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孕期体质量指数与子痫前期发病机制的研究
Study on Body Mass Index and Pathogenesis of Preeclampsia during Pregnancy

DOI: 10.12677/ACM.2023.132213, PP. 1546-1551

Keywords: 体重指数,子痫前期,妊娠期高血压疾病
Body Mass Index
, Pre-Eclampsia, Pregnancy Hypertension

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Abstract:

目的:探讨孕期体质量指数(BMI)与子痫前期的相关性。方法:选择在2021.01.01~2022.10.31在海南医学院第二附属医院产科住院并分娩的符合纳入标准的50例子痫前期孕妇和50例重度子痫前期孕妇分别作为子痫前期组、重度子痫前期组,随机选择同期50例正常妊娠孕妇为对照组。比较每两组孕产妇BMI的差异性。结果:与正常组相比,子痫前期组P = 0.00047 (P < 0.05),差异具有统计学意义;重度子痫前期组P = 2.4e?05 (P < 0.05),差异具有统计学意义;三组之间进行多因素分析,P = 2.6e?05 (P < 0.05),差异具有统计学意义。子痫前期与重度子痫前期之间P = 0.19 (P > 0.05),具有组间差异。结论:子痫前期产妇BMI与正常孕妇有显著差异。BMI对于子痫前期的发生有一定的预测价值。
Objective: To investigate the correlation between prenatal body mass index (BMI) and preeclamp-sia. Methods: 50 cases of pregnant women with preeclampsia and 50 cases of pregnant women with severe preeclampsia who were hospitalized and gave birth in the Obstetrics Department of the Second Affiliated Hospital of Hainan Medical University from 2021.01.01 to 2022.10.31 were se-lected as the preeclampsia group and the severe preeclampsia group, respectively, and 50 normal pregnant women during the same period were randomly selected as the control group. The differ-ences in BMI between the two groups were compared. Results: Compared with normal group, preeclampsia group P = 0.00047 (P < 0.05), the difference was statistically significant. In severe preeclampsia group, P = 2.4e?05 (P < 0.05), the difference was statistically significant. Multivariate analysis was performed among the three groups, P = 2.6e?05 (P < 0.05), and the difference was sta-tistically significant. The difference between preeclampsia and severe preeclampsia was P = 0.19 (P > 0.05). Conclusion: The BMI of preeclampsia women is significantly different from that of normal women. BMI has a certain predictive value for preeclampsia.

References

[1]  吴琳琳, 周欣, 牛建民. 《妊娠期高血压疾病: 国际妊娠期高血压研究学会分类, 诊断和管理指南(2018)》解读[J]. 中国实用妇科与产科杂志, 2018, 34(7): 758-763.
[2]  Lip, S.V., Boekschoten, M.V., Hooiveld, G.J., et al. (2020) Early-Onset Preeclampsia, Plasma microRNAs, and Endothelial Cell Function. American Journal of Obstetrics and Gy-necology, 222, 497.e1-497.e12.
https://doi.org/10.1016/j.ajog.2019.11.1286
[3]  Li, H., Ouyang, Y., Sadovsky, E., et al. (2020) Unique mi-croRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia. Hypertension, 75, 762-771.
https://doi.org/10.1161/HYPERTENSIONAHA.119.14081
[4]  Qu, H. and Khalil, R.A. (2020) Vascular Mecha-nisms and Molecular Targets in Hypertensive Pregnancy and Preeclampsia. The American Journal of Physiology-Heart and Circulatory Physiology, 319, H661-H681.
https://doi.org/10.1152/ajpheart.00202.2020
[5]  李精华, 杨柳, 陈庆, 等. 妊娠前体质指数及妊娠期体重增加对妊娠并发症和妊娠结局影响的前瞻性队列研究[J]. 中华妇产科杂志, 2019, 54(3): 184.
[6]  孟国花, 周玲. 孕前体质指数及孕期体重的增加对妊娠结局的影响[J]. 安徽医药, 2012, 16(6): 778-780.
[7]  杨孜, 张为远. 妊娠期高血压疾病的早期识别(一) [J]. 中华妇产科杂志, 2019, 54(7): 501-502.
[8]  袁峰, 韩曦, 王亚琴, 等. 间苯三酚联合拉贝洛尔治疗妊娠高血压疾病的疗效研究[J]. 现代生物医学进展, 2019, 19(21): 4060-4063, 4156.
[9]  孙芳璨. 妊娠期高血压疾病不良结局预测模型的研究进展[J]. 实用妇产科杂志, 2019, 35(9): 677-681.
[10]  郭冰杰, 杨彩梅. 血浆中D-dimer在正常妊娠及妊娠高血压疾病孕妇中的表达差异[J]. 中国实验诊断学, 2020, 24(1): 48-51.
[11]  Chen, A., Zhao, H., Wang, J., et al. (2020) Haplotype Analysis of Candidate Genes Involved in Inflamma-tion and Oxidative Stress and the Susceptibility to Preeclampsia. Immunologic Research, 2020, Article ID: 4683798.
https://doi.org/10.1155/2020/4683798
[12]  Park, S., Shin, J., Bae, J., et al. (2020) SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts. Cells, 9, 728.
https://doi.org/10.3390/cells9030728
[13]  Liu, Z., Zhao, X., Shan, H.Y., et al. (2019) microRNA-520c-3p Sup-presses NLRP3 Inflammasome Activation and Inflammatory Cascade in Preeclampsia by Downregulating NLRP3. In-flammation Research, 68, 643-654.
https://doi.org/10.1007/s00011-019-01246-8
[14]  Banerjee, S., Huang, Z., Wang, Z., et al. (2021) Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication? Frontiers in Cellular and Infection Microbiology, 11, Article ID: 694298.
https://doi.org/10.3389/fcimb.2021.694298
[15]  Cheng, S.B., Nakashima, A., Huber, W.J., et al. (2019) Pyropto-sis Is a Critical Inflammatory Pathway in the Placenta from Early Onset Preeclampsia and in Human Trophoblasts Ex-posed to Hypoxia and Endoplasmic Reticulum Stressors. Cell Death & Disease, 10, 927.
https://doi.org/10.1038/s41419-019-2162-4
[16]  Tersigni, C., Vatish, M., D’Ippolito, S., et al. (2020) Abnormal Uterine Inflammation in Obstetric Syndromes: Molecular Insights into the Role of Chemokine Decoy Receptor D6 and Inflammasome NLRP3. Molecular Human Reproduction, 26, 111-121.
https://doi.org/10.1093/molehr/gaz067
[17]  Laresgoiti-Servitje, E. (2013) A Leading Role for the Immune System in the Pathophysiology of Preeclampsia. Journal of Leukocyte Biology, 94, 247-257.
https://doi.org/10.1189/jlb.1112603
[18]  Bellamy, L., Casas, J.P., Hingorani, A.D., et al. (2007) Pre-Eclampsia and Risk of Cardiovascular Disease and Cancer in Later Life: Systematic Review and Meta-Analysis. BMJ, 335, 974.
https://doi.org/10.1136/bmj.39335.385301.BE
[19]  Harmon, A.C., Cornelius, D.C., Amaral, L.M., et al. (2016) The Role of Inflammation in the Pathology of Preeclampsia. Clinical Science (London), 130, 409-419.
https://doi.org/10.1042/CS20150702
[20]  Seki, H. (2014) The Role of the Renin-Angiotensin System in the Path-ogenesis of Preeclampsia—New Insights into the Renin-Angiotensin System in Preeclampsia. Medical Hypotheses, 82, 362-367.
https://doi.org/10.1016/j.mehy.2013.12.024
[21]  Valencia-Ortega, J., Zarate, A., Saucedo, R., et al. (2019) Placen-tal Proinflammatory State and Maternal Endothelial Dysfunction in Preeclampsia. Gynecologic and Obstetric Investiga-tion, 84, 12-19.
https://doi.org/10.1159/000491087
[22]  Quan, X.Z., Ye, J.H., Yang, X.Z., et al. (2021) HOXA9-Induced Chemerin Signals through CMKLR1/AMPK/TXNIP/ NLRP3 Pathway to Induce Pyroptosis of Trophoblasts and Aggravate Preeclampsia. Experimental Cell Research, 408, Article ID: 112802.
https://doi.org/10.1016/j.yexcr.2021.112802
[23]  Kerbel, R.S. (2000) Tumor Angiogenesis: Past, Present and the Near Future. Carcinogenesis, 21, 505-515.
https://doi.org/10.1093/carcin/21.3.505
[24]  Fagiani, E. and Christofori, G. (2013) Angiopoietins in Angiogenesis. Cancer Letters, 328, 18-26.
https://doi.org/10.1016/j.canlet.2012.08.018
[25]  谭艺. 控制体重对预防发生妊娠期高血压的效果观察[J]. 国际护理学杂志, 2018, 37(12): 1640-1642.
[26]  金嫔嫔, 陈玲萍. 子痫前期发病的高危因素分析[J]. 中国妇幼保健, 2019, 34(24): 5625-5627.
[27]  郭晓蒙, 张烨, 王娟, 等. BMI联合血脂对妊娠期高血压及子痫前期的预测价值[J]. 中国妇产科临床杂志, 2019, 20(3): 199-201.

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