greatly endangers the health of the mother and child. The etiology and pathogenesis have not yet been fully elucidated. Studies have shown that preeclampsia may be associated with over-activation of systemic inflammatory response, oxidative stress, and immune disorders. Imbalance of intestinal flora may play a role in inflammatory activation, immune imbalance, oxidative stress, etc. and thus participate in the development of preeclampsia. As important metabolites of intestinal flora, short-chain fatty acids have positive effects on blood pressure, metabolism and immune function regulation, and inhibition of inflammatory response. Some studies have shown that the composition of short-chain fatty acids also changes in preeclampsia, which provides new ideas for further investigation of the pathogenesis and prevention of pre-eclampsia.
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