Sumoylation of Notch1 represses its target gene expression during cell stress

Notch as a sumoylation target protein. a The sequence around the putative sumoylation site K1774/K1780/K1781/K1782 is located in the intracellular domain of Notch. b Sequence alignment of the Notch1 region surrounding the putative sumoylation site K1780 using the Clustal Omega web-based tool. The putative sumoylation site is highlighted in gra