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Mar 23, 2026Open Access
Background: Sturge Weber syndrome (SWS) is a rare, sporadic neurocutaneous disorder caused by somatic mutations in the GNAQ gene, characterized by vascular malformations involving the skin, leptomeninges, and eyes. Although facial port-wine stains, seizures, and ocular abnormalities are the hallmark features, oral manifestations are less frequently reported and may represent an early clinical sign of the disease. Case Presentation: We report the case of a 12-year-old girl who presented with prog...
Jan 21, 2026Open Access
Background: Collagenous Fibroma (CF) of the nail, particularly the finger, is exceedingly uncommon. Although uncommon, they should be included in the differential diagnosis of nail abnormalities. Early diagnosis and complete surgical excision lead to an excellent prognosis with a minimal risk of recurrence. Objective: To raise awareness of the rarity of this condition to improve its early diagnosis and management. Case Report: A 72-year-old woma...
Nov 27, 2025Open Access
Chronic inflammatory cutaneous diseases, such as atopic dermatitis (AD) and psoriasis, are complex disorders influenced by immune dysregulation, various genetic factors, and more recently identified alterations within the skin microbiome. Among the skin’s commensal organisms, Malassezia species play a significant role in modulating both skin inflammation and barrier function. These fungi are normally harmless; becoming pathogenic under specific immune or environmental conditions is one ...
Aug 07, 2025Open Access
We present a rare and potential life-threathning case of a 58-year-old man who came in with pruritic skin lesions that were intensively painful, small erythematous pustules that were sterile and scaly, located on both upper and lower extremities and lower back that gradually increased and spread to the limbs, trunk, face and scalp, alongside he was with nail thickening, yellow and white nail discoloration and onycholysis. These symptoms had persisted for over 20 years with multiple recurrences a...
Apr 11, 2025Open Access
Background and objectives: Lupus nephritis is one of the most common complications of Systemic Lupus Erythematosus, due to the accumulation of immunocomplexes of antigens and antibodies at the renal level. In the laboratory, serum anti-C1q antibody levels have become an important tool for monitoring and management of this disease. This study evidences the levels of anti-C1q as a marker of renal involvement in patients with SLE. Patients and methods: The study wa...
Feb 25, 2025Open Access
Introduction: This abstract reports a case of calcinosis cutis, a rare complication of acne vulgaris, in a 30-year-old woman. Acne vulgaris is a common skin disease characterized by various lesions, including comedones, papules, pustules, and nodules. While hyperpigmentation and scarring are common complications, calcinosis cutis, involving calcium salt deposits in the skin and subcutaneous tissue, is rare. Case Presentation: A 30-year-old woman with a long hist...
Mar 27, 2024Open Access
Mohs technique is a precise method for removing skin tumors that, during excision, preserves healthy tissue. Common skin tumors treated with this technique are squamous and basal cell carcinoma. The American College of Mohs Surgery has established guidelines for the use of the technique. Tumor localization, patient characteristics, and tumor features should be considered when assessing whether this technique is the right choice. It’s useful in regions such as eyelids, lips and genitals. There ar...
Aug 29, 2023Open Access
Background: The use of flaps is an important procedure in Plastic Surgery for the coverage of traumatic wounds, oncological resections, and burn reconstruction, among others. Drugs such as vasodilators (isoxsuprine, nitroglycerin), could increase tissue perfusion to optimize flap viability. In this study, the local and systemic effects of the use of topical nitroglycerin to increase the survival area of skin flaps were analyzed in a murine model. Methods: In our pilot study, we included twenty m...
Jul 21, 2023Open Access
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Nov 26, 2019Open Access
Traditional Chinese Medicine (TCM), especially the extractive, has been ex-tensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain to be investigated. In this study, we evaluated the anti-melanoma activity of the extractive Crocin (CRO) from the Chinese herbals saffron. After corresponding time of oral administration, CRO can’t obviously decrease the proliferation o ...
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