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Mar 27, 2024Open    Access

Mohs Micrographic Surgery Technique

Marko Vla?i?,Sandra Jel?i?,Ivan Be?enji,Ivana Smiljani?
Mohs technique is a precise method for removing skin tumors that, during excision, preserves healthy tissue. Common skin tumors treated with this technique are squamous and basal cell carcinoma. The American College of Mohs Surgery has established guidelines for the use of the technique. Tumor localization, patient characteristics, and tumor features should be considered when assessing whether this technique is the right choice. It’s useful in regions such as eyelids, lips and genitals. There ar...
Open Access Library J.   Vol.11, 2024
Doi:10.4236/oalib.1111247


Aug 29, 2023Open    Access

Effect of Topical Nitroglycerin on the Survival of Random Pattern Vascular Skin Flaps in a Rat Model: Pilot Study

Luis O. Flores-Salazar, Sergio E. Vázquez-Lara, Benjamín Jesús Moya-Leal, Gabriel A. Mecott-Rivera, Mauricio M. García-Pérez, Everardo Valdés-Flores, Yanko Castro-Govea
Background: The use of flaps is an important procedure in Plastic Surgery for the coverage of traumatic wounds, oncological resections, and burn reconstruction, among others. Drugs such as vasodilators (isoxsuprine, nitroglycerin), could increase tissue perfusion to optimize flap viability. In this study, the local and systemic effects of the use of topical nitroglycerin to increase the survival area of skin flaps were analyzed in a murine model. Methods: In our pilot study, we included twenty m...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110445


Jul 21, 2023Open    Access

Atopic Dermatitis Related to RNF31 Genetic Variant

César Daniel Alonso-Bello, Sonia del Carmen Chávez-Ocana, Carol Vivian Moncayo-Coello, María Isabel Rojo-Gutierrez
Atopic dermatitis is a chronic and inflammatory skin disease and the most severe forms could strongly impact the patient’s quality of life. Skin barrier dysfunction is considered the first step in the atopic march. RNF31 deficiency significantly changes the skin structure and increases its thickness. The keratinocytes show decreased expression of K10 and loricrin. In this way, RNF31 deficiency alters the proper functioning of the skin by altering the homeostasis of keratinocytes. W...
Open Access Library J.   Vol.10, 2023
Doi:10.4236/oalib.1110339


Nov 26, 2019Open    Access

Crocin Inhibits the Melanoma Invasion and Metastasis by Regulating the Polarization Phenotype of Macrophage

Zhouli Shen, Yi Lu, Jie Shen, Yating Zahng, Sichen Shen
Traditional Chinese Medicine (TCM), especially the extractive, has been ex-tensively used in clinical practices and proven to be effective against cancer. However, the underlying mechanisms remain to be investigated. In this study, we evaluated the anti-melanoma activity of the extractive Crocin (CRO) from the Chinese herbals saffron. After corresponding time of oral administration, CRO can’t obviously decrease the proliferation o
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Open Access Library J.   Vol.6, 2019
Doi:10.4236/oalib.1105871


Apr 19, 2018Open    Access

Wrinkle Severity Grading Scale: A Southeast Asia Study

Brian Tian
Objective wrinkle grading scales have been described for Caucasians and Japanese, but none for South-east Asians. Southeast Asians tend to be darker in skin complexion (usually skin types IV and above). A wrinkle scale using fairer Caucasian and Japanese skin, may not be easily applicable for the darker Southeast Asian skin. Therefore, in this paper, we describe and validate a wrinkle grading
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Open Access Library J.   Vol.5, 2018
Doi:10.4236/oalib.1103757


Apr 19, 2018Open    Access

Building Artificial Intelligence for Dermatological Practice

Brian Tian
Purpose: Wrinkles are the most visually obvious features of aging and are the prime target of a vast number of products (both medical and cosmetic). It is important for clinicians to be able to grade wrinkles objectively. Although wrinkles are easily recognisable for humans, it remains a very challenging task for computer vision systems to detect them automatically. In our center, we developed a wrinkle detection algorithm based o
...
Open Access Library J.   Vol.5, 2018
Doi:10.4236/oalib.1104541


Jul 28, 2017Open    Access

The Role of Polypodium leucotomos Extract in the Treatment of Porphyria Cutanea Tarda

Michael Hatch, Lisa Mask-Bull, Michelle B. Tarbox
The dermatologic manifestations of porphyrias result from localized cutaneous formation of reactive oxygen species. The significance of these inflammatory mediators may extend beyond the skin, as increased oxidative stress may play a role in the systemic manifestations of porphyrias. Polypodium leucotomos is a tropical fern that has demonstrated antioxidant, ant
...
Open Access Library J.   Vol.4, 2017
Doi:10.4236/oalib.1102858


Jul 27, 2016Open    Access

The Comparison of the Levels of Leukotriene B4, TGF-β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast

Yuli Kurniawati, Oki Suwarsa, Achadiyani Agung, Sudigdo Adi
Keloid pathogenesis occurs due to the longer duration of inflammation and the increase in the production of several factors such as TGF-β1 that causes the increase of fibroblast proliferation and collagen synthesis. The role of B4 Leukotriene (LTB4) in keloid pathogenesis particularly in the inflammation phase and tissue proliferation has not been clearly elucid
...
Open Access Library J.   Vol.3, 2016
Doi:10.4236/oalib.1102801


Oct 19, 2015Open    Access

The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study

Gordon H. Sasaki
Background: Human growth factors serve as secretomes that regulate skin cell proliferation/differentiation and production of extracellular elements of the matrix and treat photo-aging. Microneedling of skin can also improve aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic benefits. Objectives: This open, randomized split-face and single-center controlled study evaluated the safety and efficacy of the application of a cosmeceutical form...
Open Access Library J.   Vol.2, 2015
Doi:10.4236/oalib.1101867


Apr 01, 2015Open    Access

Nosocomial Infections in a Morocco Burn Unit

Amine Rafik, Hakim Chabbak, Kawtare Jouhri, Mounia Diouri, Naima Bahechar, Abdes-samad Chlihi
Introduction: The bacterial nosocomial infection remains a common cause of death in patients who have sustained a severe burn injury. Material and Methods: We conducted a prospective study of 45 patients hospitalized in the ICU burns Hospital IBN-ROCHD of Casablanca over a period of six months, from 1 January 2014 to 30 June 2014. The criteria for nosocomial infection were those of the Center for Disease Control in Atlanta in 1988. Result: Incidence rates were calculated. The bacterial ecology o...
Open Access Library J.   Vol.2, 2015
Doi:10.4236/oalib.1101394


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