%0 Journal Article
%T Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols
%A Rubina Bibi
%A Amina Sadiq
%A Ehsan Ullah Mughal
%J Open Journal of Medicinal Chemistry
%P 15-25
%@ 2164-313X
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojmc.2022.122002
%X A series of 4-thioflavonols compounds were synthesized by treating
flavonols with lawsons reagent with variable substituent groups at A, B, and AB
rings. <span>All the synthesized compounds were
checked for antibacterial and antifungal activity. We report that many
compounds were found active against <i>Escherichia</i> <i>coli</i>, <i>Pseudomonas</i> <i>aeruginosa</i>, <i>Staphylococcus</i> <i>aureus</i>, </span><i><span>Methicillin-resistant</span></i><span> <i>Staphylococcus</i> <i>aureus</i>, bacterial strains and, <i>C. albicans</i>,</span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><i><span style=\"font-family:;\" \"=\"\">C. parap</span></i></span></span><span><span><i><span style=\"font-family:;\" \"=\"\">silosisstrains</span></i></span></span><span><span><span style=\"font-family:;\" \"=\"\"> and<i> C.</i></span></span></span><span><span><i><span style=\"font-family:;\" \"=\"\"> </span></i></span></span><span><span><i><span style=\"font-family:;\" \"=\"\">krusei</span></i></span></span><span><span><span style=\"font-family:;\" \"=\"\"> fungal strains<span>. Most of the synthesized 4-thioflavonols </span></span></span></span><span><span><span style=\"font-family:;\" \"=\"\">compounds</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> were found</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> to show enhanced antimicrobial activity than
respective flavonol compounds.</span></span></span>
%K Flavonols
%K 4-Thioflavonols
%K Flavonoids
%K Lawsons Reagent
%K Antibacterial Activity
%K Antifungal Activity
%K One Pot Synthesis
%K Sulfur Compounds
%K SAR Studies
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=120104